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Consider the case that we observe $n$ independent and identically distributed copies of a random variable with a probability distribution known to be an element of a specified statistical model. We are interested in estimating an infinite…

Statistics Theory · Mathematics 2017-09-20 Mark J. van der Laan , Aurélien F. Bibaut

The Highly-Adaptive-Lasso(HAL)-TMLE is an efficient estimator of a pathwise differentiable parameter in a statistical model that at minimal (and possibly only) assumes that the sectional variation norm of the true nuisance parameters are…

Statistics Theory · Mathematics 2017-09-01 Mark van der Laan

We consider estimation of a functional parameter of a realistically modeled data distribution based on observing independent and identically distributed observations. We define an $m$-th order Spline Highly Adaptive Lasso Minimum Loss…

Statistics Theory · Mathematics 2021-07-05 Mark J. van der Laan , David Benkeser , Weixin Cai

The Highly-Adaptive-LASSO Targeted Minimum Loss Estimator (HAL-TMLE) is an efficient plug-in estimator of a pathwise differentiable parameter in a statistical model that at minimal (and possibly only) assumes that the sectional variation…

Statistics Theory · Mathematics 2020-02-12 Weixin Cai , Mark van der Laan

We consider estimation of conditional hazard functions and densities over the class of multivariate c\`adl\`ag functions with uniformly bounded sectional variation norm when data are either fully observed or subject to right-censoring. We…

Statistics Theory · Mathematics 2024-04-18 Anders Munch , Thomas A. Gerds , Mark J. van der Laan , Helene C. W. Rytgaard

We address the challenge of performing Targeted Maximum Likelihood Estimation (TMLE) after an initial Highly Adaptive Lasso (HAL) fit. Existing approaches that utilize the data-adaptive working model selected by HAL-such as the relaxed HAL…

Methodology · Statistics 2025-06-23 Yi Li , Sky Qiu , Zeyi Wang , Mark van der Laan

We consider estimation of a functional of the data distribution based on i.i.d. observations. We assume the target function can be defined as the minimizer of the expectation of a loss function over a class of $d$-variate real valued cadlag…

Statistics Theory · Mathematics 2023-02-01 Mark van der Laan

In this paper, we propose a new method for estimation and constructing confidence intervals for low-dimensional components in a high-dimensional model. The proposed estimator, called Constrained Lasso (CLasso) estimator, is obtained by…

Methodology · Statistics 2017-04-19 Yun Yang

Constructing confidence intervals for the coefficients of high-dimensional sparse linear models remains a challenge, mainly because of the complicated limiting distributions of the widely used estimators, such as the lasso. Several methods…

Methodology · Statistics 2020-03-17 Hanzhong Liu , Xin Xu , Jingyi Jessica Li

We introduce the Meta Highly-Adaptive-Lasso Minimum Loss Estimator (M-HAL-MLE), a novel ensemble approach for estimating functional parameters of realistically modeled data distribution from independent and identically distributed…

Methodology · Statistics 2025-07-28 Zeyi Wang , Wenxin Zhang , Brian S Caffo , Martin Lindquist , Mark van der Laan

The Highly Adaptive Lasso (HAL) is a nonparametric regression method that achieves almost dimension-free convergence rates under minimal smoothness assumptions, but its implementation can be computationally prohibitive in high dimensions…

Machine Learning · Statistics 2026-05-06 Mingxun Wang , Alejandro Schuler , Mark van der Laan , Carlos García Meixide

Confidence sets play a fundamental role in statistical inference. In this paper, we consider confidence intervals for high dimensional linear regression with random design. We first establish the convergence rates of the minimax expected…

Statistics Theory · Mathematics 2015-11-30 T. Tony Cai , Zijian Guo

We develop adaptive estimation and inference methods for high-dimensional Gaussian copula regression that achieve the same performance without the knowledge of the marginal transformations as that for high-dimensional linear regression.…

Methodology · Statistics 2015-12-09 T. Tony Cai , Linjun Zhang

Vector autoregression (VAR) is a fundamental tool for modeling multivariate time series. However, as the number of component series is increased, the VAR model becomes overparameterized. Several authors have addressed this issue by…

Methodology · Statistics 2020-09-09 William B. Nicholson , Ines Wilms , Jacob Bien , David S. Matteson

The purpose of this paper is to propose methodologies for statistical inference of low-dimensional parameters with high-dimensional data. We focus on constructing confidence intervals for individual coefficients and linear combinations of…

Methodology · Statistics 2012-11-05 Cun-Hui Zhang , Stephanie S. Zhang

We propose a novel, fully nonparametric approach for the multi-task learning, the Multi-task Highly Adaptive Lasso (MT-HAL). MT-HAL simultaneously learns features, samples and task associations important for the common model, while imposing…

Beta regression is commonly employed when the outcome variable is a proportion. Since its conception, the approach has been widely used in applications spanning various scientific fields. A series of extensions have been proposed over time,…

Methodology · Statistics 2025-07-29 Niloofar Ramezani , Martin Slawski

We address functional uncertainty quantification for ill-posed inverse problems where it is possible to evaluate a possibly rank-deficient forward model, the observation noise distribution is known, and there are known parameter…

Methodology · Statistics 2025-02-06 Michael Stanley , Pau Batlle , Pratik Patil , Houman Owhadi , Mikael Kuusela

Investigators often use the data to generate interesting hypotheses and then perform inference for the generated hypotheses. P-values and confidence intervals must account for this explorative data analysis. A fruitful method for doing so…

Methodology · Statistics 2018-02-06 Keli Liu , Jelena Markovic , Robert Tibshirani

A great deal of interest has recently focused on conducting inference on the parameters in a high-dimensional linear model. In this paper, we consider a simple and very na\"{i}ve two-step procedure for this task, in which we (i) fit a lasso…

Methodology · Statistics 2020-07-02 Sen Zhao , Daniela Witten , Ali Shojaie
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