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Transcranial focused ultrasound (tFUS) is a therapeutic ultrasound method that focuses sound through the skull to a small region noninvasively and often under MRI guidance. CT imaging is used to estimate the acoustic properties that vary…

Image and Video Processing · Electrical Eng. & Systems 2022-10-27 Han Liu , Michelle K. Sigona , Thomas J. Manuel , Li Min Chen , Benoit M. Dawant , Charles F. Caskey

Transcranial MRI-guided focused ultrasound (TcMRgFUS) is a therapeutic ultrasound method that focuses sound through the skull to a small region noninvasively under MRI guidance. It is clinically approved to thermally ablate regions of the…

Computer Vision and Pattern Recognition · Computer Science 2022-02-23 Han Liu , Michelle K. Sigona , Thomas J. Manuel , Li Min Chen , Charles F. Caskey , Benoit M. Dawant

Background: Individual skull models of bone density and geometry are important when planning the expected transcranial ultrasound acoustic field and estimating mechanical and thermal safety in low-intensity transcranial ultrasound…

Quantifying normative pediatric cranial development and suture ossification is crucial for diagnosing and treating growth-related cephalic disorders. Computed tomography (CT) is widely used to evaluate cranial and sutural deformities;…

Computer Vision and Pattern Recognition · Computer Science 2026-01-01 Krithika Iyer , Austin Tapp , Athelia Paulli , Gabrielle Dickerson , Syed Muhammad Anwar , Natasha Lepore , Marius George Linguraru

Transcranial focused ultrasound (tFUS) is an emerging modality for non-invasive brain stimulation and therapeutic intervention, offering millimeter-scale spatial precision and the ability to target deep brain structures. However, the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Vinkle Srivastav , Juliette Puel , Jonathan Vappou , Elijah Van Houten , Paolo Cabras , Nicolas Padoy

Model-based treatment planning for transcranial ultrasound therapy typically involves mapping the acoustic properties of the skull from an x-ray computed tomography (CT) image of the head. Here, three methods for generating pseudo-CT images…

Transcranial focused ultrasound (tFUS) offers noninvasive access to deep brain circuits but remains limited by skull-induced phase aberration, acoustic impedance mismatch, and poor volumetric control of intracranial pressure fields.…

Transcranial focused ultrasound (tFUS) is an emerging form of non-surgical human neuromodulation that confers advantages over existing electro and electromagnetic technologies by providing a superior spatial resolution on the millimeter…

Neurons and Cognition · Quantitative Biology 2016-03-02 Leo Ai , Jerel K. Mueller , Andrea Grant , Yigitcan Eryaman , Wynn Legon

The generation of Synthetic Computed Tomography (sCT) images has become a pivotal methodology in modern clinical practice, particularly in the context of Radiotherapy (RT) treatment planning. The use of sCT enables the calculation of doses,…

Providing more precise tissue attenuation information, synthetic computed tomography (sCT) generated from magnetic resonance imaging (MRI) contributes to improved radiation therapy treatment planning. In our study, we employ the advanced…

Image and Video Processing · Electrical Eng. & Systems 2024-09-11 Fuxin Fan , Jingna Qiu , Yixing Huang , Andreas Maier

Transcranial ultrasound therapy uses focused acoustic energy to induce therapeutic bioeffects in the brain. Ultrasound must be transmitted through the skull, which is highly attenuating and heterogeneous, causing beam distortion, reducing…

Magnetic resonance imaging (MRI)-based synthetic computed tomography (sCT) simplifies radiation therapy treatment planning by eliminating the need for CT simulation and error-prone image registration, ultimately reducing patient radiation…

Image and Video Processing · Electrical Eng. & Systems 2023-06-01 Shaoyan Pan , Elham Abouei , Jacob Wynne , Tonghe Wang , Richard L. J. Qiu , Yuheng Li , Chih-Wei Chang , Junbo Peng , Justin Roper , Pretesh Patel , David S. Yu , Hui Mao , Xiaofeng Yang

Background: Trans-spinal FUS (tsFUS) has recently been shown promise in modulating spinal reflexes in rodents, opening new avenues for spinal cord interventions in motor control and pain management. However, anatomical differences between…

Medical Physics · Physics 2025-07-09 Koharu Isomura , Wenwei Yu , Jose Gomez-Tames

Generating synthetic CT (sCT) from MRI or CBCT plays a crucial role in enabling MRI-only and CBCT-based adaptive radiotherapy, improving treatment precision while reducing patient radiation exposure. To address this task, we adopt a fully…

Computer Vision and Pattern Recognition · Computer Science 2026-04-24 Arnela Hadzic , Simon Johannes Joham , Martin Urschler

Computed tomography (CT) is a widely used imaging modality for medical diagnosis and treatment. In electroencephalography (EEG), CT imaging is necessary for co-registering with magnetic resonance imaging (MRI) and for creating more accurate…

Medical Physics · Physics 2019-06-12 Andreas D. Lauritzen , Xenophon Papademetris , Sergei Turovets , John A. Onofrey

Fetal brain magnetic resonance imaging (MRI) offers exquisite images of the developing brain but is not suitable for second-trimester anomaly screening, for which ultrasound (US) is employed. Although expert sonographers are adept at…

Image and Video Processing · Electrical Eng. & Systems 2020-08-21 Jianbo Jiao , Ana I. L. Namburete , Aris T. Papageorghiou , J. Alison Noble

Computed tomography (CT) equivalent information is needed for attenuation correction in PET imaging and for dose planning in radiotherapy. Prior work has shown that Gaussian mixture models can be used to generate a substitute CT (s-CT)…

Applications · Statistics 2016-09-29 Anders Hildeman , David Bolin , Jonas Wallin , Adam Johansson , Tufve Nyholm , Thomas Asklund , Jun Yu

Purpose: To propose a self-supervised deep learning-based compressed sensing MRI (DL-based CS-MRI) method named "Adaptive Self-Supervised Consistency Guided Diffusion Model (ASSCGD)" to accelerate data acquisition without requiring fully…

Image and Video Processing · Electrical Eng. & Systems 2025-02-11 Mojtaba Safari , Zach Eidex , Shaoyan Pan , Richard L. J. Qiu , Xiaofeng Yang

MRI provides superior soft tissue contrast without ionizing radiation; however, the absence of electron density information limits its direct use for dose calculation. As a result, current radiotherapy workflows rely on combined MRI and CT…

Computer Vision and Pattern Recognition · Computer Science 2026-02-06 Zolnamar Dorjsembe , Hung-Yi Chen , Furen Xiao , Hsing-Kuo Pao

Deep-learning-based MR-to-CT synthesis can estimate the electron density of tissues, thereby facilitating PET attenuation correction in whole-body PET/MR imaging. However, whole-body MR-to-CT synthesis faces several challenges including the…

Image and Video Processing · Electrical Eng. & Systems 2024-11-27 Jiaxu Zheng , Zhenrong Shen , Lichi Zhang , Qun Chen
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