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Unsupervised anomaly-based intrusion detection requires models that can generalize to attack patterns not observed during training. This work presents the first large-scale evaluation of hybrid quantum-classical (HQC) autoencoders for this…

Machine Learning · Computer Science 2026-04-03 Mohammad Arif Rasyidi , Omar Alhussein , Sami Muhaidat , Ernesto Damiani

Controllable generative models have been widely used to improve the realism of synthetic visual content. However, such models must handle control conditions and content generation computational requirements, resulting in generally low…

Computer Vision and Pattern Recognition · Computer Science 2025-11-17 Lin Liu , Huixia Ben , Shuo Wang , Jinda Lu , Junxiang Qiu , Shengeng Tang , Yanbin Hao

A critical challenge in single-cell RNA sequencing (scRNA-seq) integration is resolving the tension between eliminating batch effects and maintaining biological fidelity. While recent evidence indicates that batch effects manifest…

Machine Learning · Computer Science 2026-05-19 Xichen Yan , Zelin Zang , Changxi Chi , Jingbo Zhou , Chang Yu , Jinlin Wu , Shenghui Cheng , Fuji Yang , Jiebo Luo , Zhen Lei , Stan Z. Li

Cell clustering is crucial for uncovering cellular heterogeneity in single-cell RNA sequencing (scRNA-seq) data by identifying cell types and marker genes. Despite its importance, benchmarks for scRNA-seq clustering methods remain…

Genomics · Quantitative Biology 2025-12-03 Ping Xu , Zaitian Wang , Zhirui Wang , Pengjiang Li , Jiajia Wang , Ran Zhang , Pengfei Wang , Yuanchun Zhou

Variational quantum circuits (VQCs) built upon noisy intermediate-scale quantum (NISQ) hardware, in conjunction with classical processing, constitute a promising architecture for quantum simulations, classical optimization, and machine…

Quantum Physics · Physics 2021-06-09 Yi Xia , Wei Li , Quntao Zhuang , Zheshen Zhang

This article presents the Sorting Composite Quantile Regression Neural Network (SCQRNN), an advanced quantile regression model designed to prevent quantile crossing and enhance computational efficiency. Integrating ad hoc sorting in…

Machine Learning · Computer Science 2024-06-04 Jens Decke , Arne Jenß , Bernhard Sick , Christian Gruhl

Clustering can be used to extract insights from data or to verify some of the assumptions held by the domain experts, namely data segmentation. In the literature, few methods can be applied in clustering qualitative values using the context…

Machine Learning · Computer Science 2020-07-07 Diogo Seca , João Mendes-Moreira , Tiago Mendes-Neves , Ricardo Sousa

Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the cellular level. By providing data on gene expression for each individual cell, scRNA-seq generates large datasets with thousands of…

Computational Complexity · Computer Science 2025-02-11 Md Romizul Islam , Swakkhar Shatabda

Poor data quality limits the advantageous power of Machine Learning (ML) and weakens high-performing ML software systems. Nowadays, data are more prone to the risk of poor quality due to their increasing volume and complexity. Therefore,…

Machine Learning · Computer Science 2025-02-20 Manal Rahal , Bestoun S. Ahmed , Gergely Szabados , Torgny Fornstedt , Jorgen Samuelsson

Identifying cell clusters is a critical step for single-cell transcriptomics study. Despite the numerous clustering tools developed recently, the rapid growth of scRNA-seq volumes prompts for a more (computationally) efficient clustering…

Quantitative Methods · Quantitative Biology 2023-01-11 Nana Wei , Yating Nie , Lin Liu , Xiaoqi Zheng , Hua-Jun Wu4

Automatic Perceptual Image Quality Assessment is a challenging problem that impacts billions of internet, and social media users daily. To advance research in this field, we propose a Mixture of Experts approach to train two separate…

Computer Vision and Pattern Recognition · Computer Science 2023-05-30 Avinab Saha , Sandeep Mishra , Alan C. Bovik

Image quality assessment (IQA) algorithm aims to quantify the human perception of image quality. Unfortunately, there is a performance drop when assessing the distortion images generated by generative adversarial network (GAN) with…

Computer Vision and Pattern Recognition · Computer Science 2022-04-25 Shanshan Lao , Yuan Gong , Shuwei Shi , Sidi Yang , Tianhe Wu , Jiahao Wang , Weihao Xia , Yujiu Yang

Quantum Computing (QC) offers outstanding potential for molecular characterization and drug discovery, particularly in solving complex properties like the Ground State Energy (GSE) of biomolecules. However, QC faces challenges due to…

Chemical Physics · Physics 2024-12-17 Laia Coronas Sala , Parfait Atchade-Adelemou

Machine learning algorithms underpin modern diagnostic-aiding software, which has proved valuable in clinical practice, particularly in radiology. However, inaccuracies, mainly due to the limited availability of clinical samples for…

Foundation models for protein design raise concrete biosecurity risks, yet the community lacks a simple, reproducible baseline for sequence-level hazard screening that is explicitly evaluated under homology control and runs on commodity…

Machine Learning · Computer Science 2025-12-22 Muhammad Haris Khan

The existence of doublets is a key confounder in single-cell RNA sequencing (scRNA-seq) data analysis. Computational methods have been developed for detecting doublets from scRNA-seq data. We developed an R package DoubletCollection to…

Genomics · Quantitative Biology 2021-12-01 Nan Miles Xi , Jingyi Jessica Li

One of the challenges in developing deep learning algorithms for medical image segmentation is the scarcity of annotated training data. To overcome this limitation, data augmentation and semi-supervised learning (SSL) methods have been…

Image and Video Processing · Electrical Eng. & Systems 2020-09-02 Bram Ruijsink , Esther Puyol-Anton , Ye Li , Wenja Bai , Eric Kerfoot , Reza Razavi , Andrew P. King

Single-cell transcriptomics techniques, such as scRNA-seq, attempt to characterize gene expression profiles in each cell of a heterogeneous sample individually. Due to growing amounts of data generated and the increasing complexity of the…

Genomics · Quantitative Biology 2023-05-02 Laura Puente-Santamaría , Luis del Peso

Hybrid approaches that combine data-driven learning with physics-based insight have shown promise for improving the reliability of industrial condition monitoring. This work develops a hybrid condition monitoring framework that integrates…

Machine Learning · Computer Science 2026-04-14 Maryam Ahang , Todd Charter , Masoud Jalayer , Homayoun Najjaran

Single-cell RNA sequencing (scRNA-seq) has made significant strides in unraveling the intricate cellular diversity within complex tissues. This is particularly critical in the brain, presenting a greater diversity of cell types than other…

Machine Learning · Computer Science 2023-10-05 Gyutaek Oh , Baekgyu Choi , Inkyung Jung , Jong Chul Ye
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