Related papers: A hierarchy of blood vessel models, Part I: 3D-1D …
We propose and analyze a hierarchy of three models of blood perfusion through a tissue surrounding a thin arteriole or venule. Our goal is to rigorously link 3D-3D Darcy--Stokes, 3D-1D Darcy--Poiseuille, and 1D Green's function methods…
In this work, we present mixed dimensional models for simulating blood flow and transport processes in breast tissue and the vascular tree supplying it. These processes are considered, to start from the aortic inlet to the capillaries and…
One-dimensional (1D) blood flow simulations are extensively used in cardiovascular research due to their computational efficiency and effectiveness in analyzing pulse wave dynamics. Despite their versatility and simplicity, there is a lack…
In this paper, we are concerned with the simulation of blood flow in microvascular networks and the surrounding tissue. To reduce the computational complexity of this issue, the network structures are modeled by a one-dimensional graph,…
Blood flow in arterial systems can be described by the three-dimensional Navier-Stokes equations within a time-dependent spatial domain that accounts for the elasticity of the arterial walls. In this article blood is treated as an…
We present a new method for modeling tissue perfusion on the capillary scale. The microvasculature is represented by a network of one-dimensional vessel segments embedded in the extra-vascular space. Vascular and extra-vascular space…
We study perfusion by a multiscale model coupling diffusion in the tissue and diffusion along the one-dimensional segments representing the vasculature. We propose a block-diagonal preconditioner for the model equations and demonstrate its…
In this paper, we introduce an adapted one-dimensional (1D) reduced model aimed at analyzing blood flow within stenosed arteries. Differing from the prevailing 1D model \cite{Formaggia2003, Sherwin2003_2, Sherwin2003, Quarteroni2004,…
A noteworthy aspect in blood flow modeling is the definition of the mechanical interaction between the fluid flow and the biological structure that contains it, namely the vessel wall. It has been demonstrated that the addition of a viscous…
A new two-dimensional model for blood flows in arteries with arbitrary cross sections is derived. The model consists of a system of balance laws for conservation of mass and balance of momentum in the axial and angular directions. The…
The goal of this paper is to investigate the validity of a hybrid embedded/homogenized in-silico approach for modeling perfusion through solid tumors. The rationale behind this novel idea is that only the larger blood vessels have to be…
In this paper, a pore-scale network modeling method, based on the flow continuity residual in conjunction with a Newton-Raphson non-linear iterative solving technique, is proposed and used to obtain the pressure and flow fields in a network…
Two aspects of a widely used 1D model of blood flow in a single blood vessel are studied by symmetry analysis, where the variables in the model are the blood pressure and the cross-section area of the blood vessel. As one main result, all…
Mathematical models and numerical simulations are widely used in the field of hemodynamics, representing a valuable resource to better understand physiological and pathological processes. The theory behind the phenomenon is closely related…
In this paper, a multiscale constitutive framework for one-dimensional blood flow modeling is presented and discussed. By analyzing the asymptotic limits of the proposed model, it is shown that different types of blood propagation phenomena…
Stents are medical devices designed to modify blood flow in aneurysm sacs, in order to prevent their rupture. Some of them can be considered as a locally periodic rough boundary. In order to approximate blood flow in arteries and vessels of…
Tumor growth beyond a critical size relies on the development of a functional vascular network, which ensures adequate oxygen and nutrient supply. In this work, we present a modeling framework based on an optimization-based 3D-1D coupling…
The choice of appropriate boundary conditions is a crucial step in the development of cardiovascular models for blood flow simulations. The three-element Windkessel model is usually employed as a lumped boundary condition, providing a…
The paper deals with modeling the liver perfusion intended to improve quantitative analysis of the tissue scans provided by the contrast-enhanced computed tomography (CT). For this purpose, we developed a model of dynamic transport of the…
Microvessels -blood vessels with diameter less than 200 microns- form large, intricate networks organized into arterioles, capillaries and venules. In these networks, the distribution of flow and pressure drop is a highly interlaced…