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Real-world clinical practice demands multi-image comparative reasoning, yet current medical benchmarks remain limited to single-frame interpretation. We present MedFrameQA, the first benchmark explicitly designed to test multi-image medical…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Suhao Yu , Haojin Wang , Juncheng Wu , Luyang Luo , Jingshen Wang , Cihang Xie , Pranav Rajpurkar , Carl Yang , Yang Yang , Kang Wang , Yannan Yu , Yuyin Zhou

Medical large language models (LLMs) achieve impressive performance on standardized benchmarks, yet these evaluations fail to capture the complexity of real clinical encounters where patients exhibit memory gaps, limited health literacy,…

Artificial Intelligence · Computer Science 2026-04-14 Sina Mansouri , Mohit Marvania , Vibhavari Ashok Shihorkar , Han Ngoc Tran , Kazhal Shafiei , Mehrdad Fazli , Yikuan Li , Ziwei Zhu

Individuals are increasingly generating substantial personal health and lifestyle data, e.g. through wearables and smartphones. While such data could transform preventative care, its integration into clinical practice is hindered by its…

Human-Computer Interaction · Computer Science 2026-02-16 Pavithren V S Pakianathan , Rania Islambouli , Diogo Branco , Albrecht Schmidt , Tiago Guerreiro , Jan David Smeddinck

Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models trained for a specific task. Training such models…

Image and Video Processing · Electrical Eng. & Systems 2025-12-18 Anwai Archit , Luca Freckmann , Constantin Pape

Artificial intelligence (AI) is reshaping modern healthcare by advancing disease diagnosis, treatment decision-making, and biomedical research. Among AI technologies, large language models (LLMs) have become especially impactful, enabling…

Artificial Intelligence · Computer Science 2025-11-18 Zhengda Wang , Daqian Shi , Jingyi Zhao , Xiaolei Diao , Xiongfeng Tang , Yanguo Qin

In recent years, the field of radiology has increasingly harnessed the power of artificial intelligence (AI) to enhance diagnostic accuracy, streamline workflows, and improve patient care. Large language models (LLMs) have emerged as…

Computation and Language · Computer Science 2024-12-17 Yucheng Shi , Peng Shu , Zhengliang Liu , Zihao Wu , Quanzheng Li , Tianming Liu , Ninghao Liu , Xiang Li

Synthesizing clinical evidence largely relies on systematic reviews of clinical trials and retrospective analyses from medical literature. However, the rapid expansion of publications presents challenges in efficiently identifying,…

Computation and Language · Computer Science 2024-10-30 Zifeng Wang , Lang Cao , Benjamin Danek , Qiao Jin , Zhiyong Lu , Jimeng Sun

The rapid development of AI-generated content (AIGC) technology has led to the misuse of highly realistic AI-generated images (AIGI) in spreading misinformation, posing a threat to public information security. Although existing AIGI…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Ziyin Zhou , Yunpeng Luo , Yuanchen Wu , Ke Sun , Jiayi Ji , Ke Yan , Shouhong Ding , Xiaoshuai Sun , Yunsheng Wu , Rongrong Ji

Artificial intelligence (AI) that can effectively learn ultrasound representations by integrating multi-source data holds significant promise for advancing clinical care. However, the scarcity of large labeled datasets in real-world…

Models such as GPT-4 and Med-PaLM 2 have demonstrated impressive performance on a wide variety of biomedical NLP tasks. However, these models have hundreds of billions of parameters, are computationally expensive to run, require users to…

Vision-and-language multi-modal pretraining and fine-tuning have shown great success in visual question answering (VQA). Compared to general domain VQA, the performance of biomedical VQA suffers from limited data. In this paper, we propose…

Computer Vision and Pattern Recognition · Computer Science 2023-03-02 Zheng Yuan , Qiao Jin , Chuanqi Tan , Zhengyun Zhao , Hongyi Yuan , Fei Huang , Songfang Huang

Foundational models (FMs) have made significant strides in the healthcare domain. Yet the data silo challenge and privacy concern remain in healthcare systems, hindering safe medical data sharing and collaborative model development among…

Machine Learning · Computer Science 2025-02-27 Zheling Tan , Kexin Ding , Jin Gao , Mu Zhou , Dimitris Metaxas , Shaoting Zhang , Dequan Wang

Most current medical vision language models struggle to jointly generate diagnostic text and pixel-level segmentation masks in response to complex visual questions. This represents a major limitation towards clinical application, as…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Chengrun Li , Corentin Royer , Haozhe Luo , Bastian Wittmann , Xia Li , Ibrahim Hamamci , Sezgin Er , Anjany Sekuboyina , Bjoern Menze

Generative medical AI now appears fluent and knowledgeable enough to resemble clinical intelligence, encouraging the belief that scaling will make it safe. But clinical reasoning is not text generation. It is a responsibility-bound process…

Artificial Intelligence · Computer Science 2026-02-02 Vaibhav Ram S. V. N. S , Swetanshu Agrawal , Samudra Banerjee , Abdul Muhsin

The integration of deep learning-based glaucoma detection with large language models (LLMs) presents an automated strategy to mitigate ophthalmologist shortages and improve clinical reporting efficiency. However, applying general LLMs to…

Multiagent Systems · Computer Science 2025-12-18 Philip R. Liu , Sparsh Bansal , Jimmy Dinh , Aditya Pawar , Ramani Satishkumar , Shail Desai , Neeraj Gupta , Xin Wang , Shu Hu

We present ReXVQA, the largest and most comprehensive benchmark for visual question answering (VQA) in chest radiology, comprising approximately 696,000 questions paired with 160,000 chest X-rays studies across training, validation, and…

Computer Vision and Pattern Recognition · Computer Science 2025-06-06 Ankit Pal , Jung-Oh Lee , Xiaoman Zhang , Malaikannan Sankarasubbu , Seunghyeon Roh , Won Jung Kim , Meesun Lee , Pranav Rajpurkar

We investigate fine-tuning Vision-Language Models (VLMs) for multi-task medical image understanding, focusing on detection, localization, and counting of findings in medical images. Our objective is to evaluate whether instruction-tuned…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Sushant Gautam , Michael A. Riegler , Pål Halvorsen

In healthcare tabular predictions, classical models with feature engineering often outperform neural approaches. Recent advances in Large Language Models enable the integration of domain knowledge into feature engineering, offering a…

Machine Learning · Computer Science 2026-03-04 Zizheng Zhang , Yiming Li , Justin Xu , Jinyu Wang , Rui Wang , Lei Song , Jiang Bian , David W Eyre , Jingjing Fu

Visual grounding is essential for precise perception and reasoning in multimodal large language models (MLLMs), especially in medical imaging domains. While existing medical visual grounding benchmarks primarily focus on single-image…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Jingkun Yue , Siqi Zhang , Zinan Jia , Huihuan Xu , Zongbo Han , Xiaohong Liu , Guangyu Wang

The integration of artificial intelligence (AI) with radiology marks a transformative era in medicine. Vision foundation models have been adopted to enhance radiologic imaging analysis. However, the distinct complexities of radiologic 2D…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Zhixiu Lu , Hailong Li , Nehal A. Parikh , Jonathan R. Dillman , Lili He
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