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We demonstrate the first-ever nontrivial, biologically realistic connectome simulated on neuromorphic computing hardware. Specifically, we implement the whole-brain connectome of the adult Drosophila melanogaster (fruit fly) from the…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-08-26 Felix Wang , Bradley H. Theilman , Fred Rothganger , William Severa , Craig M. Vineyard , James B. Aimone

Despite the progress in deep learning networks, efficient learning at the edge (enabling adaptable, low-complexity machine learning solutions) remains a critical need for defense and commercial applications. We envision a pipeline to…

Since their inception, artificial neural networks have relied on manually designed architectures and inductive biases to better adapt to data and tasks. With the rise of deep learning and the expansion of parameter spaces, they have begun…

Neural and Evolutionary Computing · Computer Science 2026-01-28 Weifeng Liu

We aimed to explore the capability of deep learning to approximate the function instantiated by biological neural circuits-the functional connectome. Using deep neural networks, we performed supervised learning with firing rate observations…

Neurons and Cognition · Quantitative Biology 2022-11-24 Sihao Liu , Augustine N Mavor-Parker , Caswell Barry

The field of artificial intelligence faces significant challenges in achieving both biological plausibility and computational efficiency, particularly in visual learning tasks. Current artificial neural networks, such as convolutional…

Machine Learning · Computer Science 2024-09-27 Jacobo Ruiz , Manas Gupta

Mapping the connectivity of neurons in the brain (i.e., connectomics) is a challenging problem due to both the number of connections in even the smallest organisms and the nanometer resolution required to resolve them. Because of this,…

Neurons and Cognition · Quantitative Biology 2014-09-08 Ting Zhao , Stephen M Plaza

Grand efforts in neuroscience are working toward mapping the connectomes of many new species, including the near completion of the Drosophila melanogaster. It is important to ask whether these models could benefit artificial intelligence.…

Neural and Evolutionary Computing · Computer Science 2022-12-26 Samuel Schmidgall , Catherine Schuman , Maryam Parsa

Whole-brain biological neural networks naturally support the learning and control of whole-body movements. However, the use of brain connectomes as neural network controllers in embodied reinforcement learning remains unexplored. We…

Machine Learning · Computer Science 2026-03-10 Zehao Jin , Yaoye Zhu , Chen Zhang , Yanan Sui

Edge AI applications increasingly require models that can learn and adapt on-device with minimal energy budget. Traditional deep learning models, while powerful, are often overparameterized, energy-hungry, and dependent on cloud…

Hardware Architecture · Computer Science 2025-06-24 Muhammad Ihsan Al Hafiz , Naresh Ravichandran , Anders Lansner , Pawel Herman , Artur Podobas

Training deep neural networks with the error backpropagation algorithm is considered implausible from a biological perspective. Numerous recent publications suggest elaborate models for biologically plausible variants of deep learning,…

Neural and Evolutionary Computing · Computer Science 2019-07-16 Bernd Illing , Wulfram Gerstner , Johanni Brea

Bees display the remarkable ability to return home in a straight line after meandering excursions to their environment. Neurobiological imaging studies have revealed that this capability emerges from a path integration mechanism implemented…

Our brain consists of biological neurons encoding information through accurate spike timing, yet both the architecture and learning rules of our brain remain largely unknown. Comparing to the recent development of backpropagation-based…

Neural and Evolutionary Computing · Computer Science 2021-11-29 Yukun Yang , Peng Li

To understand the learning process in brains, biologically plausible algorithms have been explored by modeling the detailed neuron properties and dynamics. On the other hand, simplified multi-layer models of neural networks have shown great…

Neural and Evolutionary Computing · Computer Science 2019-09-06 Yuan Zeng , Zubayer Ibne Ferdous , Weixiang Zhang , Mufan Xu , Anlan Yu , Drew Patel , Xiaochen Guo , Yevgeny Berdichevsky , Zhiyuan Yan

Deep networks are now able to achieve human-level performance on a broad spectrum of recognition tasks. Independently, neuromorphic computing has now demonstrated unprecedented energy-efficiency through a new chip architecture based on…

Decoding the heterogeneity of biological neural systems is key to understanding the nervous system's complex dynamical behaviors. This study analyzes the comprehensive Drosophila brain connectome, which is the most recent data set,…

Neurons and Cognition · Quantitative Biology 2025-10-01 Xiaoyu Zhang , Pengcheng Yang , Yifei Zhang , Bowei Qin , Qiang Luo , Wei Lin , Xin Lu

Cerebellar-like networks, in which input activity patterns are separated by projection to a much higher-dimensional space before classification, are a recurring neurobiological motif, present in the cerebellum, dentate gyrus, insect…

Neurons and Cognition · Quantitative Biology 2026-03-23 William Dorrell , Peter E. Latham

Accurately predicting individual neurons' responses and spatial functional properties in complex visual tasks remains a key challenge in understanding neural computation. Existing whole-brain connectome models of Drosophila often rely on…

Neurons and Cognition · Quantitative Biology 2025-12-09 Jiangping Xie , Ruohan Ren , Xiao Zhou , Ao Zheng , Jiasong Zhu , Wenyu Jiang , Ziran Zhao

How intelligence emerges from living beings has been a fundamental question in neuroscience. However, it remains largely unanswered due to the complex neuronal dynamics and intricate connections between neurons in real neural systems. To…

Neurons and Cognition · Quantitative Biology 2024-09-04 Xiaoyu Zhang , Pengcheng Yang , Jiawei Feng , Qiang Luo , Wei Lin , Xin Lu

Binarized neural networks (BNNs) are gaining interest in the deep learning community due to their significantly lower computational and memory cost. They are particularly well suited to reconfigurable logic devices, which contain an…

Computer Vision and Pattern Recognition · Computer Science 2017-01-30 Nicholas J. Fraser , Yaman Umuroglu , Giulio Gambardella , Michaela Blott , Philip Leong , Magnus Jahre , Kees Vissers

The rapidly growing computational demands of deep neural networks require novel hardware designs. Recently, tunable nanoelectronic devices were developed based on hopping electrons through a network of dopant atoms in silicon. These "Dopant…

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