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The accurate prediction of survival times for patients with severe diseases remains a critical challenge despite recent advances in artificial intelligence. This study introduces "SurvTimeSurvival: Survival Analysis On Patients With…

Machine Learning · Computer Science 2023-11-17 Hung Le , Ong Eng-Jon , Bober Miroslaw

Glioblastoma is profoundly heterogeneous in regional microstructure and vasculature. Characterizing the spatial heterogeneity of glioblastoma could lead to more precise treatment. With unsupervised learning techniques, glioblastoma…

Machine Learning · Computer Science 2021-08-24 Yifan Li , Chao Li , Yiran Wei , Stephen Price , Carola-Bibiane Schönlieb , Xi Chen

The integration of pathologic images and genomic data for survival analysis has gained increasing attention with advances in multimodal learning. However, current methods often ignore biological characteristics, such as heterogeneity and…

Computer Vision and Pattern Recognition · Computer Science 2025-03-28 Shuaiyu Zhang , Xun Lin , Rongxiang Zhang , Yu Bai , Yong Xu , Tao Tan , Xunbin Zheng , Zitong Yu

Multimodal learning leverages complementary information derived from different modalities, thereby enhancing performance in medical image segmentation. However, prevailing multimodal learning methods heavily rely on extensive well-annotated…

Computer Vision and Pattern Recognition · Computer Science 2024-09-05 Xiaogen Zhou , Yiyou Sun , Min Deng , Winnie Chiu Wing Chu , Qi Dou

This study presents a comparative methodological analysis of six machine learning models for survival analysis (MLSA). Using data from nearly 45,000 colorectal cancer patients in the Hospital-Based Cancer Registries of S\~ao Paulo, we…

The accurate prediction of patient prognosis is a critical challenge in clinical practice. With the availability of various patient information, physicians can optimize medical care by closely monitoring disease progression and therapy…

Applications · Statistics 2023-11-28 He Weiyi

Cancer has relational information residing at varying scales, modalities, and resolutions of the acquired data, such as radiology, pathology, genomics, proteomics, and clinical records. Integrating diverse data types can improve the…

Machine Learning · Computer Science 2024-07-29 Asim Waqas , Aakash Tripathi , Ravi P. Ramachandran , Paul Stewart , Ghulam Rasool

Clinical risk prediction models often underperform in real-world settings due to poor calibration, limited transportability, and subgroup disparities. These challenges are amplified in high-dimensional multimodal cancer datasets…

Machine Learning · Computer Science 2026-02-26 Toktam Khatibi

The survival analysis on histological whole-slide images (WSIs) is one of the most important means to estimate patient prognosis. Although many weakly-supervised deep learning models have been developed for gigapixel WSIs, their potential…

Image and Video Processing · Electrical Eng. & Systems 2023-11-06 Pei Liu , Luping Ji , Feng Ye , Bo Fu

Multi-modal learning that combines pathological images with genomic data has significantly enhanced the accuracy of survival prediction. Nevertheless, existing methods have not fully utilized the inherent hierarchical structure within both…

Computer Vision and Pattern Recognition · Computer Science 2024-12-05 Ying Chen , Jiajing Xie , Yuxiang Lin , Yuhang Song , Wenxian Yang , Rongshan Yu

Clinical decision-making in oncology involves multimodal data such as radiology scans, molecular profiling, histopathology slides, and clinical factors. Despite the importance of these modalities individually, no deep learning framework to…

Computer Vision and Pattern Recognition · Computer Science 2021-07-02 Nathaniel Braman , Jacob W. H. Gordon , Emery T. Goossens , Caleb Willis , Martin C. Stumpe , Jagadish Venkataraman

This paper introduces an Ordinary Differential Equation (ODE) notion for survival analysis. The ODE notion not only provides a unified modeling framework, but more importantly, also enables the development of a widely applicable, scalable,…

Methodology · Statistics 2021-12-07 Weijing Tang , Kevin He , Gongjun Xu , Ji Zhu

Multimodal Variational Autoencoders have emerged as a popular tool to extract effective representations from rich multimodal data. However, such models rely on fusion strategies in latent space that destroy the joint statistical structure…

Machine Learning · Computer Science 2026-03-03 Federico Caretti , Guido Sanguinetti

Survival analysis in the presence of multiple possible adverse events, i.e., competing risks, is a pervasive problem in many industries (healthcare, finance, etc.). Since only one event is typically observed, the incidence of an event of…

Machine Learning · Computer Science 2018-08-20 Anton Nemchenko , Trent Kyono , Mihaela Van Der Schaar

Multi-state survival analysis (MSA) uses multi-state models for the analysis of time-to-event data. In medical applications, MSA can provide insights about the complex disease progression in patients. A key challenge in MSA is the accurate…

Machine Learning · Computer Science 2022-07-13 Md Mahmudur Rahman , Sanjay Purushotham

In this paper we propose a semi-supervised variational autoencoder for classification of overall survival groups from tumor segmentation masks. The model can use the output of any tumor segmentation algorithm, removing all assumptions on…

Computer Vision and Pattern Recognition · Computer Science 2020-11-18 Sveinn Pálsson , Stefano Cerri , Andrea Dittadi , Koen Van Leemput

Prognostication for lung cancer, a leading cause of mortality, remains a complex task, as it needs to quantify the associations of risk factors and health events spanning a patient's entire life. One challenge is that an individual's…

Machine Learning · Statistics 2025-08-28 Stephen Salerno , Yi Li

In this paper, we propose a flexible model for survival analysis using neural networks along with scalable optimization algorithms. One key technical challenge for directly applying maximum likelihood estimation (MLE) to censored data is…

Machine Learning · Statistics 2021-12-07 Weijing Tang , Jiaqi Ma , Qiaozhu Mei , Ji Zhu

Survival prediction is a critical task in pathology. In clinical practice, pathologists often examine multiple cases, leveraging a broader spectrum of cancer phenotypes to enhance pathological assessment. Despite significant advancements in…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Xinyang Li , Yi Zhang , Yi Xie , Jianfei Yang , Xi Wang , Hao Chen , Haixian Zhang

One straightforward metric to evaluate a survival prediction model is based on the Mean Absolute Error (MAE) -- the average of the absolute difference between the time predicted by the model and the true event time, over all subjects.…

Machine Learning · Computer Science 2023-06-05 Shi-ang Qi , Neeraj Kumar , Mahtab Farrokh , Weijie Sun , Li-Hao Kuan , Rajesh Ranganath , Ricardo Henao , Russell Greiner
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