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Large foundation models, including large language models (LLMs), vision transformers (ViTs), diffusion, and LLM-based multimodal models, are revolutionizing the entire machine learning lifecycle, from training to deployment. However, the…

Current compiler optimization reports often present complex, technical information that is difficult for programmers to interpret and act upon effectively. This paper assesses the capability of large language models (LLM) to understand…

Programming Languages · Computer Science 2025-06-16 Peter Pirkelbauer , Chunhua Liao

Training large foundation models for agentic tasks is increasingly impractical due to the high computational costs, long iteration cycles, and rapid obsolescence as new models are continuously released. Instead of post-training massive…

Recent studies in prompting large language model (LLM) for document-level machine translation (DMT) primarily focus on the inter-sentence context by flatting the source document into a long sequence. This approach relies solely on the…

Computation and Language · Computer Science 2025-03-18 Bin Liu , Xinglin Lyu , Junhui Li , Daimeng Wei , Min Zhang , Shimin Tao , Hao Yang

The ongoing evolution of language models has led to the development of large-scale architectures that demonstrate exceptional performance across a wide range of tasks. However, these models come with significant computational and energy…

Artificial Intelligence · Computer Science 2025-11-19 Xialie Zhuang , Peixian Ma , Zhikai Jia , Zane Cao , Shiwei Liu

Large language models (LLMs) have demonstrated broad utility across molecular domains, spanning drug discovery and materials design. Analyzing LLMs' latent representations is crucial for elucidating their underlying mechanisms, improving…

Machine Learning · Computer Science 2026-02-03 Zhuoran Li , Xu Sun , Wanyu Lin , Jiannong Cao

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

Clinical trial matching is a key process in health delivery and discovery. In practice, it is plagued by overwhelming unstructured data and unscalable manual processing. In this paper, we conduct a systematic study on scaling clinical trial…

Large language models (LLMs) have recently shown remarkable performance in language tasks and beyond. However, due to their limited inherent causal reasoning ability, LLMs still face challenges in handling tasks that require robust causal…

Computation and Language · Computer Science 2025-03-13 Xin Li , Zhuo Cai , Shoujin Wang , Kun Yu , Fang Chen

When using supervised fine-tuning (SFT) to adapt large language models (LLMs) to specific domains, a significant challenge arises: should we use the entire SFT dataset for fine-tuning? Common practice often involves fine-tuning directly on…

Computation and Language · Computer Science 2025-05-26 Xiang Liu , Zhaoxiang Liu , Peng Wang , Kohou Wang , Huan Hu , Kai Wang , Shiguo Lian

Large language models (LLMs) have revolutionized the landscape of Natural Language Processing systems, but are computationally expensive. To reduce the cost without sacrificing performance, previous studies have explored various approaches…

Computation and Language · Computer Science 2024-10-01 Chia-Hsuan Lee , Hao Cheng , Mari Ostendorf

In recent years, developing compact and efficient large language models (LLMs) has emerged as a thriving area of research. Traditional Supervised Fine-Tuning (SFT), which relies on singular ground truth labels, often fails to capture…

Machine Learning · Computer Science 2025-06-12 Jingyao Li , Senqiao Yang , Sitong Wu , Han Shi , Chuanyang Zheng , Hong Xu , Jiaya Jia

This paper presents a comprehensive and practical guide for practitioners and end-users working with Large Language Models (LLMs) in their downstream natural language processing (NLP) tasks. We provide discussions and insights into the…

Computation and Language · Computer Science 2023-04-28 Jingfeng Yang , Hongye Jin , Ruixiang Tang , Xiaotian Han , Qizhang Feng , Haoming Jiang , Bing Yin , Xia Hu

In recent years, single cell RNA sequencing has become a widely used technique to study cellular diversity and function. However, accurately annotating cell types from single cell data has been a challenging task, as it requires extensive…

Genomics · Quantitative Biology 2023-04-07 Zehua Zeng , Hongwu Du

Unit testing is a fundamental practice in modern software engineering, with the aim of ensuring the correctness, maintainability, and reliability of individual software components. Very recently, with the advances in Large Language Models…

Software Engineering · Computer Science 2025-06-19 Quanjun Zhang , Chunrong Fang , Siqi Gu , Ye Shang , Zhenyu Chen , Liang Xiao

In recent years, large language models (LLMs) have achieved state-of-the-art results in various biological sequence analysis tasks, such as sequence classification, structure prediction, and function prediction. Similar to advancements in…

Genomics · Quantitative Biology 2025-02-19 Wang Liang

Data science plays a critical role in biomedical research, but it requires professionals with expertise in coding and medical data analysis. Large language models (LLMs) have shown great potential in supporting medical tasks and performing…

Artificial Intelligence · Computer Science 2025-04-10 Zifeng Wang , Benjamin Danek , Ziwei Yang , Zheng Chen , Jimeng Sun

Large Language Models (LLMs) have shown remarkable performance in various natural language processing tasks but face challenges in mathematical reasoning, where complex problem-solving requires both linguistic understanding and mathematical…

Computation and Language · Computer Science 2025-03-20 Shuguang Chen , Guang Lin

Large language models (LLMs) trained on text demonstrated remarkable results on natural language processing (NLP) tasks. These models have been adapted to decipher the language of DNA, where sequences of nucleotides act as "words" that…

The recent advancements of Small Language Models (SLMs) have opened new possibilities for efficient code generation. SLMs offer lightweight and cost-effective alternatives to Large Language Models (LLMs), making them attractive for use in…

Software Engineering · Computer Science 2026-01-21 Md Mahade Hasan , Muhammad Waseem , Kai-Kristian Kemell , Jussi Rasku , Juha Ala-Rantala , Pekka Abrahamsson
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