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The tumor microenvironment (TME) is a spatially heterogeneous ecosystem where cellular interactions shape tumor progression and response to therapy. Multiplexed imaging technologies enable high-resolution spatial characterization of the…

Applications · Statistics 2025-04-04 Joel Eliason , Arvind Rao , Timothy L Frankel , Michele Peruzzi

We study an individual-based stochastic spatial epidemic model where the number of locations and the number of individuals at each location both grow to infinity. Each individual is associated with a random infection-age dependent…

Probability · Mathematics 2025-10-21 Guodong Pang , Etienne Pardoux

Verbal autopsies (VAs) are extensively used to investigate the population-level distributions of deaths by cause in low-resource settings without well-organized vital statistics systems. Computer-based methods are often adopted to assign…

Applications · Statistics 2024-03-20 Tsuyoshi Kunihama , Zehang Richard Li , Samuel J. Clark , Tyler H. McCormick

The monitoring of conflict risk in the humanitarian sector is largely based on simple historic averages. The overarching goal of this work is to assess the potential for using a more statistically rigorous approach to monitor the risk of…

Applications · Statistics 2026-02-04 Raiha Browning , Hamish Patten , Judith Rousseau , Kerrie Mengersen

In Fall 2020, several European countries reported rapid increases in COVID-19 cases along with growing estimates of the effective reproduction rates. Such an acceleration in epidemic spread is usually attributed to time-dependent effects,…

Populations and Evolution · Quantitative Biology 2022-11-30 Nazmi Burak Budanur , Björn Hof

We present a novel approach for the analysis of multivariate case-control georeferenced data using Bayesian inference in the context of disease mapping, where the spatial distribution of different types of cancers is analyzed. Extending…

The surprisingly mercurial Covid-19 pandemic has highlighted the need to not only accelerate research on infectious disease, but to also study them using novel techniques and perspectives. A major contributor to the difficulty of containing…

Populations and Evolution · Quantitative Biology 2022-07-21 Aminur Rahman , Angela Peace , Ramesh Kesawan , Souparno Ghosh

Extreme precipitation shows non-stationary behavior over time, but also with respect to other large-scale variables. While this effect is often neglected, we propose a model including the influence of North Atlantic Oscillation, time,…

Atmospheric and Oceanic Physics · Physics 2022-11-09 Felix S. Fauer , Henning W. Rust

Advances in Geographical Information Systems (GIS) have led to the enormous recent burgeoning of spatial-temporal databases and associated statistical modeling. Here we depart from the rather rich literature in space-time modeling by…

Applications · Statistics 2013-04-17 Harrison Quick , Sudipto Banerjee , Bradley P. Carlin

Infectious disease models can be of great use for understanding the underlying mechanisms that influence the spread of diseases and predicting future disease progression. Modeling has been increasingly used to evaluate the potential impact…

Applications · Statistics 2019-08-20 Md Mahsin , Rob Deardon , Patrick Brown

Accurate estimates of the under-5 mortality rate (U5MR) in a developing world context are a key barometer of the health of a nation. This paper describes new models to analyze survey data on mortality in this context. We are interested in…

When surveillance data of infectious disease incidence (e.g. weekly case counts) are disaggregated by demographic indicators, disparities in long-run health outcomes between these groups become apparent. Accurate identification of high-risk…

Methodology · Statistics 2026-05-29 Miles Moran , Rob Trangucci , Lisa Madsen

Spatiotemporal modelling of infectious diseases such as COVID-19 involves using a variety of epidemiological metrics such as regional proportion of cases or regional positivity rates. Although observing their changes over time is critical…

A common goal in modeling demographic rates is to compare two or more groups. For ex- ample comparing mortality rates between men and women or between geographic regions may reveal health inequalities. A popular class of models for…

Methodology · Statistics 2018-06-08 Theresa Smith

In public health applications, spatial data collected are often recorded at different spatial scales and over different correlated variables. Spatial change of support is a key inferential problem in these applications and have become…

Methodology · Statistics 2024-03-28 Shijie Zhou , Jonathan R. Bradley

Smoking is one of the main risk factors that has affected human mortality and life expectancy over the past century. Smoking accounts for a large part of the nonlinearities in the growth of life expectancy and of the geographic and sex…

Applications · Statistics 2019-10-29 Yicheng Li , Adrian E. Raftery

This paper proposes a novel data-driven approach for identifying and modelling areas with similar temperature variations throufigureh clustering and Space-Time AutoRegressive (STAR) models. Using annual temperature data from 168 countries…

Applications · Statistics 2026-01-30 Edoardo Otranto

In environmental science applications, extreme events frequently exhibit a complex spatio-temporal structure, which is difficult to describe flexibly and estimate in a computationally efficient way using state-of-art parametric…

Methodology · Statistics 2022-12-22 Marco Oesting , Raphaël Huser

Accurate forecasts of weekly mortality are essential for public health and the insurance industry. We develop a forecasting framework that extends the Lee-Carter model with age- and region-specific seasonal effects and penalized distributed…

Applications · Statistics 2026-05-22 Jens Robben , Karim Barigou

Joinpoint regression is used to determine the number of segments needed to adequately explain the relationship between two variables. This methodology can be widely applied to real problems, but we focus on epidemiological data, the main…

Applications · Statistics 2011-12-08 Miguel A. Martinez-Beneito , Gonzalo García-Donato , Diego Salmerón
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