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Molecular-scale computation is crucial for smart materials and nanoscale devices, yet creating single-molecule systems capable of complex computations remains challenging. We present a theoretical framework for a single-molecule computer…

Statistical Mechanics · Physics 2024-10-01 Zhongmin Zhang , Zhiyue Lu

Powerful yet complex deep neural networks (DNNs) have fueled a booming demand for efficient DNN solutions to bring DNN-powered intelligence into numerous applications. Jointly optimizing the networks and their accelerators are promising in…

Machine Learning · Computer Science 2025-01-07 Yongan Zhang , Yonggan Fu , Weiwen Jiang , Chaojian Li , Haoran You , Meng Li , Vikas Chandra , Yingyan Celine Lin

NP-complete problems are widely and deeply involved in various real-life scenarios while still intractable to solve efficiently on conventional computers. It is of great practical significance to construct versatile computing architectures…

Optics · Physics 2023-08-29 Xiao-Yun Xu , Tian-Yu Zhang , Zi-Wei Wang , Chu-Han Wang , Xian-Min Jin

Analysis of DNA samples is an important step in forensics, and the speed of analysis can impact investigations. Comparison of DNA sequences is based on the analysis of short tandem repeats (STRs), which are short DNA sequences of 2-5 base…

Performance · Computer Science 2018-03-07 Siddharth Samsi , Brian Helfer , Jeremy Kepner , Albert Reuther , Darrell O. Ricke

The focus of my PhD thesis is on exploring parallel approaches to efficiently solve problems modeled by constraints and presenting a new proposal. Current solvers are very advanced; they are carefully designed to effectively manage the…

Artificial Intelligence · Computer Science 2019-09-23 Fabio Tardivo

Semiparametric statistics play a pivotal role in a wide range of domains, including but not limited to missing data, causal inference, and transfer learning, to name a few. In many settings, semiparametric theory leads to (nearly)…

Machine Learning · Statistics 2024-08-06 Qinshuo Liu , Zixin Wang , Xi-An Li , Xinyao Ji , Lei Zhang , Lin Liu , Zhonghua Liu

The early promises of DNA computing to deliver a massively parallel architecture well-suited to computationally hard problems have so far been largely unkept. Indeed, it is probably fair to say that only toy problems have been addressed…

Cryptography and Security · Computer Science 2007-05-23 Olivier Pelletier , Andre Weimerskirch

It is well known, and appreciated, that quantum computers have the potential to be the most powerful computational devices ever created. This newfound power comes from a quantum parallelism effect that allows the computer to be in multiple…

Quantum Physics · Physics 2007-05-23 Mark A Bashuk

We present an original model of paraconsistent Turing machines (PTMs), a generalization of the classical Turing machines model of computation using a paraconsistent logic. Next, we briefl y describe the standard models of quantum…

Quantum Physics · Physics 2007-05-23 Juan C. Agudelo , Walter Carnielli

Improving the throughput of molecular docking, a computationally intensive phase of the virtual screening process, is a highly sought area of research since it has a significant weight in the drug designing process. With such improvements,…

Artificial Intelligence · Computer Science 2013-12-05 Upul Senanayake , Rahal Prabuddha , Roshan Ragel

Many real-life problems of practical importance -- spanning a wide range of applications from chip design to bioinformatics -- represent constraint satisfaction problems, where classical solvers have to rely on heuristic approximations due…

Emerging Technologies · Computer Science 2026-03-03 Recep Bugra Uludag , Ahmet Efe , Ismail Akturk , Ulya R Karpuzcu

The number of cores on graphical computing units (GPUs) is reaching thousands nowadays, whereas the clock speed of processors stagnates. Unfortunately, constraint programming solvers do not take advantage yet of GPU parallelism. One reason…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-07-26 Pierre Talbot , Frédéric Pinel , Pascal Bouvry

We study the problem of computing a full Conjunctive Query in parallel using $p$ heterogeneous machines. Our computational model is similar to the MPC model, but each machine has its own cost function mapping from the number of bits it…

Databases · Computer Science 2025-03-12 Simon Frisk , Paraschos Koutris

In a spiking neural network (SNN), individual neurons operate autonomously and only communicate with other neurons sparingly and asynchronously via spike signals. These characteristics render a massively parallel hardware implementation of…

Machine Learning · Computer Science 2017-05-17 Ping Tak Peter Tang , Tsung-Han Lin , Mike Davies

Massively parallel hardware (GPUs) and long sequence data have made parallel algorithms essential for machine learning at scale. Yet dynamical systems, like recurrent neural networks and Markov chain Monte Carlo, were thought to suffer from…

Numerical Analysis · Mathematics 2026-03-18 Xavier Gonzalez

Motivation: With the development of droplet based systems, massive single cell transcriptome data has become available, which enables analysis of cellular and molecular processes at single cell resolution and is instrumental to…

Machine Learning · Computer Science 2018-12-27 Tiehang Duan , José P. Pinto , Xiaohui Xie

Inspired by recent successes with parallel optimization techniques for solving Boolean satisfiability, we investigate a set of strategies and heuristics that aim to leverage parallel computing to improve the scalability of neural network…

Logic in Computer Science · Computer Science 2020-08-24 Haoze Wu , Alex Ozdemir , Aleksandar Zeljić , Ahmed Irfan , Kyle Julian , Divya Gopinath , Sadjad Fouladi , Guy Katz , Corina Pasareanu , Clark Barrett

Probabilistic computers built from p-bits offer a promising path for combinatorial optimization, but the dense connectivity required by real-world problems scales poorly in hardware. Here, we address this through graph sparsification with…

Tensor operations dominate modern computational workloads, yet their further acceleration demands hardware platforms with greater parallelism. Although photonic computing provides a compelling route for parallel processing, fully exploiting…

Parallel Quantum Annealing is a technique to solve multiple optimization problems simultaneously. Parallel quantum annealing aims to optimize the utilization of available qubits on a quantum topology by addressing multiple independent…

Quantum Physics · Physics 2024-03-12 Arit Kumar Bishwas , Anuraj Som , Saurabh Choudhary
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