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Biomedical knowledge graphs (KGs) encode vast, heterogeneous information spanning literature, genes, pathways, drugs, diseases, and clinical trials, but leveraging them collectively for scientific discovery remains difficult. Their…

Information Retrieval · Computer Science 2026-01-21 Zifeng Wang , Zheng Chen , Ziwei Yang , Xuan Wang , Qiao Jin , Yifan Peng , Zhiyong Lu , Jimeng Sun

Knowledge Graphs (KG) are the backbone of many data-intensive applications since they can represent data coupled with its meaning and context. Aligning KGs across different domains and providers is necessary to afford a fuller and…

Artificial Intelligence · Computer Science 2023-10-12 Pedro Giesteira Cotovio , Ernesto Jimenez-Ruiz , Catia Pesquita

Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

Quantitative Methods · Quantitative Biology 2025-11-14 Guofeng Meng , Li Shen , Qiuyan Zhong , Wei Wang , Haizhou Zhang , Xiaozhen Wang

The task of completing knowledge triplets has broad downstream applications. Both structural and semantic information plays an important role in knowledge graph completion. Unlike previous approaches that rely on either the structures or…

Computation and Language · Computer Science 2022-09-20 Jianhao Shen , Chenguang Wang , Linyuan Gong , Dawn Song

Large Language Models (LLMs) often suffer from hallucinations, which Retrieval-Augmented Generation (RAG) and GraphRAG mitigate by incorporating external knowledge and knowledge graphs (KGs). However, GraphRAG remains text-centric due to…

Artificial Intelligence · Computer Science 2026-03-11 Xueyao Wan , Hang Yu

Currently, there is a rapidly increasing need for high-quality biomedical knowledge graphs (BioKG) that provide direct and precise biomedical knowledge. In the context of COVID-19, this issue is even more necessary to be highlighted.…

Artificial Intelligence · Computer Science 2020-12-03 Sendong Zhao , Bing Qin , Ting Liu , Fei Wang

In recent years, there has been substantial progress in using pretrained Language Models (LMs) on a range of tasks aimed at improving the understanding of biomedical texts. Nonetheless, existing biomedical LLMs show limited comprehension of…

Computation and Language · Computer Science 2025-09-10 Andrey Sakhovskiy , Elena Tutubalina

Knowledge Graph Foundation Models (KGFMs) have shown promise in enabling zero-shot reasoning over unseen graphs by learning transferable patterns. However, most existing KGFMs rely solely on graph structure, overlooking the rich semantic…

Computation and Language · Computer Science 2025-09-22 Arvindh Arun , Sumit Kumar , Mojtaba Nayyeri , Bo Xiong , Ponnurangam Kumaraguru , Antonio Vergari , Steffen Staab

Biomedical networks (or graphs) are universal descriptors for systems of interacting elements, from molecular interactions and disease co-morbidity to healthcare systems and scientific knowledge. Advances in artificial intelligence,…

Machine Learning · Computer Science 2025-02-07 Michelle M. Li , Kexin Huang , Marinka Zitnik

With the rapid development of biomedical software and hardware, a large amount of relational data interlinking genes, proteins, chemical components, drugs, diseases, and symptoms has been collected for modern biomedical research. Many…

Artificial Intelligence · Computer Science 2021-01-21 Yankai Chen , Yaozu Wu , Shicheng Ma , Irwin King

Here we present a holistic approach for data exploration on dense knowledge graphs as a novel approach with a proof-of-concept in biomedical research. Knowledge graphs are increasingly becoming a vital factor in knowledge mining and…

Artificial Intelligence · Computer Science 2019-12-16 Jens Dörpinghaus , Alexander Apke , Vanessa Lage-Rupprecht , Andreas Stefan

Feature selection in Knowledge Graphs (KGs) are increasingly utilized in diverse domains, including biomedical research, Natural Language Processing (NLP), and personalized recommendation systems. This paper delves into the methodologies…

Machine Learning · Computer Science 2024-06-24 Sisi Shao , Pedro Henrique Ribeiro , Christina Ramirez , Jason H. Moore

Currently, the main approach for Large Language Models (LLMs) to tackle the hallucination issue is incorporating Knowledge Graphs(KGs).However, LLMs typically treat KGs as plain text, extracting only semantic information and limiting their…

Computation and Language · Computer Science 2025-09-29 Yifang Zhang , Pengfei Duan , Yiwen Yang , Shengwu Xiong

Biomedical knowledge graphs (BKGs) have emerged as powerful tools for organizing and leveraging the vast and complex data found across the biomedical field. Yet, current reviews of BKGs often limit their scope to specific domains or…

Computation and Language · Computer Science 2025-01-23 Yuxing Lu , Sin Yee Goi , Xukai Zhao , Jinzhuo Wang

Knowledge graphs (KGs), as structured representations of real world facts, are intelligent databases incorporating human knowledge that can help machine imitate the way of human problem solving. However, KGs are usually huge and there are…

Machine Learning · Computer Science 2023-06-27 Haotian Li , Hongri Liu , Yao Wang , Guodong Xin , Yuliang Wei

Knowledge Graphs (KGs) have gained considerable attention recently from both academia and industry. In fact, incorporating graph technology and the copious of various graph datasets have led the research community to build sophisticated…

Artificial Intelligence · Computer Science 2020-06-03 Bilal Abu-Salih , Marwan Al-Tawil , Ibrahim Aljarah , Hossam Faris , Pornpit Wongthongtham

The way we analyse clinical texts has undergone major changes over the last years. The introduction of language models such as BERT led to adaptations for the (bio)medical domain like PubMedBERT and ClinicalBERT. These models rely on large…

Computation and Language · Computer Science 2023-09-15 Tom van Sonsbeek , Xiantong Zhen , Marcel Worring

Knowledge Graph Embedding (KGE) models are used to learn continuous representations of entities and relations. A key task in the literature is predicting missing links between entities. However, Knowledge Graphs are not just sets of links…

Artificial Intelligence · Computer Science 2023-08-28 Thiviyan Thanapalasingam , Emile van Krieken , Peter Bloem , Paul Groth

Recent advances in natural language processing (NLP) owe their success to pre-training language models on large amounts of unstructured data. Still, there is an increasing effort to combine the unstructured nature of LMs with structured…

Computation and Language · Computer Science 2023-12-22 Juraj Vladika , Alexander Fichtl , Florian Matthes

Modern distributed decision-making systems face significant challenges arising from data heterogeneity, dynamic environments, and the need for decentralized coordination. This paper introduces the Knowledge Sharing paradigm as an innovative…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-10 Rosario Napoli , Gabriele Morabito , Antonio Celesti , Massimo Villari , Maria Fazio