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Diffusion models show promise for 3D molecular generation, but face a fundamental trade-off between sampling efficiency and conformational accuracy. While flow-based models are fast, they often produce geometrically inaccurate structures,…

Chemical Physics · Physics 2025-12-05 Peining Zhang , Jinbo Bi , Minghu Song

Diffusion models have greatly improved visual generation but are hindered by slow generation speed due to the computationally intensive nature of solving generative ODEs. Rectified flow, a widely recognized solution, improves generation…

Computer Vision and Pattern Recognition · Computer Science 2024-10-14 Fu-Yun Wang , Ling Yang , Zhaoyang Huang , Mengdi Wang , Hongsheng Li

Diffusion-based generative models use stochastic differential equations (SDEs) and their equivalent ordinary differential equations (ODEs) to establish a smooth connection between a complex data distribution and a tractable prior…

Machine Learning · Computer Science 2024-08-25 Defang Chen , Zhenyu Zhou , Can Wang , Chunhua Shen , Siwei Lyu

Recent years have witnessed significant progress in developing effective training and fast sampling techniques for diffusion models. A remarkable advancement is the use of stochastic differential equations (SDEs) and their…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Defang Chen , Zhenyu Zhou , Jian-Ping Mei , Chunhua Shen , Chun Chen , Can Wang

The scarcity of annotated surgical data poses a significant challenge for developing deep learning systems in computer-assisted interventions. While diffusion models can synthesize realistic images, they often suffer from data memorization,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Danush Kumar Venkatesh , Stefanie Speidel

Adapting large-scale pre-trained generative models in a parameter-efficient manner is gaining traction. Traditional methods like low rank adaptation achieve parameter efficiency by imposing constraints but may not be optimal for tasks…

Computer Vision and Pattern Recognition · Computer Science 2024-06-03 Xinxi Zhang , Song Wen , Ligong Han , Felix Juefei-Xu , Akash Srivastava , Junzhou Huang , Hao Wang , Molei Tao , Dimitris N. Metaxas

Diffusion models have become a leading method for generative modeling of both image and scientific data. As these models are costly to train and \emph{evaluate}, reducing the inference cost for diffusion models remains a major goal.…

Machine Learning · Computer Science 2025-12-01 Haoxuan Chen , Yinuo Ren , Lexing Ying , Grant M. Rotskoff

Diffusion models with transformer architectures have demonstrated promising capabilities in generating high-fidelity images and scalability for high resolution. However, iterative sampling process required for synthesis is very…

Computer Vision and Pattern Recognition · Computer Science 2025-04-16 Yeongmin Kim , Sotiris Anagnostidis , Yuming Du , Edgar Schönfeld , Jonas Kohler , Markos Georgopoulos , Albert Pumarola , Ali Thabet , Artsiom Sanakoyeu

A popular approach to sample a diffusion-based generative model is to solve an ordinary differential equation (ODE). In existing samplers, the coefficients of the ODE solvers are pre-determined by the ODE formulation, the reverse discrete…

Machine Learning · Computer Science 2023-10-04 Guoqiang Zhang , Niwa Kenta , W. Bastiaan Kleijn

Diffusion models excel at image restoration via probabilistic modeling of forward noise addition and reverse denoising, and their ability to handle complex noise while preserving fine details makes them well-suited for Low-Light Image…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Ying Liu , Junchao Zhang , Caiyun Wu

Diffusion models have significantly improved the quality and diversity of audio generation but are hindered by slow inference speed. Rectified flow enhances inference speed by learning straight-line ordinary differential equation (ODE)…

Sound · Computer Science 2025-05-29 Junqi Zhao , Jinzheng Zhao , Haohe Liu , Yun Chen , Lu Han , Xubo Liu , Mark Plumbley , Wenwu Wang

Guided diffusion is a technique for conditioning the output of a diffusion model at sampling time without retraining the network for each specific task. One drawback of diffusion models, however, is their slow sampling process. Recent…

Computer Vision and Pattern Recognition · Computer Science 2023-01-30 Suttisak Wizadwongsa , Supasorn Suwajanakorn

Score-based generative models (SGMs) have recently emerged as a promising class of generative models. However, a fundamental limitation is that their inference is very slow due to a need for many (e.g., 2000) iterations of sequential…

Computer Vision and Pattern Recognition · Computer Science 2022-12-06 Hengyuan Ma , Li Zhang , Xiatian Zhu , Jianfeng Feng

Test-time adaptation (TTA) aims to improve the performance of source-domain pre-trained models on previously unseen, shifted target domains. Traditional TTA methods primarily adapt model weights based on target data streams, making model…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Jiayi Guo , Junhao Zhao , Chaoqun Du , Yulin Wang , Chunjiang Ge , Zanlin Ni , Shiji Song , Humphrey Shi , Gao Huang

Source-Free Unsupervised Domain Adaptation (SFUDA) is a challenging task where a model needs to be adapted to a new domain without access to target domain labels or source domain data. The primary difficulty in this task is that the model's…

Computer Vision and Pattern Recognition · Computer Science 2024-02-05 Yangyang Shu , Xiaofeng Cao , Qi Chen , Bowen Zhang , Ziqin Zhou , Anton van den Hengel , Lingqiao Liu

Test-Time Adaptation (TTA) adjusts models using unlabeled test data to handle dynamic distribution shifts. However, existing methods rely on frequent adaptation and high computational cost, making them unsuitable for resource-constrained…

Machine Learning · Computer Science 2025-11-20 Hyeongheon Cha , Dong Min Kim , Hye Won Chung , Taesik Gong , Sung-Ju Lee

Diffusion models are cutting-edge generative models adept at producing diverse, high-quality images. Despite their effectiveness, these models often require significant computational resources owing to their numerous sequential denoising…

Computer Vision and Pattern Recognition · Computer Science 2025-06-09 Hongtao Huang , Xiaojun Chang , Lina Yao

Diffusion models have shown remarkable promise for image restoration by leveraging powerful priors. Prominent methods typically frame the restoration problem within a Bayesian inference framework, which iteratively combines a denoising step…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Hongjie Wu , Mingqin Zhang , Linchao He , Ji-Zhe Zhou , Jiancheng Lv

Developing efficient multi-objective optimization methods to compute the Pareto set of optimal compromises between conflicting objectives remains a key challenge, especially for large-scale and expensive problems. To bridge this gap, we…

Machine Learning · Computer Science 2026-02-05 Sedjro Salomon Hotegni , Sebastian Peitz

Standard Latent Diffusion Models rely on a complex, three-part architecture consisting of a separate encoder, decoder, and diffusion network, which are trained in multiple stages. This modular design is computationally inefficient, leads to…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Xiyuan Wang , Muhan Zhang