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The computational efficiency of the human brain is believed to stem from the parallel information processing capability of neurons with integrated storage in synaptic interconnections programmed by local spike triggered learning rules such…

Emerging Technologies · Computer Science 2020-03-17 S. R. Nandakumar , Bipin Rajendran

Training large-scale neural networks requires solving nonconvex optimization where the choice of optimizer fundamentally determines both convergence behavior and computational efficiency. While adaptive methods like Adam have long dominated…

Machine Learning · Computer Science 2026-01-30 Chenrui Xu , Wenjing Yan , Ying-Jun Angela Zhang

The primary motor cortex appears to be in the center of transcranial magnetic stimulation (TMS). It is one of few locations that provide directly observable responses, and its physiology serves as model or reference for almost all other TMS…

Neurons and Cognition · Quantitative Biology 2025-07-08 Maryam Farahmandrad , Stefan Goetz

We model the behavioral biases of human decision-making in securing interdependent systems and show that such behavioral decision-making leads to a suboptimal pattern of resource allocation compared to non-behavioral (rational)…

Cryptography and Security · Computer Science 2020-11-25 Mustafa Abdallah , Daniel Woods , Parinaz Naghizadeh , Issa Khalil , Timothy Cason , Shreyas Sundaram , Saurabh Bagchi

We develop an online gradient algorithm for optimizing the performance of product-form networks through online adjustment of control parameters. The use of standard algorithms for finding optimal parameter settings is hampered by the…

Optimization and Control · Mathematics 2012-08-31 Jaron Sanders , Sem C. Borst , Johan S. H. van Leeuwaarden

This paper studies efficient data management and timely information dissemination for real-time monitoring of an $N$-state Markov process, enabling accurate state estimation and reliable actuation decisions. First, we analyze the Age of…

Information Theory · Computer Science 2026-04-02 Mehrdad Salimnejad , Anthony Ephremides , Marios Kountouris , Nikolaos Pappas

Predicting future neural activity is a core challenge in modeling brain dynamics, with applications ranging from scientific investigation to closed-loop neurotechnology. While recent models of population activity emphasize interpretability…

Neurons and Cognition · Quantitative Biology 2026-02-11 Yu Duan , Hamza Tahir Chaudhry , Misha B. Ahrens , Christopher D Harvey , Matthew G Perich , Karl Deisseroth , Kanaka Rajan

In recent years, there is a growing interest in combining techniques attributed to the areas of Statistics and Machine Learning in order to obtain the benefits of both approaches. In this article, the statistical technique lasso for…

Machine Learning · Statistics 2023-09-08 David Delgado , Ernesto Curbelo , Danae Carreras

Recent advances in techniques for monitoring and perturbing neural populations have greatly enhanced our ability to study circuits in the brain. In particular, two-photon holographic optogenetics now enables precise photostimulation of…

Neurons and Cognition · Quantitative Biology 2025-05-09 Andrew Wagenmaker , Lu Mi , Marton Rozsa , Matthew S. Bull , Karel Svoboda , Kayvon Daie , Matthew D. Golub , Kevin Jamieson

Learning-enabled control systems increasingly rely on multiple sensing modalities (e.g., vision, audio, language, etc.) for perception and decision support. A key challenge is that multi-modal sensor training dynamics are often imbalanced:…

Machine Learning · Computer Science 2026-04-01 Heshan Fernando , Quan Xiao , Parikshit Ram , Yi Zhou , Horst Samulowitz , Nathalie Baracaldo , Tianyi Chen

We study the impact of noise on a neural population rate model of up and down states. Up and down states are typically observed in neuronal networks as a slow oscillation, where the population switches between high and low firing rates…

Neurons and Cognition · Quantitative Biology 2015-04-24 Zachary McCleney , Zachary P. Kilpatrick

The human nervous system utilizes synaptic plasticity to solve optimization problems. Previous studies have tried to add the plasticity factor to the training process of artificial neural networks, but most of those models require complex…

Neural and Evolutionary Computing · Computer Science 2022-04-13 Amir Valizadeh

A central challenge in the computational modeling of neural dynamics is the trade-off between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are both experimentally established and essential for neuronal…

One of the primary goals of systems neuroscience is to relate the structure of neural circuits to their function, yet patterns of connectivity are difficult to establish when recording from large populations in behaving organisms. Many…

Machine Learning · Computer Science 2020-12-08 Anne Draelos , Eva A. Naumann , John M. Pearson

In this paper, we investigate the brain activity elicited during perception of animated shapes as stimuli, which have been found to evoke mental state attributions. Contrary to a previous study, we incorporated the participants' responses…

Neurons and Cognition · Quantitative Biology 2023-11-22 Varad Srivastava , Minaxi Goel

In spiking neural networks (SNNs), the main unit of information processing is the neuron with an internal state. The internal state generates an output spike based on its component associated with the membrane potential. This spike is then…

Machine Learning · Computer Science 2025-08-11 Sanja Karilanova , Subhrakanti Dey , Ayça Özçelikkale

Deciphering the underpinnings of the dynamical processes leading to information transmission, processing, and storing in the brain is a crucial challenge in neuroscience. An inspiring but speculative theoretical idea is that such dynamics…

Statistical Mechanics · Physics 2023-07-21 Guillermo B. Morales , Serena Di Santo , Miguel A. Muñoz

Computational neuroscience relies on large-scale dynamical-systems models of neurons, with a vast amount of offline, pre-simulation, tuned parameters, with models often tied to their brain simulators. These fixed parameters lead to stiff…

Neurons and Cognition · Quantitative Biology 2025-12-25 Lennart P. L. Landsmeer , Mario Negrello , Said Hamdioui , Christos Strydis

We consider the information transmission problem in neurons and its possible implications for learning in neural networks. Our approach is based on recent developments in statistical physics and complexity science. Combining sensory…

Neurons and Cognition · Quantitative Biology 2025-09-30 Siddharth Kackar

Spiking Neural Networks (SNNs) can do inference with low power consumption due to their spike sparsity. ANN-SNN conversion is an efficient way to achieve deep SNNs by converting well-trained Artificial Neural Networks (ANNs). However, the…

Neural and Evolutionary Computing · Computer Science 2023-03-24 Xiang He , Yang Li , Dongcheng Zhao , Qingqun Kong , Yi Zeng
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