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The remarkable capabilities of Large Language Models (LLMs) make them increasingly compelling for adoption in real-world healthcare applications. However, the risks associated with using LLMs in medical applications have not been…

Artificial Intelligence, especially Large Language Models (LLMs), has transformed domains such as software engineering, journalism, creative writing, academia, and media (Naveed et al. 2025; arXiv:2307.06435). Diffusion models like Stable…

Computation and Language · Computer Science 2025-11-11 Trivikram Satharasi , S Sitharama Iyengar

In recent years, written language, particularly in science and education, has undergone remarkable shifts in word usage. These changes are widely attributed to the growing influence of Large Language Models (LLMs), which frequently rely on…

Computation and Language · Computer Science 2025-08-04 Bryce Anderson , Riley Galpin , Tom S. Juzek

Recent advances in generative models, including large language models (LLMs), vision language models (VLMs), and diffusion models, have accelerated the field of natural language and image processing in medicine and marked a significant…

Large Language Model (LLMs) such as ChatGPT that exhibit generative AI capabilities are facing accelerated adoption and innovation. The increased presence of Generative AI (GAI) inevitably raises concerns about the risks and safety…

Computers and Society · Computer Science 2024-07-29 Jaymari Chua , Yun Li , Shiyi Yang , Chen Wang , Lina Yao

Artificial Intelligence (AI) is revolutionizing scientific research, yet its growing integration into laboratory environments presents critical safety challenges. Large language models (LLMs) and vision language models (VLMs) now assist in…

This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Artificial Intelligence · Computer Science 2025-04-08 Zahra Atf , Seyed Amir Ahmad Safavi-Naini , Peter R. Lewis , Aref Mahjoubfar , Nariman Naderi , Thomas R. Savage , Ali Soroush

Rapid integration of large language models (LLMs) in health care is sparking global discussion about their potential to revolutionize health care quality and accessibility. At a time when improving health care quality and access remains a…

Computers and Society · Computer Science 2025-04-01 Troy Zada , Natalie Tam , Francois Barnard , Marlize Van Sittert , Venkat Bhat , Sirisha Rambhatla

With the advent of Large Language Models (LLMs), medical artificial intelligence (AI) has experienced substantial technological progress and paradigm shifts, highlighting the potential of LLMs to streamline healthcare delivery and improve…

Computation and Language · Computer Science 2024-12-10 Lei Liu , Xiaoyan Yang , Junchi Lei , Yue Shen , Jian Wang , Peng Wei , Zhixuan Chu , Zhan Qin , Kui Ren

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

Although large language models (LLMs) have been assessed for general medical knowledge using licensing exams, their ability to support clinical decision-making, such as selecting medical calculators, remains uncertain. We assessed nine…

Computation and Language · Computer Science 2025-03-25 Nicholas Wan , Qiao Jin , Joey Chan , Guangzhi Xiong , Serina Applebaum , Aidan Gilson , Reid McMurry , R. Andrew Taylor , Aidong Zhang , Qingyu Chen , Zhiyong Lu

Children increasingly have access to Large Language Models (LLMs), which may expose them to responses that are developmentally inappropriate or require age-sensitive safety, guidance, and boundaries. Existing LLM safety evaluations largely…

Computation and Language · Computer Science 2026-05-27 Samee Arif , Angana Borah , Rada Mihalcea

Background: Despite the current ubiquity of Large Language Models (LLMs) across the medical domain, there is a surprising lack of studies which address their reasoning behaviour. We emphasise the importance of understanding reasoning…

Computation and Language · Computer Science 2025-07-29 Shamus Sim , Tyrone Chen

Large Language Models (LLMs) can produce surprisingly sophisticated estimates of their own uncertainty. However, it remains unclear to what extent this expressed confidence is tied to the reasoning, knowledge, or decision making of the…

Machine Learning · Computer Science 2026-01-13 Jiawei Wang , Yanfei Zhou , Siddartha Devic , Deqing Fu

Large language models (LLMs) are entering clinical workflows as decision support tools, yet how they respond to explicit patient value statements -- the core content of shared decision-making -- remains unmeasured. We conducted a factorial…

Computers and Society · Computer Science 2026-03-03 Sanjay Basu

Large language models (LLMs) have the potential to transform medicine, but real-world clinical scenarios contain extraneous information that can hinder performance. The rise of assistive technologies like ambient dictation, which…

Computation and Language · Computer Science 2025-04-03 Krithik Vishwanath , Anton Alyakin , Daniel Alexander Alber , Jin Vivian Lee , Douglas Kondziolka , Eric Karl Oermann

Large language models (LLMs) are increasingly used to generate labels from radiology reports to enable large-scale AI evaluation. However, label noise from LLMs can introduce bias into performance estimates, especially under varying disease…

Effective communication about breast and cervical cancers remains a persistent health challenge, with significant gaps in public understanding of cancer prevention, screening, and treatment, potentially leading to delayed diagnoses and…

Computation and Language · Computer Science 2025-05-19 Agnik Saha , Victoria Churchill , Anny D. Rodriguez , Ugur Kursuncu , Muhammed Y. Idris

Large Language Models (LLMs) offer a promising approach to enhancing Explainable AI (XAI) by transforming complex machine learning outputs into easy-to-understand narratives, making model predictions more accessible to users, and helping…

Artificial Intelligence · Computer Science 2025-04-02 Ahsan Bilal , David Ebert , Beiyu Lin
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