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Histopathology images are crucial to the study of complex diseases such as cancer. The histologic characteristics of nuclei play a key role in disease diagnosis, prognosis and analysis. In this work, we propose a sparse Convolutional…

Computer Vision and Pattern Recognition · Computer Science 2017-04-11 Le Hou , Vu Nguyen , Dimitris Samaras , Tahsin M. Kurc , Yi Gao , Tianhao Zhao , Joel H. Saltz

Mammography is crucial for breast cancer surveillance and early diagnosis. However, analyzing mammography images is a demanding task for radiologists, who often review hundreds of mammograms daily, leading to overdiagnosis and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Kun Zhao , Jakub Prokop , Javier Montalt Tordera , Sadegh Mohammadi

Masked autoencoders (MAEs) have displayed significant potential in the classification and semantic segmentation of medical images in the last year. Due to the high similarity of human tissues, even slight changes in medical images may…

Computer Vision and Pattern Recognition · Computer Science 2023-05-11 Jiawei Mao , Shujian Guo , Yuanqi Chang , Xuesong Yin , Binling Nie

Sparse Autoencoders (SAEs) are a powerful dictionary learning technique for decomposing neural network activations, translating the hidden state into human ideas with high semantic value despite no external intervention or guidance.…

Machine Learning · Computer Science 2025-12-17 Albert Miao , Chenliang Zhou , Jiawei Zhou , Cengiz Oztireli

This study explores the application of Convolutional Autoencoders (CAEs) for analyzing and reconstructing Scanning Tunneling Microscopy (STM) images of various crystalline lattice structures. We developed two distinct CAE architectures to…

Numerical Analysis · Mathematics 2025-01-24 Peter Binev , Joshua Moorehead , Ayush Parambath , Luke Parrella , Rori Pumphrey , Miruna Savu

The lack of large and diverse training data on Computer-Aided Diagnosis (CAD) in breast cancer detection has been one of the concerns that impedes the adoption of the system. Recently, pre-training with large-scale image text datasets via…

Image and Video Processing · Electrical Eng. & Systems 2024-05-24 Shantanu Ghosh , Clare B. Poynton , Shyam Visweswaran , Kayhan Batmanghelich

Disentangling model activations into meaningful features is a central problem in interpretability. However, the absence of ground-truth for these features in realistic scenarios makes validating recent approaches, such as sparse dictionary…

Machine Learning · Computer Science 2024-05-21 Aleksandar Makelov , George Lange , Neel Nanda

Advances in deep learning (DL) have resulted in impressive accuracy in some medical image classification tasks, but often deep models lack interpretability. The ability of these models to explain their decisions is important for fostering…

Explaining the decisions of Deep Neural Networks (DNNs) for medical images has become increasingly important. Existing attribution methods have difficulty explaining the meaning of pixels while existing concept-based methods are limited by…

Artificial Intelligence · Computer Science 2024-08-20 Weiji Kong , Xun Gong , Juan Wang

Sparse autoencoders (SAEs) trained on large language model activations output thousands of features that enable mapping to human-interpretable concepts. The current practice for analyzing these features primarily relies on inspecting…

Computation and Language · Computer Science 2026-03-26 Wilson E. Marcílio-Jr , Danilo M. Eler

Sparse Autoencoders (SAEs) are powerful tools for interpreting neural representations, yet their use in audio remains underexplored. We train SAEs across all encoder layers of Whisper and HuBERT, provide an extensive evaluation of their…

Motivated by the hypothesis that neural network representations encode abstract, interpretable features as linearly accessible, approximately orthogonal directions, sparse autoencoders (SAEs) have become a popular tool in interpretability.…

Machine Learning · Computer Science 2025-11-05 Valérie Costa , Thomas Fel , Ekdeep Singh Lubana , Bahareh Tolooshams , Demba Ba

Sparse autoencoders (SAEs) are a promising approach for uncovering interpretable features in large language models (LLMs). While several automated evaluation methods exist for SAEs, most rely on external LLMs. In this work, we introduce…

Computation and Language · Computer Science 2025-09-30 Alex Gulko , Yusen Peng , Sachin Kumar

Self-supervised models allow (pre-)training on unlabeled data and therefore have the potential to overcome the need for large annotated cohorts. One leading self-supervised model is the masked autoencoder (MAE) which was developed on…

Image and Video Processing · Electrical Eng. & Systems 2023-03-13 Daniel M. Lang , Eli Schwartz , Cosmin I. Bercea , Raja Giryes , Julia A. Schnabel

In the field of medical image segmentation, challenges such as indistinct lesion features, ambiguous boundaries,and multi-scale characteristics have long revailed. This paper proposes an improved method named Intensity-Spatial Dual Masked…

Image and Video Processing · Electrical Eng. & Systems 2025-02-17 Yuexing Ding , Jun Wang , Hongbing Lyu

Understanding what sparse auto-encoder (SAE) features in vision transformers truly represent is usually done by inspecting the patches where a feature's activation is highest. However, self-attention mixes information across the entire…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Sangyu Han , Yearim Kim , Nojun Kwak

We investigate whether sparse autoencoders (SAEs) can be used to remove knowledge from language models. We use the biology subset of the Weapons of Mass Destruction Proxy dataset and test on the gemma-2b-it and gemma-2-2b-it language…

Machine Learning · Computer Science 2024-11-05 Eoin Farrell , Yeu-Tong Lau , Arthur Conmy

Sparse autoencoders (SAEs) operationalise the linear representation hypothesis: they reconstruct model activations as sparse linear combinations of interpretable dictionary atoms, on the implicit assumption that activation space is well…

Machine Learning · Computer Science 2026-05-12 Eslam Zaher , Maciej Trzaskowski , Quan Nguyen , Fred Roosta

Identifying the features learned by neural networks is a core challenge in mechanistic interpretability. Sparse autoencoders (SAEs), which learn a sparse, overcomplete dictionary that reconstructs a network's internal activations, have been…

Machine Learning · Computer Science 2024-05-27 Dan Braun , Jordan Taylor , Nicholas Goldowsky-Dill , Lee Sharkey

Generative models of observations under interventions have been a vibrant topic of interest across machine learning and the sciences in recent years. For example, in drug discovery, there is a need to model the effects of diverse…

Machine Learning · Statistics 2024-01-17 Michael Bereket , Theofanis Karaletsos