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Multimodal large language models (MLLMs) have achieved significant success in the general field of image processing. Their emerging task generalization and freeform conversational capabilities can greatly facilitate medical diagnostic…

Image and Video Processing · Electrical Eng. & Systems 2024-09-17 Youzhu Jin , Yichen Zhang

Microwell microfluidics has been utilized for single-cell analysis to reveal heterogeneity in gene expression, signaling pathways, and phenotypic responses for identifying rare cell types, understanding disease progression, and developing…

Neurons and Cognition · Quantitative Biology 2025-10-17 Dinh-Nguyen Nguyen , Sadia Shakil , Raymond Kai-Yu Tong , Ngoc-Duy Dinh

Medical image segmentation driven by free-text clinical instructions is a critical frontier in computer-aided diagnosis. However, existing multimodal and foundation models struggle with the semantic ambiguity of clinical reports and fail to…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Chenyu Xue , Yiran Liu , Mian Zhou , Jionglong Su , Zhixiang Lu

This report relates to a study group hosted by the EPSRC funded network, Integrating data-driven BIOphysical models into REspiratory MEdicine (BIOREME), and supported by SofTMech and Innovate UK, Business Connect. This report summarises the…

Time series data from the Intensive Care Unit (ICU) provides critical information for patient monitoring. While recent advancements in applying Large Language Models (LLMs) to time series modeling (TSM) have shown great promise, their…

Machine Learning · Computer Science 2026-01-27 Feixiang Zheng , Yu Wu , Cecilia Mascolo , Ting Dang

Large Language Models (LLMs) have the potential to revolutionize data analytics by simplifying tasks such as data discovery and SQL query synthesis through natural language interactions. This work serves as a pivotal first step toward the…

Large language models (LLMs) hold significant potential for mental health support, capable of generating empathetic responses and simulating therapeutic conversations. However, existing LLM-based approaches often lack the clinical grounding…

Computation and Language · Computer Science 2025-11-04 He Hu , Yucheng Zhou , Juzheng Si , Qianning Wang , Hengheng Zhang , Fuji Ren , Fei Ma , Laizhong Cui , Qi Tian

Depression remains widely underdiagnosed and undertreated because stigma and subjective symptom ratings hinder reliable screening. To address this challenge, we propose a coarse-to-fine, multi-stage framework that leverages large language…

Artificial Intelligence · Computer Science 2026-04-14 Shiyu Teng , Jiaqing Liu , Hao Sun , Yu Li , Shurong Chai , Ruibo Hou , Tomoko Tateyama , Lanfen Lin , Yen-Wei Chen

Recent advancements in Multimodal Large Language Models (MLLMs) have greatly improved their abilities in image understanding. However, these models often struggle with grasping pixel-level semantic details, e.g., the keypoints of an object.…

Computer Vision and Pattern Recognition · Computer Science 2024-11-05 Jie Yang , Wang Zeng , Sheng Jin , Lumin Xu , Wentao Liu , Chen Qian , Ruimao Zhang

Acute stroke demands prompt diagnosis and treatment to achieve optimal patient outcomes. However, the intricate and irregular nature of clinical data associated with acute stroke, particularly blood pressure (BP) measurements, presents…

Human-Computer Interaction · Computer Science 2024-07-24 Jaeyoung Kim , Sihyeon Lee , Hyeon Jeon , Keon-Joo Lee , Hee-Joon Bae , Bohyoung Kim , Jinwook Seo

Time series anomaly detection (TSAD) plays a crucial role in various industries by identifying atypical patterns that deviate from standard trends, thereby maintaining system integrity and enabling prompt response measures. Traditional TSAD…

Computation and Language · Computer Science 2024-05-27 Jun Liu , Chaoyun Zhang , Jiaxu Qian , Minghua Ma , Si Qin , Chetan Bansal , Qingwei Lin , Saravan Rajmohan , Dongmei Zhang

Power system time series analytics is critical in understanding the system operation conditions and predicting the future trends. Despite the wide adoption of Artificial Intelligence (AI) tools, many AI-based time series analytical models…

Signal Processing · Electrical Eng. & Systems 2025-11-12 Zhenghao Zhou , Yiyan Li , Xinjie Yu , Runlong Liu , Zelin Guo , Zheng Yan , Mo-Yuen Chow , Yuqi Yang , Yang Xu

According to the World Health Organisation (WHO), 235 million people suffer from respiratory illnesses and four million people die annually due to air pollution. Regular lung health monitoring can lead to prognoses about deteriorating lung…

Large language models (LLMs) are rapidly being integrated into psychological research as research tools, evaluation targets, human simulators, and cognitive models. However, recent evidence reveals severe measurement unreliability:…

Human-Computer Interaction · Computer Science 2025-07-08 Zhicheng Lin

We present Clinical Prediction with Large Language Models (CPLLM), a method that involves fine-tuning a pre-trained Large Language Model (LLM) for clinical disease and readmission prediction. We utilized quantization and fine-tuned the LLM…

Computation and Language · Computer Science 2024-05-03 Ofir Ben Shoham , Nadav Rappoport

In recent years, pre-trained large language models (LLMs) have achieved tremendous success in the field of Natural Language Processing (NLP). Prior studies have primarily focused on general and generic domains, with relatively less research…

Respiratory diseases remain a leading cause of mortality worldwide, highlighting the need for faster and more accurate diagnostic tools. This work presents a novel approach leveraging digital stethoscope technology for automatic respiratory…

Signal Processing · Electrical Eng. & Systems 2024-03-19 Constantino Álvarez Casado , Manuel Lage Cañellas , Matteo Pedone , Xiaoting Wu , Le Nguyen , Miguel Bordallo López

This study aims to simulate real-world clinical scenarios to systematically evaluate the ability of Large Language Models (LLMs) to extract core medical information from patient chief complaints laden with noise and redundancy, and to…

Artificial Intelligence · Computer Science 2025-12-15 Yuan Shen , Xiaojun Wu , Linghua Yu

Automated molecular structure elucidation remains challenging, as existing approaches often depend on pre-compiled databases or restrict themselves to single spectroscopic modalities. Here we introduce SpectraLLM, a large language model…

Quantitative Methods · Quantitative Biology 2026-05-12 Yunyue Su , Jiahui Chen , Zao Jiang , Zhenyi Zhong , Liang Wang , Qiang Liu , Zhaoxiang Zhang

Recent advances in large language models (LLMs) have shown potential in clinical text summarization, but their ability to handle long patient trajectories with multi-modal data spread across time remains underexplored. This study…

Computation and Language · Computer Science 2025-09-08 Maya Kruse , Shiyue Hu , Nicholas Derby , Yifu Wu , Samantha Stonbraker , Bingsheng Yao , Dakuo Wang , Elizabeth Goldberg , Yanjun Gao
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