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The Blood-Oxygen-Level-Dependent (BOLD) signal of resting-state fMRI (rs-fMRI) records the temporal dynamics of intrinsic functional networks in the brain. However, existing deep learning methods applied to rs-fMRI either neglect the…

Machine Learning · Computer Science 2021-06-30 Soham Gadgil , Qingyu Zhao , Adolf Pfefferbaum , Edith V. Sullivan , Ehsan Adeli , Kilian M. Pohl

Functional Magnetic Resonance Imaging (fMRI) relies on multi-step data processing pipelines to accurately determine brain activity; among them, the crucial step of spatial smoothing. These pipelines are commonly suboptimal, given the local…

Computer Vision and Pattern Recognition · Computer Science 2017-10-03 Albert Vilamala , Kristoffer Hougaard Madsen , Lars Kai Hansen

Objective: New measures of human brain connectivity are needed to address gaps in the existing measures and facilitate the study of brain function, cognitive capacity, and identify early markers of human disease. Traditional approaches to…

Neurons and Cognition · Quantitative Biology 2023-08-28 Cooper J. Mellema , Albert Montillo

The brain's functional connectivity fluctuates over time instead of remaining steady in a stationary mode even during the resting state. This fluctuation establishes the dynamical functional connectivity that transitions in a non-random…

Neurons and Cognition · Quantitative Biology 2022-03-28 Shikuang Deng , Jingwei Li , B. T. Thomas Yeo , Shi Gu

In modern neuroscience, functional magnetic resonance imaging (fMRI) has been a crucial and irreplaceable tool that provides a non-invasive window into the dynamics of whole-brain activity. Nevertheless, fMRI is limited by hemodynamic…

Signal Processing · Electrical Eng. & Systems 2024-01-26 Yamin Li , Ange Lou , Ziyuan Xu , Shiyu Wang , Catie Chang

Whole-brain computational modeling based on structural connectivity has shown great promise in successfully simulating fMRI BOLD signals with temporal co-activation patterns that are highly similar to empirical functional connectivity…

Neurons and Cognition · Quantitative Biology 2019-11-14 Neda Kaboodvand , Martijn P van den Heuvel , Peter Fransson

Recent studies invoke the superiority of the multivariate Total Correlation concept over the conventional pairwise measures of functional connectivity in biological networks. Those seminal works certainly show that empirical measures of…

Neurons and Cognition · Quantitative Biology 2023-12-25 Qiang Li , Greg Ver Steeg , Jesus Malo

Recently, the potential of dynamic brain networks as a neuroimaging biomarkers for mental illnesses is being increasingly recognized. However, there are several unmet challenges in developing such biomarkers, including the need for methods…

Neurons and Cognition · Quantitative Biology 2019-10-10 Suprateek Kundu , Jin Ming , Jennifer Stevens

The study of correlations between brain regions is an important chapter of the analysis of large-scale brain spatiotemporal dynamics. In particular, novel methods suited to extract dynamic changes in mutual correlations are needed. Here we…

Neurons and Cognition · Quantitative Biology 2018-10-11 Jeremi K. Ochab , Wojciech Tarnowski , and Maciej A. Nowak , Dante R. Chialvo

Analysis of brain connectivity is important for understanding how information is processed by the brain. We propose a novel Bayesian vector autoregression (VAR) hierarchical model for analyzing brain connectivity in a resting-state fMRI…

Applications · Statistics 2021-12-09 Bertil Wegmann , Anders Lundquist , Anders Eklund , Mattias Villani

There has been an explosion of interest in functional Magnetic Resonance Imaging (MRI) during the past two decades. Naturally, this has been accompanied by many major advances in the understanding of the human connectome. These advances…

Machine Learning · Statistics 2016-10-31 Ricardo Pio Monti , Romy Lorenz , Christoforos Anagnostopoulos , Robert Leech , Giovanni Montana

Task functional magnetic resonance imaging (fMRI) is a type of neuroimaging data used to identify areas of the brain that activate during specific tasks or stimuli. These data are conventionally modeled using a massive univariate approach…

Methodology · Statistics 2022-11-04 Daniel A. Spencer , David Bolin , Amanda F. Mejia

Many analyses of functional magnetic resonance imaging (fMRI) examine functional connectivity (FC), or the statistical dependencies among distant brain regions. These analyses are typically exploratory, guiding future confirmatory research.…

Applications · Statistics 2025-10-20 Kyle Stanley , Nicole Lazar , Matthew Reimherr

Capturing dynamic spatiotemporal neural activity is essential for understanding large-scale brain mechanisms. Functional magnetic resonance imaging (fMRI) provides high-resolution cortical representations that form a strong basis for…

Image and Video Processing · Electrical Eng. & Systems 2026-04-01 Wanying Qu , Jianxiong Gao , Wei Wang , Yanwei Fu

A standard approach in functional neuroimaging explores how a particular cognitive task activates a set of brain regions (one task-to-many regions mapping). Importantly though, the same neural system can be activated by inherently different…

Neurons and Cognition · Quantitative Biology 2016-03-23 Romy Lorenz , Ricardo Pio Monti , Ines R. Violante , Christoforos Anagnostopoulos , Aldo A. Faisal , Giovanni Montana , Robert Leech

With the advances in high resolution neuroimaging, there has been a growing interest in the detection of functional brain connectivity. Complex network theory has been proposed as an attractive mathematical representation of functional…

Neural and Evolutionary Computing · Computer Science 2018-09-18 Arash Golibagh Mahyari , Selin Aviyente

In signal processing, exploring complex systems through network representations has become an area of growing interest. This study introduces the modularity graph, a new graph-based feature, to highlight the relationship across the graph…

Neurons and Cognition · Quantitative Biology 2024-10-23 Tiziana Cattai , Camilla Caporali , Marie-Constance Corsi , Stefania Colonnese

The problem of linking functional connectomics to behavior is extremely challenging due to the complex interactions between the two distinct, but related, data domains. We propose a coupled manifold optimization framework which projects…

Machine Learning · Computer Science 2020-07-07 Niharika Shimona D'Souza , Mary Beth Nebel , Nicholas Wymbs , Stewart Mostofsky , Archana Venkataraman

The human brain is a complex system, and understanding its mechanisms has been a long-standing challenge in neuroscience. The study of the functional connectome, which maps the functional connections between different brain regions, has…

Neural and Evolutionary Computing · Computer Science 2025-04-14 Tananun Songdechakraiwut , Yutong Wu

Functional magnetic resonance imaging (fMRI) enables indirect detection of brain activity changes via the blood-oxygen-level-dependent (BOLD) signal. Conventional analysis methods mainly rely on the real-valued magnitude of these signals.…

Methodology · Statistics 2023-10-31 Zhengxin Wang , Daniel B. Rowe , Xinyi Li , D. Andrew Brown
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