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Confocal Raman microscopy, a highly specific and label-free technique for the microscale study of thick samples, often presents difficulties due to weak Raman signals. Inhomogeneous samples introduce wavefront aberrations that further…

Time-resolved fluorescence imaging is a key tool in biomedical applications, as it allows to non-invasively obtain functional and structural information. However, the big amount of collected data introduces challenges in both acquisition…

Flat optics have been proposed as an attractive approach for the implementation of new imaging and sensing modalities to replace and augment refractive optics. However, chromatic aberrations impose fundamental limitations on diffractive…

There has been a lot of recent research on improving the efficiency of fine-tuning foundation models. In this paper, we propose a novel efficient fine-tuning method that allows the input image size of Segment Anything Model (SAM) to be…

Computer Vision and Pattern Recognition · Computer Science 2026-04-06 Sota Kato , Hinako Mitsuoka , Kazuhiro Hotta

Molecular fluorescence microscopy is a leading approach to super-resolution and nanoscale imaging in life and material sciences. However, super-resolution fluorescence microscopy is often bottlenecked by system-specific calibrations and…

Photoacoustic microscopy (PAM) is a promising imaging modality because it is able to reveal optical absorption contrast in high resolution on the order of a micrometer. It can be applied in an endoscopic approach by implementing PAM into a…

Medical Physics · Physics 2019-11-22 Zhendong Guo , Zhanhong Ye , Weihao Shao , Lili Jing , Sung-Liang Chen

Miniature fluorescence microscopes are a standard tool in systems biology. However, widefield miniature microscopes capture only 2D information, and modifications that enable 3D capabilities increase the size and weight and have poor…

Image and Video Processing · Electrical Eng. & Systems 2020-10-13 Kyrollos Yanny , Nick Antipa , William Liberti , Sam Dehaeck , Kristina Monakhova , Fanglin Linda Liu , Konlin Shen , Ren Ng , Laura Waller

Ptychography is an enabling coherent diffraction imaging technique for both fundamental and applied sciences. Its applications in optical microscopy, however, fall short for its low imaging throughput and limited resolution. Here, we report…

Fourier ptychographic microscopy (FPM) is a powerful computational imaging modality that achieves high space-bandwidth product imaging for biomedical samples. However, its adoption is limited by slow data acquisition due to the need for…

Optics · Physics 2025-09-09 Shi Zhao , Haowen Zhou , Changhuei Yang

We present the experimental reconstruction of sub-wavelength features from the far-field of sparse optical objects. We show that it is sufficient to know that the object is sparse, and only that, and recover 100 nm features with the…

We present a large-scale computational 3D topographic microscope that enables 6-gigapixel profilometric 3D imaging at micron-scale resolution across $>$110 cm$^2$ areas over multi-millimeter axial ranges. Our computational microscope,…

Precision photometric calibration is key to a number of astrophysical research areas such as supernova cosmology and dark energy studies. In the age of large surveys, pushing the limits of photometry is a worthy challenge, with traditional…

Instrumentation and Methods for Astrophysics · Physics 2025-09-05 Kane M. Sjoberg , Johnny Esteves , Christopher W. Stubbs

Traditional glass-based optics are typically optimized for narrow spectral bands, such as the visible (400-700nm) or shortwave infrared (1000-1800nm). While the emergence of VIS-SWIR sensors (400-1700nm) offers transformative potential,…

Image and Video Processing · Electrical Eng. & Systems 2026-05-04 Vishwanath Saragadam , Niki Nezakati , Amit Roy-Chowdhury , Vivek Boominathan

Single-pixel imaging, originally developed in light optics, facilitates fast three-dimensional sample reconstruction, as well as probing with light wavelengths undetectable by conventional multi-pixel detectors. However, the spatial…

Single-pixel imaging (SPI) using a single-pixel detector is an unconventional imaging method, which has great application prospects in many fields to realize high-performance imaging. In especial, the recent proposed catadioptric panoramic…

Optics · Physics 2024-07-30 Huan Cui , Jie Cao , Haoyu Zhang , Chang Zhou , Haifeng Yao , Yingbo Wang , Qun Hao

In recent years several methods to overcome diffraction limit in the far field microscopy have been demonstrated. Still the problem of superresolution is reliably solved only for fluorescent microscopy, giving a resolution of up to 20-30nm.…

Optics · Physics 2013-09-03 Yu. V. Miklyaev , S. A. Asselborn , K. A. Zaytsev , M. Ya. Darscht

Fourier ptychographic microscopy (FPM) is a recently developed imaging modality that uses angularly varying illumination to extend a system performance beyond the limit defined by its optical elements. The FPM technique applies a novel…

Optics · Physics 2014-05-02 Xiaoze Ou , Roarke Horstmeyer , Changhuei Yang , Guoan Zheng

High-quality panoramic images with a Field of View (FoV) of 360{\deg} are essential for contemporary panoramic computer vision tasks. However, conventional imaging systems come with sophisticated lens designs and heavy optical components.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Qi Jiang , Shaohua Gao , Yao Gao , Kailun Yang , Zhonghua Yi , Hao Shi , Lei Sun , Kaiwei Wang

Hyperspectral imaging is useful for applications ranging from medical diagnostics to agricultural crop monitoring; however, traditional scanning hyperspectral imagers are prohibitively slow and expensive for widespread adoption. Snapshot…

Image and Video Processing · Electrical Eng. & Systems 2020-09-30 Kristina Monakhova , Kyrollos Yanny , Neerja Aggarwal , Laura Waller

We demonstrate a Fourier Imaging system with centimeter field of view(FOV), and 0.0042{\deg}angular resolution at C band, for the entire 180{\deg} radiation angular range. To pursue omnidirectional Fourier imaging without aberration, a…

Optics · Physics 2018-09-07 Jinxi Huang