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Safety analyses in terms of adverse events (AEs) are an important aspect of benefit-risk assessments of therapies. Compared to efficacy analyses AE analyses are often rather simplistic. The probability of an AE of a specific type is…
A sum-wise formulation is proposed for the Kaplan-Meier product limit estimator of partially right-censored survival data. The derived representation permits to write the population's estimator as a sum over its individual units'…
A plug-in estimator of entropy is the entropy of the distribution where probabilities of symbols or blocks have been replaced with their relative frequencies in the sample. Consistency and asymptotic unbiasedness of the plug-in estimator…
A novel and comprehensive methodology designed to tackle the challenges posed by extreme values in the context of random censorship is introduced. The main focus is on the analysis of integrals based on the product-limit estimator of…
We present the learned harmonic mean estimator with normalizing flows - a robust, scalable and flexible estimator of the Bayesian evidence for model comparison. Since the estimator is agnostic to sampling strategy and simply requires…
Many statistical estimands can expressed as continuous linear functionals of a conditional expectation function. This includes the average treatment effect under unconfoundedness and generalizations for continuous-valued and personalized…
Tuning parameters are parameters involved in an estimating procedure for the purpose of reducing the risk of some other estimator. Examples include the degree of penalization in penalized regression and likelihood problems, as well as the…
This article is concerned with proving the consistency of Efron's (1981) bootstrap for the Kaplan-Meier estimator on the whole support of a survival function. While other works address the asymptotic Gaussianity of the estimator itself…
The commonly used two-way fixed effects estimator is biased under correlated heterogeneity and can lead to misleading inference. The mean group estimator proposed by Pesaran and Smith (1995) is robust to correlated heterogeneity but…
In this paper we extend the construction of random walks with a prescribed Poisson boundary to the case of measures in the class of a generalized Gibbs state. The price for dropping the $\alpha$-quasiconformal assumptions is that we must…
The hazard ratio is routinely used as a summary measure to assess the treatment effect in clinical trials with time-to-event endpoints. It is frequently assumed as constant over time although this assumption often does not hold. When the…
The hazard ratio, typically estimated using Cox's famous proportional hazards model, is the most common effect measure used to describe the association or effect of a covariate on a time-to-event outcome. In recent years the hazard ratio…
It is well known that Cauchy problem for Laplace equations is an ill-posed problem in Hadamard's sense. Small deviations in Cauchy data may lead to large errors in the solutions. It is observed that if a bound is imposed on the solution,…
The generalization performance of a risk prediction model can be evaluated by its calibration, which measures the agreement between predicted and observed outcomes on external validation data. Here, methods for assessing the calibration of…
We investigate estimation of a normal mean matrix under the matrix quadratic loss. Improved estimation under the matrix quadratic loss implies improved estimation of any linear combination of the columns. First, an unbiased estimate of risk…
The Kaplan-Meier product-limit estimator is a simple and powerful tool in time to event analysis. An extension exists for populations stratified into cohorts where a population survival curve is generated by weighted averaging of…
Cox proportional hazards model with measurement error is investigated. In Kukush et al. (2011) [Journal of Statistical Research 45, 77-94] and Chimisov and Kukush (2014) [Modern Stochastics: Theory and Applications 1, 13-32] asymptotic…
In reliability and life testing studies, the topic of estimating hazard rate has received great attention in recent years since an estimate of hazard rate is a quite useful tool for making decisions. Some works have included nonparametric…
We investigate the arithmetic-harmonic inequality (AHI) index, a bounded and scale-invariant measure of dispersion for positive random variables, defined through the interplay between the mean and its reciprocal. We derive analytical…
Population attributable fractions aim to quantify the proportion of the cases of an outcome (for example, a disease) that would have been avoided had no individuals in the population been exposed to a given exposure. This quantity thus…