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Sequence comparison and alignment has had an enormous impact on our understanding of evolution, biology, and disease. Comparison and alignment of biological networks will likely have a similar impact. Existing network alignments use…

Molecular Networks · Quantitative Biology 2009-10-08 Oleksii Kuchaiev , Tijana Milenkovic , Vesna Memisevic , Wayne Hayes , Natasa Przulj

Graph convolutional networks are a popular class of deep neural network algorithms which have shown success in a number of relational learning tasks. Despite their success, graph convolutional networks exhibit a number of peculiar features,…

Machine Learning · Computer Science 2022-08-22 Thomas Gebhart

Deciding whether there is a single tree -a supertree- that summarizes the evolutionary information in a collection of unrooted trees is a fundamental problem in phylogenetics. We consider two versions of this question: agreement and…

Discrete Mathematics · Computer Science 2013-08-02 Sudheer Vakati , David Fernández-Baca

We provide a characterization of two types of directed homology for fully-connected, feedforward neural network architectures. These exact characterizations of the directed homology structure of a neural network architecture are the first…

Algebraic Topology · Mathematics 2020-03-03 Samir Chowdhury , Thomas Gebhart , Steve Huntsman , Matvey Yutin

Phylogenetic networks are often constructed by merging multiple conflicting phylogenetic signals into a directed acyclic graph. It is interesting to explore whether a network constructed in this way induces biologically-relevant…

Populations and Evolution · Quantitative Biology 2017-07-13 Steven Kelk , Fabio Pardi , Celine Scornavacca , Leo van Iersel

Designing algorithms that generate networks with a given degree sequence while varying both subgraph composition and distribution of subgraphs around nodes is an important but challenging research problem. Current algorithms lack control of…

Physics and Society · Physics 2015-12-07 Martin Ritchie , Luc Berthouze , Istvan Z Kiss

Maximum parsimony is one of the most frequently-discussed tree reconstruction methods in phylogenetic estimation. However, in recent years it has become more and more apparent that phylogenetic trees are often not sufficient to describe…

Populations and Evolution · Quantitative Biology 2016-10-25 Christopher Bryant , Mareike Fischer , Simone Linz , Charles Semple

Tree Containment is a fundamental problem in phylogenetics useful for verifying a proposed phylogenetic network, representing the evolutionary history of certain species. Tree Containment asks whether the given phylogenetic tree (for…

Populations and Evolution · Quantitative Biology 2024-06-14 Arkadiy Dushatskiy , Esther Julien , Leen Stougie , Leo van Iersel

Given any complex directed network, a set of acyclic subgraphs - the hierarchical backbone of the network - can be extracted that will provide valuable information about its hierarchical structure. The current paper presents how the…

Statistical Mechanics · Physics 2007-05-23 Luciano da Fontoura Costa

In 1989 Erd\H{o}s and Sz\'ekely showed that there is a bijection between (i) the set of rooted trees with $n+1$ vertices whose leaves are bijectively labeled with the elements of $[\ell]=\{1,2,\dots,\ell\}$ for some $\ell \leq n$, and (ii)…

Discrete Mathematics · Computer Science 2025-10-29 Vincent Moulton , Andreas Spillner

We study random graph models for directed acyclic graphs, an important class of networks that includes citation networks, food webs, and feed-forward neural networks among others. We propose two specific models, roughly analogous to the…

Physics and Society · Physics 2009-10-16 Brian Karrer , M. E. J. Newman

The concept of multilayer networks has become recently integrated into complex systems modeling since it encapsulates a very general concept of complex relationships. Biological pathways are an example of complex real-world networks, where…

Human-Computer Interaction · Computer Science 2021-10-12 Hsiang-Yun Wu , Martin Nöllenburg , Ivan Viola

The mathematical analysis of random phylogenetic networks via analytic and algorithmic methods has received increasing attention in the past years. In the present work we introduce branching process methods to their study. This approach…

Probability · Mathematics 2021-02-23 Benedikt Stufler

Ultametrics are an important class of distances used in applications such as phylogenetics, clustering and classification theory. Ultrametrics are essentially distances that can be represented by an edge-weighted rooted tree so that all of…

Combinatorics · Mathematics 2026-02-13 Katharina T. Huber , Vincent Moulton , Guillaume E. Scholz

In this work, we answer an open problem in the study of phylogenetic networks. Phylogenetic trees are rooted binary trees in which all edges are directed away from the root, whereas phylogenetic networks are rooted acyclic digraphs. For the…

Populations and Evolution · Quantitative Biology 2015-11-12 Andreas D. M. Gunawan , Bhaskar DasGupta , Louxin Zhang

This paper introduces a generalization of Convolutional Neural Networks (CNNs) to graphs with irregular linkage structures, especially heterogeneous graphs with typed nodes and schemas. We propose a novel spatial convolution operation to…

Machine Learning · Computer Science 2019-07-23 Aravind Sankar , Xinyang Zhang , Kevin Chen-Chuan Chang

In this short note we provide a proof of boundedness of solutions for a network system composed of heterogeneous nonlinear autonomous systems interconnected over a directed graph. The sole assumptions imposed are that the systems are…

Optimization and Control · Mathematics 2023-07-28 Anes Lazri , Elena Panteley , Antonio Loria

Exchangeable random graphs serve as an important probabilistic framework for the statistical analysis of network data. In this work we develop an alternative parameterization for a large class of exchangeable random graphs, where the nodes…

Statistics Theory · Mathematics 2020-05-01 Jing Lei

Chain graphs combine directed and undirected graphs and their underlying mathematics combines properties of the two. This paper gives a simplified definition of chain graphs based on a hierarchical combination of Bayesian (directed) and…

Artificial Intelligence · Computer Science 2013-02-21 Wray L. Buntine

A fundamental problem in the study of phylogenetic networks is to determine whether or not a given phylogenetic network contains a given phylogenetic tree. We develop a quadratic-time algorithm for this problem for binary nearly-stable…

Data Structures and Algorithms · Computer Science 2022-08-29 Philippe Gambette , Andreas D. M. Gunawan , Anthony Labarre , Stéphane Vialette , Louxin Zhang
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