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The manipulation of microparticles using optical forces has led to many applications in the life and physical sciences. To extend optical trapping towards the nano-regime, in this work we demonstrate trapping of single nanoparticles in…

A stable added-mass partitioned (AMP) algorithm is developed for fluid-structure interaction (FSI) problems involving viscous incompressible flow and compressible elastic solids. Deforming composite grids are used to effectively handle the…

Numerical Analysis · Mathematics 2019-10-23 Daniel A. Serino , Jeffrey W. Banks , William D. Henshaw , Donald W. Schwendeman

Usage, manipulation, transport, delivery, and mixing of granular or particulate media, comprised of spherical or polyhedral particles, is commonly encountered in industrial sectors of construction (cement and rock fragments), pharmaceutics…

Computational Engineering, Finance, and Science · Computer Science 2021-02-25 Prashant K. Jha , Prathamesh S. Desai , Debdeep Bhattacharya , Robert Lipton

Microfluidics has revolutionized control over small volumes through the use of physical barriers. However, the rigidity of these barriers limits flexibility in applications. We present an optofluidic toolbox that leverages structured light…

A discrete unified gas kinetic scheme (DUGKS) coupled with the immersed boundary (IB) method is developed to perform interface-resolved simulation of particle-laden flows. The present method (IB-DUGKS) preserves the respective advantages of…

Fluid Dynamics · Physics 2018-10-17 Shi Tao , Haolong Zhang , Zhaoli Guo , Lian-Ping Wang

A micromorphic computational homogenization framework has recently been developed to deal with materials showing long-range correlated interactions, i.e. displaying patterning modes. Typical examples of such materials are elastomeric…

Soft Condensed Matter · Physics 2024-06-21 S. Maraghechi , O. Rokoš , R. H. J. Peerlings , M. G. D. Geers , J. P. M. Hoefnagels

Polydimethylsiloxane (PDMS) microfluidic devices have become a standard tool for engineering cells and multicellular networks in vitro. However, the reservoirs, or through-holes where cells access the devices, are usually fabricated…

Applied Physics · Physics 2020-12-02 Taiki Takemuro , Hideaki Yamamoto , Shigeo Sato , Ayumi Hirano-Iwata

The magnetohydrodynamics (MHD) equations are continuum models used in the study of a wide range of plasma physics systems, including the evolution of complex plasma dynamics in tokamak disruptions. However, efficient numerical solution…

Computational Physics · Physics 2022-02-09 Qi Tang , Luis Chacon , Tzanio V. Kolev , John N. Shadid , Xian-Zhu Tang

We demonstrate and explain a simple and efficient way to remove gas bubbles from liquid-filled microchannels, by integrating a hydrophobic porous membrane on top of the microchannel. A prototype chip is manufactured in hard, transparent…

Fluid Dynamics · Physics 2010-05-04 Jie Xu , Regis Vaillant , Daniel Attinger

Inertial microfluidic is able to focus and separate particles in microchannels based on the characteristic geometry and intrinsic hydrodynamic effect. Yet, the vertical position of suspended particles in the microchannel cannot be…

Fluid Dynamics · Physics 2022-07-22 Chengliang Xuan , Weiyin Liang , Bing He , Binghai Wen

The deformation and rupture of a lipid vesicle due to the forced normal approach of an inclusion are essential for optimizing the design of magnetic giant unilamellar vesicles [magGUVs, Malik et al., Nanoscale 17, 13720 (2025)], with…

Soft Condensed Matter · Physics 2025-12-16 Yuan-Nan Young , Bryan Quaife , Herve Nganguia , On Shun Pak , Jie Feng , Howard A. Stone

Microfluidic chips provide unparalleled control over droplets and jets, which have advanced all natural sciences. However, microfluidic applications could be vastly expanded by increasing the per-channel throughput and directly exploiting…

Simulating the deformation of fractured media requires the coupling of different models for the deformation of fractures and the formation surrounding them. We consider a cell-centered finite-volume approach, termed the multipoint stress…

Numerical Analysis · Mathematics 2018-03-21 Eren Ucar , Eirik Keilegavlen , Inga Berre , Jan Martin Nordbotten

This paper introduces a unified model for thermo-poroelasticity and multiple-network poroelasticity, reformulated into a total-pressure-based system. We first establish the well-posedness of the problem via a Galerkin-based argument and…

Numerical Analysis · Mathematics 2026-04-01 Huipeng Gu , Mingchao Cai , Jingzhi Li , Yu Jiang

In microfluidic systems, droplets undergo intricate deformations as they traverse flow-focusing junctions, posing a challenging task for accurate measurement, especially during short transit times. This study investigates the physical…

Fluid-particle systems are very common in many natural processes and engineering applications. However, accurately and efficiently modelling fluid-particle systems with complex particle shapes is still a challenging task. Here, we present a…

Fluid Dynamics · Physics 2023-03-22 Pei Zhang , Ling Qiu , S. A. Galindo-Torres , Yilin Chen , A. Scheuermann , Ling Li

In this paper we propose an efficient second order well balanced finite volume method for modeling complex free surface flows at the aid of a simple diffuse interface method. The employed physical model is a two-phase model derived from the…

Numerical Analysis · Mathematics 2018-08-16 Elena Gaburro , Manuel J. Castro , Michael Dumbser

Transport of microscopic objects across biological membranes usually involves membrane deformation to enclose the object followed by detachment of the engulfed particle. However, in artificial membranes, this last topological remodelling…

Soft Condensed Matter · Physics 2025-03-25 Florent Fessler , Pierre Muller , Antonio Stocco

Precise manipulation of fluids and objects on the micro scale is seldom a simple task, but nevertheless crucial for many applications in life sciences and chemical engineering. We present a microfluidic chip fabricated in silicon-glass,…

The ability of detecting and separating CTCs can play a key role in early cancer detection and treatment. In recent years, there has been growing interest in using deformability-based CTC separation microfilters due to their simplicity and…

Cell Behavior · Quantitative Biology 2016-01-11 Mohammad Aghaamoo , Zhifeng Zhang , Xiaolin Chen , Jie Xu