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Size measurements of tumor manifestations on follow-up CT examinations are crucial for evaluating treatment outcomes in cancer patients. Efficient lesion segmentation can speed up these radiological workflows. While numerous benchmarks and…

Image and Video Processing · Electrical Eng. & Systems 2024-06-24 M. J. J. de Grauw , E. Th. Scholten , E. J. Smit , M. J. C. M. Rutten , M. Prokop , B. van Ginneken , A. Hering

In this study, we present ULS+, an enhanced version of the Universal Lesion Segmentation (ULS) model. The original ULS model segments lesions across the whole body in CT scans given volumes of interest (VOIs) centered around a click-point.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-07 Rianne Weber , Niels Rocholl , Max de Grauw , Mathias Prokop , Ewoud Smit , Alessa Hering

Tracking tumor lesions across serial CT scans is essential for oncological response assessment. Existing automated methods face a fundamental trade-off: end-to-end trackers achieve high automation but offer no opportunity to correct silent…

Computer Vision and Pattern Recognition · Computer Science 2026-05-25 Yannick Kirchhoff , Maximilian Rokuss , Daniel Philipp Mertens , David Füller , Benjamin Hamm , Andreas Schreyer , Oliver Ritter , Klaus Maier-Hein

Accurate segmentation of Multiple Sclerosis (MS) lesions in longitudinal MRI scans is crucial for monitoring disease progression and treatment efficacy. Although changes across time are taken into account when assessing images in clinical…

Accurate segmentation of lesions in longitudinal whole-body CT is essential for monitoring disease progression and treatment response. While automated methods benefit from incorporating longitudinal information, they remain limited in their…

Image and Video Processing · Electrical Eng. & Systems 2025-09-03 Yannick Kirchhoff , Maximilian Rokuss , Fabian Isensee , Klaus H. Maier-Hein

In recent years, machine learning algorithms have achieved much success in segmenting lesions across various tissues. There is, however, not one satisfying model that works well on all tissue types universally. In response to this need, we…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Kaiwen Shi , Yifei Li , Binh Ho , Jovian Wang , Kobe Guo

Accurate segmentation of small lesions in Breast Dynamic Contrast-Enhanced MRI (DCE-MRI) is critical for early cancer detection, especially in high-risk patients. While recent deep learning methods have advanced lesion segmentation, they…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Mohammed Kamran , Maria Bernathova , Raoul Varga , Christian F. Singer , Zsuzsanna Bago-Horvath , Thomas Helbich , Georg Langs , Philipp Seeböck

Cancer evolves continuously over time through a complex interplay of genetic, epigenetic, microenvironmental, and phenotypic changes. This dynamic behavior drives uncontrolled cell growth, metastasis, immune evasion, and therapy resistance,…

Quantitative Methods · Quantitative Biology 2025-07-08 Luoting Zhuang , Stephen H. Park , Steven J. Skates , Ashley E. Prosper , Denise R. Aberle , William Hsu

Uncertainty quantification (UQ) has become critical for evaluating the reliability of artificial intelligence systems, especially in medical image segmentation. This study addresses the interpretability of instance-wise uncertainty values…

A major challenge in stroke research and stroke recovery predictions is the determination of a stroke lesion's extent and its impact on relevant brain systems. Manual segmentation of stroke lesions from 3D magnetic resonance (MR) imaging…

Image and Video Processing · Electrical Eng. & Systems 2023-06-21 Sovesh Mohapatra , Advait Gosai , Anant Shinde , Aleksei Rutkovskii , Sirisha Nouduri , Gottfried Schlaug

The field of lung nodule detection and cancer prediction has been rapidly developing with the support of large public data archives. Previous studies have largely focused on cross-sectional (single) CT data. Herein, we consider longitudinal…

The detection of new multiple sclerosis (MS) lesions is an important marker of the evolution of the disease. The applicability of learning-based methods could automate this task efficiently. However, the lack of annotated longitudinal data…

Image and Video Processing · Electrical Eng. & Systems 2022-06-17 Reda Abdellah Kamraoui , Boris Mansencal , José V Manjon , Pierrick Coupé

The development of compact and energy-efficient wearable sensors has led to an increase in the availability of biosignals. To analyze these continuously recorded, and often multidimensional, time series at scale, being able to conduct…

Machine Learning · Computer Science 2022-08-02 Knut J. Strømmen , Jim Tørresen , Ulysse Côté-Allard

Segmentation of Multiple Sclerosis (MS) lesions in longitudinal brain MR scans is performed for monitoring the progression of MS lesions. We hypothesize that the spatio-temporal cues in longitudinal data can aid the segmentation algorithm.…

Image and Video Processing · Electrical Eng. & Systems 2020-09-29 Stefan Denner , Ashkan Khakzar , Moiz Sajid , Mahdi Saleh , Ziga Spiclin , Seong Tae Kim , Nassir Navab

Multiple sclerosis (MS) expresses substantial clinical and radiological heterogeneity, which poses significant challenges for automatic lesion segmentation. The current deep learning-based SOTA is highly susceptible to changes in both…

This paper explores uncertainty quantification (UQ) as an indicator of the trustworthiness of automated deep-learning (DL) tools in the context of white matter lesion (WML) segmentation from magnetic resonance imaging (MRI) scans of…

Whole-body PET/CT is a cornerstone of oncological imaging, yet accurate lesion segmentation remains challenging due to tracer heterogeneity, physiological uptake, and multi-center variability. While fully automated methods have advanced…

Computer Vision and Pattern Recognition · Computer Science 2025-09-01 Maximilian Rokuss , Yannick Kirchhoff , Fabian Isensee , Klaus H. Maier-Hein

Deep learning models (DLMs) frequently achieve accurate segmentation and classification of tumors from medical images. However, DLMs lacking feedback on their image segmentation mechanisms, such as Dice coefficients and confidence in their…

Image and Video Processing · Electrical Eng. & Systems 2024-12-31 Elhoucine Elfatimi , Pratik Shah

Evaluating lesion progression and treatment response via longitudinal lesion tracking plays a critical role in clinical practice. Automated approaches for this task are motivated by prohibitive labor costs and time consumption when lesion…

Computer Vision and Pattern Recognition · Computer Science 2022-12-13 Wen Tang , Han Kang , Haoyue Zhang , Pengxin Yu , Corey W. Arnold , Rongguo Zhang

Accurately segmenting a variety of clinically significant lesions from whole body computed tomography (CT) scans is a critical task on precision oncology imaging, denoted as universal lesion segmentation (ULS). Manual annotation is the…

Image and Video Processing · Electrical Eng. & Systems 2021-05-05 Youbao Tang , Jinzheng Cai , Ke Yan , Lingyun Huang , Guotong Xie , Jing Xiao , Jingjing Lu , Gigin Lin , Le Lu
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