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This work considers the problem of personalized dose guidance using Bayesian optimization that learns the optimum drug dose tailored to each individual, thus improving therapeutic outcomes. Safe learning using interior point method ensures…

Optimization and Control · Mathematics 2022-11-01 Dinesh Krishnamoorthy , Francis J. Doyle

Health management has become a primary problem as new kinds of diseases and complex symptoms are introduced to a rapidly growing modern society. Building a better and smarter healthcare infrastructure is one of the ultimate goals of a smart…

Machine Learning · Computer Science 2025-03-24 Chu Myaet Thwal , Kyi Thar , Ye Lin Tun , Choong Seon Hong

In this study, we present a novel clinical decision support system and discuss its interpretability-related properties. It combines a decision set of rules with a machine learning scheme to offer global and local interpretability. More…

Methodology · Statistics 2021-07-16 Francisco Valente , Simão Paredes , Jorge Henriques

Curriculum learning--ordering training examples in a sequence to aid machine learning--takes inspiration from human learning, but has not gained widespread acceptance. Static strategies for scoring item difficulty rely on indirect proxy…

Machine Learning · Computer Science 2026-03-17 Zhenwei Tang , Amogh Inamdar , Ashton Anderson , Richard Zemel

Personalized search plays a crucial role in improving user search experience owing to its ability to build user profiles based on historical behaviors. Previous studies have made great progress in extracting personal signals from the query…

Information Retrieval · Computer Science 2021-11-25 Yujia Zhou , Zhicheng Dou , Yutao Zhu , Ji-Rong Wen

Real-world recommendation systems commonly offer diverse content scenarios for users to interact with. Considering the enormous number of users in industrial platforms, it is infeasible to utilize a single unified recommendation model to…

Information Retrieval · Computer Science 2024-12-10 Chonggang Song , Chunxu Shen , Hao Gu , Yaoming Wu , Lingling Yi , Jie Wen , Chuan Chen

Prescriptive Process Monitoring (PresPM) recommends interventions during business processes to optimize key performance indicators (KPIs). In realistic settings, interventions are rarely isolated: organizations need to align sequences of…

Machine Learning · Computer Science 2026-01-12 Jakob De Moor , Hans Weytjens , Johannes De Smedt , Jochen De Weerdt

A growing number of universities worldwide use various forms of online and blended learning as part of their academic curricula. Furthermore, the recent changes caused by the COVID-19 pandemic have led to a drastic increase in importance…

Machine Learning · Computer Science 2022-09-05 Galina Deeva , Johannes De Smedt , Cecilia Saint-Pierre , Richard Weber , Jochen De Weerdt

Recent advances in pre-trained language models have improved the performance for text classification tasks. However, little attention is paid to the priority scheduling strategy on the samples during training. Humans acquire knowledge…

Computation and Language · Computer Science 2022-10-27 Xulong Zhang , Jianzong Wang , Ning Cheng , Jing Xiao

Strategic classification regards the problem of learning in settings where users can strategically modify their features to improve outcomes. This setting applies broadly and has received much recent attention. But despite its practical…

Machine Learning · Computer Science 2021-06-15 Sagi Levanon , Nir Rosenfeld

Problem-based learning (PBL) is a constructivist learner-centered instructional approach based on the analysis, resolution and discussion of a given problem. It can be applied to any subject, indeed it is especially useful for the teaching…

History and Overview · Mathematics 2011-11-17 Marina Cazzola

Accurately predicting their future performance can ensure students successful graduation, and help them save both time and money. However, achieving such predictions faces two challenges, mainly due to the diversity of students' background…

Computers and Society · Computer Science 2023-01-02 Khalid Moustapha Askia , Marie-Jean Meurs

End-to-end autonomous driving systems, predominantly trained through imitation learning, have demonstrated considerable effectiveness in leveraging large-scale expert driving data. Despite their success in open-loop evaluations, these…

Robotics · Computer Science 2025-11-12 Yi Huang , Zhan Qu , Lihui Jiang , Bingbing Liu , Hongbo Zhang

A dynamic treatment regime effectively incorporates both accrued information and long-term effects of treatment from specially designed clinical trials. As these become more and more popular in conjunction with longitudinal data from…

Methodology · Statistics 2011-08-29 Rui Song , Weiwei Wang , Donglin Zeng , Michael R. Kosorok

In recent years, the field of precision medicine has seen many advancements. Significant focus has been placed on creating algorithms to estimate individualized treatment rules (ITR), which map from patient covariates to the space of…

Methodology · Statistics 2021-12-09 Kushal S. Shah , Haoda Fu , Michael R. Kosorok

Reinforcement Learning (RL) is a computational approach to reward-driven learning in sequential decision problems. It implements the discovery of optimal actions by learning from an agent interacting with an environment rather than from…

Methodology · Statistics 2022-10-06 Mauricio Tec , Yunshan Duan , Peter Müller

Model tracing and constraint-based modeling are two approaches to diagnose student input in stepwise tasks. Model tracing supports identifying consecutive problem-solving steps taken by a student, whereas constraint-based modeling supports…

Artificial Intelligence · Computer Science 2025-07-21 Gerben van der Hoek , Johan Jeuring , Rogier Bos

Personalisation is a standard feature of conversational AI systems used by millions; yet, the efficacy of personalisation methods is often evaluated in academic research using simulated users rather than real people. This raises questions…

Computation and Language · Computer Science 2026-05-14 Hannah Rose Kirk , Liu Leqi , Fanzhi Zeng , Henry Davidson , Bertie Vidgen , Christopher Summerfield , Scott A. Hale

In-Context Learning (ICL) allows Large Language Models (LLMs) to adapt to new tasks with just a few examples, but their predictions often suffer from systematic biases, leading to unstable performance in classification. While calibration…

Machine Learning · Statistics 2026-03-05 Korel Gundem , Juncheng Dong , Dennis Zhang , Vahid Tarokh , Zhengling Qi

An individualized dose rule recommends a dose level within a continuous safe dose range based on patient level information such as physical conditions, genetic factors and medication histories. Traditionally, personalized dose finding…

Methodology · Statistics 2020-07-21 Liangyu Zhu , Wenbin Lu , Michael R. Kosorok , Rui Song