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Structural equation modeling (SEM) and path analysis have long been central tools for studying complex causal relationships in the social and behavioral sciences, yet their reliance on parametric assumptions can lead to biased inference…

Other Statistics · Statistics 2026-03-10 Junjie Ma , Xiaoya Zhang , Guangye He , Yuting Han , Ting Ge , Feng Ji

Understanding the effects of quarantine policies in populations with underlying social networks is crucial for public health, yet most causal inference methods fail here due to their assumption of independent individuals. We introduce…

Artificial Intelligence · Computer Science 2024-12-09 Suhan Guo , Furao Shen , Ni Li

We study targeted maximum likelihood estimation (TMLE) of the average treatment effect in a semiparametric regression model whose mean function is indexed by a finite-dimensional parameter, while the additive error distribution is left…

Methodology · Statistics 2026-04-20 Mijeong Kim

With deep learning's success, a limited number of popular deep nets have been widely adopted for various vision tasks. However, this usually results in unnecessarily high complexities and possibly many features of low task utility. In this…

Computer Vision and Pattern Recognition · Computer Science 2020-12-29 Qing Tian , Tal Arbel , James J. Clark

Topological Data Analysis (TDA) has emerged as a powerful tool for extracting meaningful features from complex data structures, driving significant advancements in fields such as neuroscience, biology, machine learning, and financial…

Machine Learning · Computer Science 2025-04-02 ZiXin Lin , Nur Fariha Syaqina Zulkepli

Targeted maximum likelihood estimation (TMLE) is a general method for estimating parameters in semiparametric and nonparametric models. Each iteration of TMLE involves fitting a parametric submodel that targets the parameter of interest. We…

Methodology · Statistics 2014-06-03 Iván Díaz , Michael Rosenblum

Unlike the commonly used parametric regression models such as mixed models, that can easily violate the required statistical assumptions and result in invalid statistical inference, target maximum likelihood estimation allows more realistic…

Applications · Statistics 2020-06-17 Chi Zhang , Jennifer Ahern , Mark J. van der Laan

How can we design neural networks that allow for stable universal approximation of maps between topologically interesting manifolds? The answer is with a coordinate projection. Neural networks based on topological data analysis (TDA) use…

Machine Learning · Computer Science 2022-10-04 Michael Puthawala , Matti Lassas , Ivan Dokmanic , Pekka Pankka , Maarten de Hoop

This paper studies the generalization of the targeted minimum loss-based estimation (TMLE) framework to estimation of effects of time-varying interventions in settings where both interventions, covariates, and outcome can happen at…

Statistics Theory · Mathematics 2021-05-06 Helene C. Rytgaard , Thomas A. Gerds , Mark J. van der Laan

Object recognition is a key enabler across industry and defense. As technology changes, algorithms must keep pace with new requirements and data. New modalities and higher resolution sensors should allow for increased algorithm robustness.…

Computer Vision and Pattern Recognition · Computer Science 2020-12-24 Samuel Rivera , Joel Klipfel , Deborah Weeks

Robust decision making involves making decisions in the presence of uncertainty and is often used in critical domains such as healthcare, supply chains, and finance. Causality plays a crucial role in decision-making as it predicts the…

Methodology · Statistics 2025-07-23 Saideep Nannapaneni , Joseph Sakaya , Kyle Caron , Pedro HM Albuquerque , Zaid Tashman

Estimating causal treatment effects in observational settings is frequently compromised by selection bias arising from unobserved confounders. While traditional econometric methods struggle when these confounders are orthogonal to…

Artificial Intelligence · Computer Science 2026-01-06 Ahmed Dawoud , Osama El-Shamy

Auxiliary information can be exploited in machine learning models using the paradigm of evidence based conditional inference. Multi-modal techniques in Deep Neural Networks (DNNs) can be seen as perturbing the latent feature representation…

Computer Vision and Pattern Recognition · Computer Science 2019-12-09 Dinesh Khandelwal , Suyash Agrawal , Parag Singla , Chetan Arora

Causal mediation analysis with random interventions has become an area of significant interest for understanding time-varying effects with longitudinal and survival outcomes. To tackle causal and statistical challenges due to the complex…

Methodology · Statistics 2023-04-12 Zeyi Wang , Lars van der Laan , Maya Petersen , Thomas Gerds , Kajsa Kvist , Mark van der Laan

Recently, deep neural networks have expanded the state-of-art in various scientific fields and provided solutions to long standing problems across multiple application domains. Nevertheless, they also suffer from weaknesses since their…

Machine Learning · Computer Science 2023-05-03 Felipe Kenji Nakano , Konstantinos Pliakos , Celine Vens

Revealing the underlying causal mechanisms in the real world is crucial for scientific and technological progress. Despite notable advances in recent decades, the lack of high-quality data and the reliance of traditional causal discovery…

Machine Learning · Computer Science 2026-02-17 Huaming Du , Tao Hu , Yijie Huang , Yu Zhao , Guisong Liu , Tao Gu , Gang Kou , Carl Yang

We often seek to estimate the impact of an exposure naturally occurring or randomly assigned at the cluster-level. For example, the literature on neighborhood determinants of health continues to grow. Likewise, community randomized trials…

Methodology · Statistics 2021-07-08 Laura B. Balzer , Wenjing Zheng , Mark J. van der Laan , Maya L. Petersen

Recent years have seen rapid progress at the intersection between causality and machine learning. Motivated by scientific applications involving high-dimensional data, in particular in biomedicine, we propose a deep neural architecture for…

Machine Learning · Computer Science 2022-12-12 Kai Lagemann , Christian Lagemann , Bernd Taschler , Sach Mukherjee

Training data attribution (TDA) techniques find influential training data for the model's prediction on the test data of interest. They approximate the impact of down- or up-weighting a particular training sample. While conceptually useful,…

Machine Learning · Computer Science 2023-11-01 Elisa Nguyen , Minjoon Seo , Seong Joon Oh

We revisit Deep Linear Discriminant Analysis (Deep LDA) from a likelihood-based perspective. While classical LDA is a simple Gaussian model with linear decision boundaries, attaching an LDA head to a neural encoder raises the question of…

Machine Learning · Statistics 2026-02-23 Maxat Tezekbayev , Arman Bolatov , Zhenisbek Assylbekov
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