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We present a model of the evolution of control systems in a genome under environmental constraints. The model conceptually follows the Jacob and Monod model of gene control. Genes contain control elements which respond to the internal state…

Genomics · Quantitative Biology 2021-06-09 William Bains , Enrico Borriello , Dirk Schulze-Makuch

All cognitive agents are composite beings. Specifically, complex living agents consist of cells, which are themselves competent sub-agents navigating physiological and metabolic spaces. Behavior science, evolutionary developmental biology,…

Populations and Evolution · Quantitative Biology 2022-11-17 Leo Pio-Lopez , Johanna Bischof , Jennifer V. LaPalme , Michael Levin

"Dynamic compensation" is a robustness property where a perturbed biological circuit maintains a suitable output [Karin O., Swisa A., Glaser B., Dor Y., Alon U. (2016). Mol. Syst. Biol., 12: 886]. In spite of several attempts, no fully…

Systems and Control · Computer Science 2018-01-17 Michel Fliess , Cédric Join

Feedback is ubiquitous in both biological and engineered control systems. In biology, in addition to typical feedback between plant and controller, we observe feedback pathways within control systems, which we call internal feedback…

Designing soft robots poses considerable challenges: automated design approaches may be particularly appealing in this field, as they promise to optimize complex multi-material machines with very little or no human intervention.…

Artificial Intelligence · Computer Science 2017-11-20 Francesco Corucci , Nick Cheney , Francesco Giorgio-Serchi , Josh Bongard , Cecilia Laschi

Instances of critical-like characteristics in living systems at each organizational level as well as the spontaneous emergence of computation (Langton), indicate the relevance of self-organized criticality (SOC). But extrapolating complex…

Other Quantitative Biology · Quantitative Biology 2012-08-23 Gargi Mitra-Delmotte , A. N. Mitra

The unprecedented prowess of measurement techniques provides a detailed, multi-scale look into the depths of living systems. Understanding these avalanches of high-dimensional data -- by distilling underlying principles and mechanisms --…

Other Quantitative Biology · Quantitative Biology 2021-08-16 Jean-Pierre Eckmann , Tsvi Tlusty

In this paper we consider a microscopic model of a simple ecosystem. The basic ingredients of this model are individuals, and both the phenotypic and genotypic levels are taken in account. The model is based on a long range cellular…

Statistical Mechanics · Physics 2007-05-23 Franco Bagnoli , Michele Bezzi

The complexity of a legged robot's environment or task can inform how specialised its gait must be to ensure success. Evolving specialised robotic gaits demands many evaluations - acceptable for computer simulations, but not for physical…

Robotics · Computer Science 2019-02-13 Tønnes Frostad Nygaard , Charles Patrick Martin , Jim Torresen , Kyrre Glette

Gene expression is a central process to any form of life. It involves multiple temporal and functional scales that extend from specific protein-DNA interactions to the coordinated regulation of multiple genes in response to intracellular…

Molecular Networks · Quantitative Biology 2013-07-11 Jose M. G. Vilar , Leonor Saiz

Phenotypes of individuals in a population of organisms are not fixed. Phenotypic fluctuations, which describe temporal variation of the phenotype of an individual or individual-to-individual variation across a population, are present in…

Populations and Evolution · Quantitative Biology 2018-08-15 Hong-Yan Shih , Harry Mickalide , David T. Fraebel , Nigel Goldenfeld , Seppe Kuehn

Robots operating in the real world will experience a range of different environments and tasks. It is essential for the robot to have the ability to adapt to its surroundings to work efficiently in changing conditions. Evolutionary robotics…

Robotics · Computer Science 2020-10-21 Tønnes F. Nygaard , Charles P. Martin , David Howard , Jim Torresen , Kyrre Glette

We propose a hybrid dynamical system approach to model the evolution of a pathogen that experiences different selective pressures according to a stochastic process. In every environment, the evolution of the pathogen is described by a…

Classical Analysis and ODEs · Mathematics 2019-03-25 Jozsef Z. Farkas , Peter Hinow , Jan Engelstädter

Soft robotics is a rapidly growing area of robotics research that would benefit greatly from design automation, given the challenges of manually engineering complex, compliant, and generally non-intuitive robot body plans and behaviors. It…

Robotics · Computer Science 2023-06-19 Alican Mertan , Nick Cheney

The mutual influence of dynamics and structure is a central issue in complex systems. In this paper we study by simulation slow evolution of network under the feedback of a local-majority-rule opinion process. If performance-enhancing local…

Physics and Society · Physics 2009-11-13 Zhen Shao , Haijun Zhou

Control systems should enforce a desired property for both expected modeled situations as well as unexpected unmodeled environmental situations. Existing methods focus on designing controllers to enforce the desired property only when the…

Systems and Control · Electrical Eng. & Systems 2021-10-19 Rômulo Meira-Góes , Eunsuk Kang , Stéphane Lafortune , Stavros Tripakis

A number of factors, such as, cell-cell interactions and self-propulsion of cells driven by cytoskeletal forces determine tissue morphologies and dynamics. To explore the interplay between these factors in controlling the dynamics at the…

Soft Condensed Matter · Physics 2025-05-12 Rajsekhar Das , Xin Li , Sumit Sinha , D. Thirumalai

Bacteria live in environments that are continuously fluctuating and changing. Exploiting any predictability of such fluctuations can lead to an increased fitness. On longer timescales bacteria can "learn" the structure of these fluctuations…

Cell Behavior · Quantitative Biology 2021-01-05 Stefan Landmann , Caroline M. Holmes , Mikhail Tikhonov

Gene regulatory dynamics is governed by molecular processes and therefore exhibits an inherent stochasticity. However, for the survival of an organism it is a strict necessity that this intrinsic noise does not prevent robust functioning of…

Molecular Networks · Quantitative Biology 2007-05-23 Stefan Braunewell , Stefan Bornholdt

Cells maintain a stable size as they grow and divide. Inspired by the available experimental data, most proposed models for size homeostasis assume size control mechanisms that act on a timescale of one generation. Such mechanisms lead to…

Biological Physics · Physics 2023-05-25 Motasem ElGamel , Harsh Vashistha , Hanna Salman , Andrew Mugler