English
Related papers

Related papers: Computations Meet Experiments to Advance the Enzym…

200 papers

Scientific workflows have become essential for orchestrating complex computational processes across distributed resources, managing large datasets, and ensuring reproducibility in modern research. The Workflows Community Summit 2025, held…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-06 Irene Bonati , Silvina Caino-Lores , Tainã Coleman , Sagar Dolas , Sandro Fiore , Venkatesh Kannan , Marco Verdicchio , Sean R. Wilkinson , Rafael Ferreira da Silva

Accurate modelling of electrostatic interactions and charge transfer is fundamental to computational chemistry, yet most machine learning interatomic potentials (MLIPs) rely on local atomic descriptors that cannot capture long-range…

To reduce the carbon footprint of computing and stabilize electricity grids, there is an increasing focus on approaches that align the power usage of IT infrastructure with the availability of clean energy. Unfortunately, research on…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-06-21 Philipp Wiesner , Ilja Behnke , Paul Kilian , Marvin Steinke , Odej Kao

This volume contains the proceedings of the Seventh International Workshop on Computing with Terms and Graphs (TERMGRAPH 2013). The workshop took place in Rome, Italy, on March 23rd, 2013, as part of the sixteenth edition of the European…

Symbolic Computation · Computer Science 2013-02-26 Rachid Echahed , Detlef Plump

We apply a number of atomic decomposition schemes across the standard QM7 dataset -- a small model set of organic molecules at equilibrium geometry -- to inspect the possible emergence of trends among contributions to atomization energies…

Chemical Physics · Physics 2023-04-19 Frederik Ø. Kjeldal , Janus J. Eriksen

The pursuit of advanced polymers for energy technologies, spanning photovoltaics, solid-state batteries, and hydrogen storage, is hindered by fragmented data ecosystems that fail to capture the hierarchical complexity of these materials.…

Soft Condensed Matter · Physics 2025-05-21 Ying Zhao , Guanhua Chen , Jie Liu

Generative molecular design has moved from proof-of-concept to real-world applicability, as marked by the surge in very recent papers reporting experimental validation. Key challenges in explainability and sample efficiency present…

Biomolecules · Quantitative Biology 2024-03-05 Jeff Guo , Philippe Schwaller

Enzymes are important proteins that catalyze chemical reactions. In recent years, machine learning methods have emerged to predict enzyme function from sequence; however, there are no standardized benchmarks to evaluate these methods. We…

Biomolecules · Quantitative Biology 2025-06-13 Jason Yang , Ariane Mora , Shengchao Liu , Bruce J. Wittmann , Anima Anandkumar , Frances H. Arnold , Yisong Yue

The compounding of plastics with recycled material remains a practical challenge, as the properties of the processed material is not as easy to control as with completely new raw materials. For a data scientist, it makes sense to plan the…

Human-Computer Interaction · Computer Science 2025-11-21 Dorina Weichert , Gunar Ernis , Marvin Worthmann , Peter Ryzko , Lukas Seifert

Despite decades of research, the ultimate goal of nanotechnology--top-down manipulation of individual atoms--has been directly achieved with only one technique: scanning probe microscopy. In this Review, we demonstrate that scanning…

Computational modeling is usually applied to aid experimental exploration of advanced materials to better understand the fundamental plasticity mechanisms during mechanical testing. In this work, we perform Molecular dynamics (MD)…

This review describes recent advances by the authors and others on the topic of incorporating experimental data into molecular simulations through maximum entropy methods. Methods which incorporate experimental data improve accuracy in…

Chemical Physics · Physics 2019-05-15 Dilnoza B. Amirkulova , Andrew D. White

In this paper, we present a study on how to develop an efficient multiscale simulation strategy for the dynamics of chemically active systems on low-dimensional supports. Such reactions are encountered in a wide variety of situations,…

Computational Physics · Physics 2015-06-04 Giacomo Mazzi , Yannick De Decker , Giovanni Samaey

Scientific research in many fields routinely requires the analysis of large datasets, and scientists often employ workflow systems to leverage clusters of computers for their data analysis. However, due to their size and scale, these…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-06-05 Lauritz Thamsen , Yehia Elkhatib , Paul Harvey , Syed Waqar Nabi , Jeremy Singer , Wim Vanderbauwhede

Genome editing allows scientists to change an organism's DNA. One promising genome editing protocol, already validated in living organisms, is based on clustered regularly interspaced short palindromic repeats (CRISPR)/Cas protein-nucleic…

Biological Physics · Physics 2019-07-25 Angana Ray , Rosa Di Felice

Scalable and efficient numerical simulations continue to gain importance, as computation is firmly established as the third pillar of discovery, alongside theory and experiment. Meanwhile, the performance of computing hardware grows through…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-06-26 Pietro Incardona , Antonio Leo , Yaroslav Zaluzhnyi , Rajesh Ramaswamy , Ivo F. Sbalzarini

Computer simulations have long been key to understanding and designing phase-change materials (PCMs) for memory technologies. Machine learning is now increasingly being used to accelerate the modelling of PCMs, and yet it remains…

Materials Science · Physics 2025-02-13 Yuxing Zhou , Daniel F. Thomas du Toit , Stephen R. Elliott , Wei Zhang , Volker L. Deringer

Accumulation of plastic waste is a major environmental problem. Enzymes, particularly esterases, play an important role in the biodegradation of polyesters. These enzymes are usually only active on aliphatic polyesters, but a few have…

Biomolecules · Quantitative Biology 2019-04-01 Beatriz C. Almeida , Pedro Figueiredo , Alexandra T. P. Carvalho

To directly simulate rare events using atomistic molecular dynamics is a significant challenge in computational biophysics. Well-established enhanced-sampling techniques do exist to obtain the thermodynamic functions for such systems. But…

Statistical Mechanics · Physics 2020-07-21 Dhiman Ray , Ioan Andricioaei

Numerical simulations underpin much fluid dynamics research today. Such simulations often rely on large scale high performance computing (HPC) systems, and have a significant carbon footprint. Increasing the efficiency of data centers or…

Physics and Society · Physics 2025-01-23 Miranda van Heel , Jack R. C. King