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Representation learning from Gigapixel Whole Slide Images (WSI) poses a significant challenge in computational pathology due to the complicated nature of tissue structures and the scarcity of labeled data. Multi-instance learning methods…

Image and Video Processing · Electrical Eng. & Systems 2024-05-28 Ali Nasiri-Sarvi , Vincent Quoc-Huy Trinh , Hassan Rivaz , Mahdi S. Hosseini

Despite recent efforts in understanding the compression impact on large language models (LLMs) in terms of their downstream task performance and trustworthiness on relatively simpler uni-modal benchmarks (for example, question answering,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-10 Souvik Kundu , Anahita Bhiwandiwalla , Sungduk Yu , Phillip Howard , Tiep Le , Sharath Nittur Sridhar , David Cobbley , Hao Kang , Vasudev Lal

Despite being widely used to support clinical care, general-purpose large multimodal models (LMMs) have generally shown poor or inconclusive performance in medical image interpretation, particularly in pathology, where gigapixel images are…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Thomas A. Buckley , Kian R. Weihrauch , Katherine Latham , Andrew Z. Zhou , Padmini A. Manrai , Arjun K. Manrai

Whole slide images are the foundation of digital pathology for the diagnosis and treatment of carcinomas. Writing pathology reports is laborious and error-prone for inexperienced pathologists. To reduce the workload and improve clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-06-28 Pingyi Chen , Honglin Li , Chenglu Zhu , Sunyi Zheng , Zhongyi Shui , Lin Yang

Large Language Models (LLMs) have demonstrated remarkable proficiency in language comprehension and generation; however, their widespread adoption is constrained by substantial bandwidth and computational demands. While pruning and low-rank…

Computation and Language · Computer Science 2025-10-31 Zeliang Zong , Kai Zhang , Zheyang Li , Wenming Tan , Ye Ren , Yiyan Zhai , Jilin Hu

Although Large Vision Language Models (LVLMs) have demonstrated impressive multimodal reasoning capabilities, their scalability and deployment are constrained by massive computational requirements. In particular, the massive amount of…

Machine Learning · Computer Science 2026-04-14 Surendra Pathak , Bo Han

The Transformer architecture has significantly advanced natural language processing (NLP) and has been foundational in developing large language models (LLMs) such as LLaMA and OPT, which have come to dominate a broad range of NLP tasks.…

Artificial Intelligence · Computer Science 2024-03-27 Youpeng Zhao , Di Wu , Jun Wang

In this paper, we introduce LightVLM, a simple but effective method that can be seamlessly deployed upon existing Vision-Language Models (VLMs) to greatly accelerate the inference process in a training-free manner. We divide the inference…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Lianyu Hu , Fanhua Shang , Wei Feng , Liang Wan

Recent advances in multimodal large language models (LLMs) have highlighted their potential for medical and surgical applications. However, existing surgical datasets predominantly adopt a Visual Question Answering (VQA) format with…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Tae-Min Choi , Tae Kyeong Jeong , Garam Kim , Jaemin Lee , Yeongyoon Koh , In Cheul Choi , Jae-Ho Chung , Jong Woong Park , Juyoun Park

Streaming Video Large Language Models (VideoLLMs) have demonstrated impressive performance across various video understanding tasks, but they face significant challenges in real-time deployment due to the high computational cost of…

Computer Vision and Pattern Recognition · Computer Science 2026-02-12 Yiyu Wang , Xuyang Liu , Xiyan Gui , Xinying Lin , Boxue Yang , Chenfei Liao , Tailai Chen , Linfeng Zhang

Multimodal Large Language Models (MLLMs) have shown remarkable versatility in understanding diverse multimodal data and tasks. However, these capabilities come with an increased model scale. While post-training pruning reduces model size in…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Jaewoo Lee , Keyang Xuan , Chanakya Ekbote , Sandeep Polisetty , Yi R. Fung , Paul Pu Liang

Multimodal large language models (MLLMs) have emerged as powerful tools for computational pathology, offering unprecedented opportunities to integrate pathological images with language context for comprehensive diagnostic analysis. These…

Image and Video Processing · Electrical Eng. & Systems 2025-08-20 Zhe Xu , Ziyi Liu , Junlin Hou , Jiabo Ma , Cheng Jin , Yihui Wang , Zhixuan Chen , Zhengyu Zhang , Fuxiang Huang , Zhengrui Guo , Fengtao Zhou , Yingxue Xu , Xi Wang , Ronald Cheong Kin Chan , Li Liang , Hao Chen

Whole slide images (WSI) are microscopy images of stained tissue slides routinely prepared for diagnosis and treatment selection in medical practice. WSI are very large (gigapixel size) and complex (made of up to millions of cells). The…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Tristan Lazard , Marvin Lerousseau , Etienne Decencière , Thomas Walter

Large language models (LLMs) and their multimodal variants can now process visual inputs, including images of text. This raises an intriguing question: can we compress textual inputs by feeding them as images to reduce token usage while…

Computation and Language · Computer Science 2025-10-23 Yanhong Li , Zixuan Lan , Jiawei Zhou

Large Language Models (LLMs) face significant deployment challenges due to their substantial memory requirements and the computational demands of auto-regressive text generation process. This paper addresses these challenges by focusing on…

Machine Learning · Computer Science 2024-02-21 Yuxuan Yue , Zhihang Yuan , Haojie Duanmu , Sifan Zhou , Jianlong Wu , Liqiang Nie

Presenting whole slide images (WSIs) as graph will enable a more efficient and accurate learning framework for cancer diagnosis. Due to the fact that a single WSI consists of billions of pixels and there is a lack of vast annotated datasets…

Image and Video Processing · Electrical Eng. & Systems 2023-06-09 Milan Aryal , Nasim Yahyasoltani

Contrastive Language-Image Pretraining (CLIP) excels at learning generalizable image representations but often falls short in zero-shot inference on certain downstream datasets. Test-time adaptation (TTA) mitigates this issue by adjusting…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Zixin Wang , Dong Gong , Sen Wang , Zi Huang , Yadan Luo

While Large Language Models (LLMs) can theoretically support extensive context windows, their actual deployment is constrained by the linear growth of Key-Value (KV) cache memory. Prevailing compression strategies mitigate this through…

Artificial Intelligence · Computer Science 2026-02-03 Aryan Sood , Tanvi Sharma , Vansh Agrawal

Most Video-Large Language Models (Video-LLMs) adopt an encoder-decoder framework, where a vision encoder extracts frame-wise features for processing by a language model. However, this approach incurs high computational costs, introduces…

Computer Vision and Pattern Recognition · Computer Science 2025-11-06 Handong Li , Yiyuan Zhang , Longteng Guo , Xiangyu Yue , Jing Liu

As Large Language Models (LLMs) scale to handle massive concurrent traffic, optimizing the infrastructure required for inference has become a primary challenge. To manage the high cost of GPU resources while ensuring strict service-level…