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Graph Retrieval-Augmented Generation (Graph RAG) effectively builds a knowledge graph (KG) to connect disparate facts across a large document corpus. However, this broad-view approach often lacks the deep structured reasoning needed for…

Computation and Language · Computer Science 2025-10-27 Jiaoyang Li , Junhao Ruan , Shengwei Tang , Saihan Chen , Kaiyan Chang , Yuan Ge , Tong Xiao , Jingbo Zhu

Many complex systems combine dense background structure with sparse contextual information. We introduce a diffusion-based framework for analyzing how sparse condition-specific layers reshape diffusion geometry in multilayer hypergraphs.…

Physics and Society · Physics 2026-05-21 Hao Ding , Sanjukta Krishnagopal

Solving tough clinical questions that require both image and text understanding is still a major challenge in healthcare AI. In this work, we propose Q-FSRU, a new model that combines Frequency Spectrum Representation and Fusion (FSRU) with…

Computer Vision and Pattern Recognition · Computer Science 2025-10-06 Rakesh Thakur , Yusra Tariq , Rakesh Chandra Joshi

Diabetic retinopathy (DR) grading from fundus images has attracted increasing interest in both academic and industrial communities. Most convolutional neural network (CNN) based algorithms treat DR grading as a classification task via…

Computer Vision and Pattern Recognition · Computer Science 2021-03-19 Yehui Yang , Fangxin Shang , Binghong Wu , Dalu Yang , Lei Wang , Yanwu Xu , Wensheng Zhang , Tianzhu Zhang

Retrieval-Augmented Generation (RAG) plays a crucial role in grounding Large Language Models by leveraging external knowledge, whereas the effectiveness is often compromised by the retrieval of contextually flawed or incomplete information.…

Artificial Intelligence · Computer Science 2025-11-13 Yaoze Zhang , Rong Wu , Pinlong Cai , Xiaoman Wang , Guohang Yan , Song Mao , Ding Wang , Botian Shi

Recent developed graph-based methods for diagnosing brain disorders using functional connectivity highly rely on predefined brain atlases, but overlook the rich information embedded within atlases and the confounding effects of site and…

Machine Learning · Computer Science 2025-10-16 Qianqian Liao , Wuque Cai , Hongze Sun , Dongze Liu , Duo Chen , Dezhong Yao , Daqing Guo

Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

Quantitative Methods · Quantitative Biology 2025-11-14 Guofeng Meng , Li Shen , Qiuyan Zhong , Wei Wang , Haizhou Zhang , Xiaozhen Wang

Recent advancements in generative models have established state-of-the-art benchmarks in the generation of molecules and novel drug candidates. Despite these successes, a significant gap persists between generative models and the…

Machine Learning · Computer Science 2024-10-10 Aditya Malusare , Vaneet Aggarwal

Extracting medical knowledge from healthcare texts enhances downstream tasks like medical knowledge graph construction and clinical decision-making. However, the construction and application of knowledge extraction models lack automation,…

Artificial Intelligence · Computer Science 2023-10-05 Hongxin Ding , Peinie Zou , Zhiyuan Wang , Junfeng Zhao , Yasha Wang , Qiang Zhou

Objective: Disease knowledge graphs are a way to connect, organize, and access disparate information about diseases with numerous benefits for artificial intelligence (AI). To create knowledge graphs, it is necessary to extract knowledge…

Machine Learning · Computer Science 2022-09-01 Yucong Lin , Keming Lu , Sheng Yu , Tianxi Cai , Marinka Zitnik

Retrieval-Augmented Generation (RAG) mitigates hallucinations in Multimodal Large Language Models (MLLMs), yet existing systems struggle with complex cross-modal reasoning. Flat vector retrieval often ignores structural dependencies, while…

Information Retrieval · Computer Science 2026-04-08 Sijun Dai , Qiang Huang , Xiaoxing You , Jun Yu

Representing and exploiting multivariate signals requires capturing relations between variables, which we can represent by graphs. Graph dictionaries allow to describe complex relational information as a sparse sum of simpler structures,…

Machine Learning · Computer Science 2026-01-09 William Cappelletti , Pascal Frossard

Knowledge Graph-based Retrieval-Augmented Generation (KG-RAG) significantly enhances the reasoning capabilities of LargeLanguage Models by leveraging structured knowledge. However, existing KG-RAG frameworks typically operate as open-loop…

Information Retrieval · Computer Science 2025-08-14 Xujie Yuan , Shimin Di , Jielong Tang , Libin Zheng , Jian Yin

Synthesizing medical images while preserving their structural information is crucial in medical research. In such scenarios, the preservation of anatomical content becomes especially important. Although recent advances have been made by…

Image and Video Processing · Electrical Eng. & Systems 2024-11-14 Ziqi Yu , Botao Zhao , Shengjie Zhang , Xiang Chen , Jianfeng Feng , Tingying Peng , Xiao-Yong Zhang

Many supervised machine learning frameworks have been proposed for disease classification using functional magnetic resonance imaging (fMRI) data, producing important biomarkers. More recently, data pooling has flourished, making the result…

Quantitative Methods · Quantitative Biology 2022-02-24 Dushyant Sahoo , Mathilde Antoniades , Cynthia H. Y. Fu , Christos Davatzikos

Reliable Alzheimer's disease (AD) diagnosis increasingly relies on multimodal assessments combining structural Magnetic Resonance Imaging (MRI) and Electronic Health Records (EHR). However, deploying these models is bottlenecked by modality…

Computer Vision and Pattern Recognition · Computer Science 2026-03-04 Guanchen Wu , Zhe Huang , Yuzhang Xie , Runze Yan , Akul Chopra , Deqiang Qiu , Xiao Hu , Fei Wang , Carl Yang

We consider the problem of classifying a medical image dataset when we have a limited amounts of labels. This is very common yet challenging setting as labelled data is expensive, time consuming to collect and may require expert knowledge.…

Computer Vision and Pattern Recognition · Computer Science 2020-06-30 Marianne de Vriendt , Philip Sellars , Angelica I Aviles-Rivero

Sparse representation models a signal as a linear combination of a small number of dictionary atoms. As a generative model, it requires the dictionary to be highly redundant in order to ensure both a stable high sparsity level and a low…

Computer Vision and Pattern Recognition · Computer Science 2015-06-23 Xiaoxia Sun , Nasser M. Nasrabadi , Trac D. Tran

Computational text phenotyping is the practice of identifying patients with certain disorders and traits from clinical notes. Rare diseases are challenging to be identified due to few cases available for machine learning and the need for…

We consider a method to jointly estimate sparse precision matrices and their underlying graph structures using dependent high-dimensional datasets. We present a penalized maximum likelihood estimator which encourages both sparsity and…

Applications · Statistics 2016-08-22 Adria Caballe , Natalia Bochkina , Claus Mayer