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Deploying Large Language Models (LLMs) for healthcare question answering requires robust methods to ensure accuracy and reliability. This work introduces Query-Based Retrieval Augmented Generation (QB-RAG), a framework for enhancing…

Machine Learning · Computer Science 2025-07-31 Eric Yang , Jonathan Amar , Jong Ha Lee , Bhawesh Kumar , Yugang Jia

Retrieval-Augmented Generation (RAG) is widely used to mitigate hallucinations of Large Language Models (LLMs) by leveraging external knowledge. While effective for simple queries, traditional RAG systems struggle with large-scale,…

Computation and Language · Computer Science 2025-11-11 Luyao Zhuang , Shengyuan Chen , Yilin Xiao , Huachi Zhou , Yujing Zhang , Hao Chen , Qinggang Zhang , Xiao Huang

Retrieval-Augmented Generation (RAG) based on Large Language Models (LLMs) is a powerful solution to understand and query the industry's closed-source documents. However, basic RAG often struggles with complex QA tasks in legal and…

Information Retrieval · Computer Science 2025-09-08 Huifeng Lin , Gang Su , Jintao Liang , You Wu , Rui Zhao , Ziyue Li

Retrieval-Augmented Generation (RAG) integrates non-parametric knowledge into Large Language Models (LLMs), typically from unstructured texts and structured graphs. While recent progress has advanced text-based RAG to multi-turn reasoning…

Computation and Language · Computer Science 2025-12-11 Yucan Guo , Miao Su , Saiping Guan , Zihao Sun , Xiaolong Jin , Jiafeng Guo , Xueqi Cheng

The growing demand for efficient and lightweight Retrieval-Augmented Generation (RAG) systems has highlighted significant challenges when deploying Small Language Models (SLMs) in existing RAG frameworks. Current approaches face severe…

Artificial Intelligence · Computer Science 2025-01-28 Tianyu Fan , Jingyuan Wang , Xubin Ren , Chao Huang

Effective incident response (IR) is critical for mitigating cyber threats, yet security teams are overwhelmed by alert fatigue, high false-positive rates, and the vast volume of unstructured Cyber Threat Intelligence (CTI) documents. While…

Cryptography and Security · Computer Science 2025-08-15 Amine Tellache , Abdelaziz Amara Korba , Amdjed Mokhtari , Horea Moldovan , Yacine Ghamri-Doudane

Retrieval Augmented Generation (RAG) has emerged as a crucial technique for enhancing the accuracy of Large Language Models (LLMs) by incorporating external information. With the advent of LLMs that support increasingly longer context…

Machine Learning · Computer Science 2024-11-07 Quinn Leng , Jacob Portes , Sam Havens , Matei Zaharia , Michael Carbin

Artificial intelligence (AI) is reshaping modern healthcare by advancing disease diagnosis, treatment decision-making, and biomedical research. Among AI technologies, large language models (LLMs) have become especially impactful, enabling…

Artificial Intelligence · Computer Science 2025-11-18 Zhengda Wang , Daqian Shi , Jingyi Zhao , Xiaolei Diao , Xiongfeng Tang , Yanguo Qin

Objective: To optimize in-context learning in biomedical natural language processing by improving example selection. Methods: We introduce a novel multi-mode retrieval-augmented generation (MMRAG) framework, which integrates four retrieval…

Computation and Language · Computer Science 2025-02-25 Zaifu Zhan , Jun Wang , Shuang Zhou , Jiawen Deng , Rui Zhang

Retrieval-Augmented Generation (RAG) systems using large language models (LLMs) often generate inaccurate responses due to the retrieval of irrelevant or loosely related information. Existing methods, which operate at the document level,…

Computation and Language · Computer Science 2025-04-24 Ishneet Sukhvinder Singh , Ritvik Aggarwal , Ibrahim Allahverdiyev , Muhammad Taha , Aslihan Akalin , Kevin Zhu , Sean O'Brien

Large Language Models (LLMs) are adept at generating responses based on information within their context. While this ability is useful for interacting with structured data like code files, another popular method, Retrieval-Augmented…

Computation and Language · Computer Science 2025-10-22 Mihir Gupte , Paolo Giusto , Ramesh S

Recent advances in large language models (LLMs) have shown great potential to accelerate drug discovery. However, the specialized nature of biochemical data often necessitates costly domain-specific fine-tuning, posing major challenges.…

Machine Learning · Computer Science 2025-11-17 Namkyeong Lee , Edward De Brouwer , Ehsan Hajiramezanali , Tommaso Biancalani , Chanyoung Park , Gabriele Scalia

In our study, we evaluated large language model (LLM) performance on pharmacy licensure-style question-answering tasks and developed an external knowledge integration method to improve accuracy. We benchmarked ten LLMs with varying…

Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that…

Computation and Language · Computer Science 2024-06-19 Minbyul Jeong , Jiwoong Sohn , Mujeen Sung , Jaewoo Kang

As AI chatbots gain adoption in clinical medicine, developing effective frameworks for complex, emerging diseases presents significant challenges. We developed and evaluated six Retrieval-Augmented Generation (RAG) corpus configurations for…

Artificial Intelligence · Computer Science 2025-10-20 Philip DiGiacomo , Haoyang Wang , Jinrui Fang , Yan Leng , W Michael Brode , Ying Ding

Retrieval-augmented generation (RAG) improves the response quality of large language models (LLMs) by retrieving knowledge from external databases. Typical RAG approaches split the text database into chunks, organizing them in a flat…

Computation and Language · Computer Science 2025-11-18 Boyu Chen , Zirui Guo , Zidan Yang , Yuluo Chen , Junze Chen , Zhenghao Liu , Chuan Shi , Cheng Yang

Retrieval-augmented generation (RAG) frameworks enable large language models (LLMs) to retrieve relevant information from a knowledge base and incorporate it into the context for generating responses. This mitigates hallucinations and…

Computation and Language · Computer Science 2024-04-09 Pouria Rouzrokh , Shahriar Faghani , Cooper U. Gamble , Moein Shariatnia , Bradley J. Erickson

The recent emergence of Medical Large Vision Language Models (Med-LVLMs) has enhanced medical diagnosis. However, current Med-LVLMs frequently encounter factual issues, often generating responses that do not align with established medical…

Machine Learning · Computer Science 2024-10-18 Peng Xia , Kangyu Zhu , Haoran Li , Hongtu Zhu , Yun Li , Gang Li , Linjun Zhang , Huaxiu Yao

Reconstructing precise clinical timelines is essential for modeling patient trajectories and forecasting risk in complex, heterogeneous conditions like sepsis. While unstructured clinical narratives offer semantically rich and contextually…

Computation and Language · Computer Science 2026-05-15 Sayantan Kumar , Shahriar Noroozizadeh , Juyong Kim , Jeremy C. Weiss

Retrieval Augmented Generation (RAG) frameworks have shown significant promise in leveraging external knowledge to enhance the performance of large language models (LLMs). However, conventional RAG methods often retrieve documents based…

Computation and Language · Computer Science 2025-04-02 Pouya Pezeshkpour , Estevam Hruschka
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