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Machine-learned force fields (MLFFs), especially pre-trained foundation models, are transforming computational materials science by enabling ab initio-level accuracy at molecular dynamics scales. Yet their rapid rise raises a key question:…

Chemical Physics · Physics 2025-10-20 Yi Cao , Paulette Clancy

We propose a simple yet effective use of LLM-powered AI tools to improve causal estimation. In double machine learning, the accuracy of causal estimates of the effect of a treatment on an outcome in the presence of a high-dimensional…

Machine Learning · Computer Science 2025-10-14 Chris Engh , P. M. Aronow

Estimation of causal effects using machine learning methods has become an active research field in econometrics. In this paper, we study the finite sample performance of meta-learners for estimation of heterogeneous treatment effects under…

Econometrics · Economics 2022-02-01 Gabriel Okasa

Existing variance reduction techniques used in stochastic simulations for rare event analysis still require a substantial number of model evaluations to estimate small failure probabilities. In the context of complex, nonlinear finite…

Machine Learning · Computer Science 2025-08-04 Liuyun Xu , Seymour M. J. Spence

High-fidelity full-field micro-mechanical modeling of the non-linear path-dependent materials demands a substantial computational effort. Recent trends in the field incorporates data-driven Artificial Neural Networks (ANNs) as surrogate…

Materials Science · Physics 2023-11-27 Hon Lam Cheung , Petter Uvdal , Mohsen Mirkhalaf

Electronic structure methods offer in principle accurate predictions of molecular properties, however, their applicability is limited by computational costs. Empirical methods are cheaper, but come with inherent approximations and are…

Chemical Physics · Physics 2023-11-16 Moritz Thürlemann , Sereina Riniker

Recent research suggests that predictions made by machine-learning models can amplify biases present in the training data. When a model amplifies bias, it makes certain predictions at a higher rate for some groups than expected based on…

Machine Learning · Computer Science 2022-10-20 Melissa Hall , Laurens van der Maaten , Laura Gustafson , Maxwell Jones , Aaron Adcock

The increasing use of machine-learning (ML) enabled systems in critical tasks fuels the quest for novel verification and validation techniques yet grounded in accepted system assurance principles. In traditional system development,…

Machine Learning · Computer Science 2020-02-11 Taejoon Byun , Sanjai Rayadurgam

Building a sustainable burn platform in inertial confinement fusion (ICF) requires an understanding of the complex coupling of physical processes and the effects that key experimental design changes have on implosion performance. While…

The aerodynamic optimization process of cars requires multiple iterations between aerodynamicists and stylists. Response Surface Modeling and Reduced-Order Modeling are commonly used to eliminate the overhead due to Computational Fluid…

Computational Engineering, Finance, and Science · Computer Science 2022-05-26 Sam Jacob Jacob , Markus Mrosek , Carsten Othmer , Harald Köstler

Predicting compound-protein affinity is critical for accelerating drug discovery. Recent progress made by machine learning focuses on accuracy but leaves much to be desired for interpretability. Through molecular contacts underlying…

Biomolecules · Quantitative Biology 2020-01-01 Mostafa Karimi , Di Wu , Zhangyang Wang , Yang Shen

We explore the application of computer vision and machine learning (ML) techniques to predict material properties (e.g. compressive strength) based on SEM images. We show that it's possible to train ML models to predict materials…

Batched synthesis and testing of molecular designs is the key bottleneck of drug development. There has been great interest in leveraging biomolecular foundation models as surrogates to accelerate this process. In this work, we show how to…

Fatigue properties of additively manufactured (AM) materials depend on many factors such as AM processing parameter, microstructure, residual stress, surface roughness, porosities, post-treatments, etc. Their evaluation inevitably requires…

Materials Science · Physics 2023-04-25 Min Yi , Ming Xue , Peihong Cong , Yang Song , Haiyang Zhang , Lingfeng Wang , Liucheng Zhou , Yinghong Li , Wanlin Guo

Artificial intelligence (AI) has been widely applied in drug discovery with a major task as molecular property prediction. Despite booming techniques in molecular representation learning, key elements underlying molecular property…

Quantitative Methods · Quantitative Biology 2023-09-06 Jianyuan Deng , Zhibo Yang , Hehe Wang , Iwao Ojima , Dimitris Samaras , Fusheng Wang

Various deep learning (DL) methods have recently been utilized to detect software vulnerabilities. Real-world software vulnerability datasets are rare and hard to acquire, as there is no simple metric for classifying vulnerability. Such…

Software Engineering · Computer Science 2025-04-29 Seyed Shayan Daneshvar , Da Tan , Shaowei Wang , Carson Leung

Drug combination therapy is a well-established strategy for disease treatment with better effectiveness and less safety degradation. However, identifying novel drug combinations through wet-lab experiments is resource intensive due to the…

Machine Learning · Computer Science 2023-01-18 Zhihang Hu , Qinze Yu , Yucheng Guo , Taifeng Wang , Irwin King , Xin Gao , Le Song , Yu Li

Federated learning is proposed as a machine learning setting to enable distributed edge devices, such as mobile phones, to collaboratively learn a shared prediction model while keeping all the training data on device, which can not only…

Machine Learning · Computer Science 2020-03-13 Lifeng Liu , Fengda Zhang , Jun Xiao , Chao Wu

New discoveries in chemistry and materials science, with increasingly expanding volume of requisite knowledge and experimental workload, provide unique opportunities for machine learning (ML) to take critical roles in accelerating research…

Large Language Models (LLM) are increasingly trained on data generated by other LLM, either because generated text and images become part of the pre-training corpus, or because synthetized data is used as a replacement for expensive…

Machine Learning · Computer Science 2024-10-28 Yunzhen Feng , Elvis Dohmatob , Pu Yang , Francois Charton , Julia Kempe
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