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Decoding the linguistic intricacies of the genome is a crucial problem in biology, and pre-trained foundational models such as DNABERT and Nucleotide Transformer have made significant strides in this area. Existing works have largely hinged…

Genomics · Quantitative Biology 2024-03-20 Zhihan Zhou , Yanrong Ji , Weijian Li , Pratik Dutta , Ramana Davuluri , Han Liu

The best performing transformer-based language models use subword tokenization techniques, such as Byte-Pair-Encoding (BPE). However, these approaches often overlook linguistic principles, such as morphological segmentation, which we…

Computation and Language · Computer Science 2025-04-03 Mikkel Wildner Kildeberg , Emil Allerslev Schledermann , Nicolaj Larsen , Rob van der Goot

DNA language models have advanced genomics, but their downstream performance varies widely due to differences in tokenization, pretraining data, and architecture. We argue that a major bottleneck lies in tokenizing sparse and unevenly…

Genomics · Quantitative Biology 2025-12-23 Xiaoxiao Zhou , Zihan Wang , Jingbo Shang , Yang E. Li

This paper presents a novel hybrid tokenization strategy that enhances the performance of DNA Language Models (DLMs) by combining 6-mer tokenization with Byte Pair Encoding (BPE-600). Traditional k-mer tokenization is effective at capturing…

Computation and Language · Computer Science 2025-07-25 Ganesh Sapkota , Md Hasibur Rahman

Since self-attention layers in Transformers are permutation invariant by design, positional encodings must be explicitly incorporated to enable spatial understanding. However, fixed-size lookup tables used in traditional learnable position…

Machine Learning · Computer Science 2025-06-18 Huayang Li , Yahui Liu , Hongyu Sun , Deng Cai , Leyang Cui , Wei Bi , Peilin Zhao , Taro Watanabe

Length generalization, the ability to generalize from small training context sizes to larger ones, is a critical challenge in the development of Transformer-based language models. Positional encoding (PE) has been identified as a major…

Computation and Language · Computer Science 2023-11-08 Amirhossein Kazemnejad , Inkit Padhi , Karthikeyan Natesan Ramamurthy , Payel Das , Siva Reddy

Positional encoding plays a crucial role in transformers, significantly impacting model performance and length generalization. Prior research has introduced absolute positional encoding (APE) and relative positional encoding (RPE) to…

Computation and Language · Computer Science 2024-11-06 Chuanyang Zheng , Yihang Gao , Han Shi , Minbin Huang , Jingyao Li , Jing Xiong , Xiaozhe Ren , Michael Ng , Xin Jiang , Zhenguo Li , Yu Li

The emergence of telomere-to-telomere (T2T) genome assemblies has opened new avenues for comparative genomics, yet effective tokenization strategies for genomic sequences remain underexplored. In this pilot study, we apply Byte Pair…

Genomics · Quantitative Biology 2025-05-15 Marina Popova , Iaroslav Chelombitko , Aleksey Komissarov

In this paper, we give an in-depth analysis on the mathematical problem formulations and the probabilistic optimization explorations for some of the key components in Transformer model [33] in the field of generative AI. We explore and…

Machine Learning · Computer Science 2024-10-25 Fulu Li

Positional encoding mechanisms enable Transformers to model sequential structure and long-range dependencies in text. While absolute positional encodings struggle with extrapolation to longer sequences due to fixed positional…

Computation and Language · Computer Science 2025-09-09 Chang Dai , Hongyu Shan , Mingyang Song , Di Liang

Subword tokenization methods, such as Byte-Pair Encoding (BPE), significantly impact the performance and efficiency of large language models (LLMs). The standard approach involves training a general-purpose tokenizer that uniformly…

Computation and Language · Computer Science 2026-01-30 Vijini Liyanage , François Yvon

Traditional greedy tokenization methods have been a critical step in Natural Language Processing (NLP), influencing how text is converted into tokens and directly impacting model performance. While subword tokenizers like Byte-Pair Encoding…

Computation and Language · Computer Science 2025-05-05 Bharath Raj , Garvit Suri , Vikrant Dewangan , Raghav Sonavane

Tokenization is a foundational step in natural language processing (NLP) tasks, bridging raw text and language models. Existing tokenization approaches like Byte-Pair Encoding (BPE) originate from the field of data compression, and it has…

Computation and Language · Computer Science 2024-10-08 Craig W. Schmidt , Varshini Reddy , Haoran Zhang , Alec Alameddine , Omri Uzan , Yuval Pinter , Chris Tanner

In Transformer-based architectures, the attention mechanism is inherently permutation-invariant with respect to the input sequence's tokens. To impose sequential order, token positions are typically encoded using a scheme with either fixed…

Machine Learning · Computer Science 2023-10-31 Giorgio Angelotti

Recent studies have demonstrated the effectiveness of position encoding in transformer architectures. By incorporating positional information, this approach provides essential guidance for modeling dependencies between elements across…

Machine Learning · Computer Science 2025-08-27 Avinash Amballa

Transformer architectures rely on position encodings to model the spatial structure of input data. Rotary Position Encoding (RoPE) is a widely used method in language models that encodes relative positions through fixed, block-diagonal,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Sophie Ostmeier , Brian Axelrod , Maya Varma , Michael E. Moseley , Akshay Chaudhari , Curtis Langlotz

Auto-regressive neural sequence models have been shown to be effective across text generation tasks. However, their left-to-right decoding order prevents generation from being parallelized. Insertion Transformer (Stern et al., 2019) is an…

Computation and Language · Computer Science 2023-02-01 Zhisong Zhang , Yizhe Zhang , Bill Dolan

Recurrent models have been dominating the field of neural machine translation (NMT) for the past few years. Transformers \citep{vaswani2017attention}, have radically changed it by proposing a novel architecture that relies on a feed-forward…

Computation and Language · Computer Science 2022-10-25 Joyce Zheng , Mehdi Rezagholizadeh , Peyman Passban

Transformers rely on both content-based and position-based addressing mechanisms to make predictions, but existing positional encoding techniques often diminish the effectiveness of position-based addressing. Many current methods enforce…

Computation and Language · Computer Science 2025-08-22 Jiajun Zhu , Peihao Wang , Ruisi Cai , Jason D. Lee , Pan Li , Zhangyang Wang

Position encoding recently has shown effective in the transformer architecture. It enables valuable supervision for dependency modeling between elements at different positions of the sequence. In this paper, we first investigate various…

Computation and Language · Computer Science 2023-11-09 Jianlin Su , Yu Lu , Shengfeng Pan , Ahmed Murtadha , Bo Wen , Yunfeng Liu
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