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Discovering high-entropy alloy (HEA) compositions that reliably form a target crystal phase is a high-dimensional inverse design problem that conventional trial-and-error experimentation and forward-only machine learning models cannot…

Materials Science · Physics 2026-03-13 Iman Peivaste , Salim Belouettar

The integration of large language models (LLMs) into materials science offers a transformative opportunity to streamline computational workflows, yet current agentic systems remain constrained by rigid, carefully crafted domain-specific…

Materials Science · Physics 2026-04-08 Fengxu Yang , Jack D. Evans

The parameterization of simulation-based models is a central yet laborious task in computational chemistry and physics, often driven by human intuition and manual iteration. Automating this task necessitates the definition of suitable…

A breakthrough in alloy design often requires comprehensive understanding in complex multi-component/multi-phase systems to generate novel material hypotheses. We introduce a modern data analytics workflow that leverages high-quality…

Materials Science · Physics 2019-04-10 Dongwon Shin , Yukinori Yamamoto , Michael P. Brady , Sangkeun Lee , J. Allen Haynes

The automation of chemical research through self-driving laboratories (SDLs) promises to accelerate scientific discovery, yet the reliability and granular performance of the underlying AI agents remain critical, under-examined challenges.…

Artificial Intelligence · Computer Science 2025-10-01 Gihan Panapitiya , Emily Saldanha , Heather Job , Olivia Hess

Combinatorial optimization algorithm is essential in computer-aided drug design by progressively exploring chemical space to design lead compounds with high affinity to target protein. However current methods face inherent challenges in…

Biomolecules · Quantitative Biology 2025-07-23 Hao Tuo , Yan Li , Xuanning Hu , Haishi Zhao , Xueyan Liu , Bo Yang

The automated generation of layouts is vital for embodied intelligence and autonomous systems, supporting applications from virtual environment construction to home robot deployment. Current approaches, however, suffer from spatial…

Materials properties depend strongly on chemical composition, i.e., the relative amounts of each chemical element. Changes in composition lead to entirely different chemical arrangements, which vary in complexity from perfectly ordered…

Materials Science · Physics 2025-06-24 Killian Sheriff , Daniel Xiao , Yifan Cao , Lewis R. Owen , Rodrigo Freitas

The FAIR principles have transformed how computational data and workflows are shared in materials research, yet existing repositories can only serve pre-computed entries -- broad coverage is perpetually incomplete and cannot adapt to new…

Materials Science · Physics 2026-05-01 Yang Hu , Vladyslav Turlo

Autonomous materials research systems allow scientists to fail smarter, learn faster, and spend less resources in their studies. As these systems grow in number, capability, and complexity, a new challenge arises - how will they work…

Multiagent Systems · Computer Science 2023-03-21 A. Gilad Kusne , Austin McDannald

Configuring the parameters of additive manufacturing processes for metal alloys is a challenging problem due to complex relationships between input parameters (e.g., laser power, scan speed) and quality of printed outputs. The standard…

Artificial Intelligence · Computer Science 2026-01-27 Azza Fadhel , Nathaniel W. Zuckschwerdt , Aryan Deshwal , Susmita Bose , Amit Bandyopadhyay , Jana Doppa

Large language models (LLMs) excel at solving complex tasks by executing agentic workflows composed of detailed instructions and structured operations. Yet, building general-purpose agents by manually embedding foundation models into…

Artificial Intelligence · Computer Science 2025-08-08 Chia-Tung Ho , Jing Gong , Xufeng Yao , Yunsheng Bai , Abhishek B Akkur , Haoxing Ren

Model finding, as embodied by SAT solvers and similar tools, is used widely, both in embedding settings and as a tool in its own right. For instance, tools like Alloy target SAT to enable users to incrementally define, explore, verify, and…

Computation and Language · Computer Science 2024-12-05 Siddhartha Prasad , Ben Greenman , Tim Nelson , Shriram Krishnamurthi

This manuscript introduces a new socio-inspired metaheuristic technique referred to as Leader-Advocate-Believer based optimization algorithm (LAB) for engineering and global optimization problems. The proposed algorithm is inspired by the…

Neural and Evolutionary Computing · Computer Science 2022-04-26 Ruturaj Reddy , Anand J Kulkarni , Ganesh Krishnasamy , Apoorva S Shastri , Amir H. Gandomi

Large language model (LLM) agents have demonstrated strong capabilities across diverse domains, yet automated agent design remains a significant challenge. Current automated agent design approaches are often constrained by limited search…

Computation and Language · Computer Science 2025-11-21 Yu Li , Lehui Li , Zhihao Wu , Qingmin Liao , Jianye Hao , Kun Shao , Fengli Xu , Yong Li

Prehistoric humans invented stone tools for specialized tasks by not just maximizing the tool's immediate goal-completion accuracy, but also increasing their confidence in the tool for later use under similar settings. This factor…

Robotics · Computer Science 2025-10-15 Ajith Anil Meera , Abian Torres , Pablo Lanillos

Autonomous experimentation enabled by artificial intelligence (AI) offers a new paradigm for accelerating scientific discovery. Non-equilibrium materials synthesis is emblematic of complex, resource-intensive experimentation whose…

Antibody lead optimization is inherently a multi-objective challenge in drug discovery. Achieving a balance between different drug-like properties is crucial for the development of viable candidates, and this search becomes exponentially…

Machine Learning · Computer Science 2026-04-16 Jackie Rao , Ferran Gonzalez Hernandez , Leon Gerard , Alexandra Gessner

Enhancing yield is recognized as a paramount driver to reducing production costs in semiconductor smart manufacturing. However, optimizing and ensuring high yield rates is a highly complex and technical challenge, especially while…

Computational Engineering, Finance, and Science · Computer Science 2024-03-20 Weihong Zhai , Xiupeng Shi , Yiik Diew Wong , Qing Han , Lisheng Chen

Over the last decade, the long-running endeavour to automate high-level processes in machine learning (ML) has risen to mainstream prominence, stimulated by advances in optimisation techniques and their impact on selecting ML…

Machine Learning · Computer Science 2022-03-30 David Jacob Kedziora , Katarzyna Musial , Bogdan Gabrys