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Whole Slide Image (WSI) analysis is a powerful method to facilitate the diagnosis of cancer in tissue samples. Automating this diagnosis poses various issues, most notably caused by the immense image resolution and limited annotations. WSIs…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Ahmet Gokberk Gul , Oezdemir Cetin , Christoph Reich , Tim Prangemeier , Nadine Flinner , Heinz Koeppl

In the field of computational histopathology, both whole slide images (WSIs) and diagnostic captions provide valuable insights for making diagnostic decisions. However, aligning WSIs with diagnostic captions presents a significant…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Qifeng Zhou , Wenliang Zhong , Yuzhi Guo , Michael Xiao , Hehuan Ma , Junzhou Huang

Recent developments in the field of non-local attention (NLA) have led to a renewed interest in self-similarity-based single image super-resolution (SISR). Researchers usually used the NLA to explore non-local self-similarity (NSS) in SISR…

Computer Vision and Pattern Recognition · Computer Science 2023-05-26 Jian-Nan Su , Min Gan , Guang-Yong Chen , Wenzhong Guo , C. L. Philip Chen

Quantitative characterization of cellular spatial organization is critical for understanding tumor progression and immune response. Recent advances in artificial intelligence (AI) enable large-scale segmentation and classification of nuclei…

Learning good representation of giga-pixel level whole slide pathology images (WSI) for downstream tasks is critical. Previous studies employ multiple instance learning (MIL) to represent WSIs as bags of sampled patches because, for most…

Computer Vision and Pattern Recognition · Computer Science 2022-12-01 Chunyuan Li , Xinliang Zhu , Jiawen Yao , Junzhou Huang

One of the main obstacles of adopting digital pathology is the challenge of efficient processing of hyperdimensional digitized biopsy samples, called whole slide images (WSIs). Exploiting deep learning and introducing compact WSI…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Azam Asilian Bidgoli , Shahryar Rahnamayan , Taher Dehkharghanian , Abtin Riasatian , H. R. Tizhoosh

Multi-instance learning (MIL) is widely used in the computer-aided interpretation of pathological Whole Slide Images (WSIs) to solve the lack of pixel-wise or patch-wise annotations. Often, this approach directly applies "natural image…

Histopathological image segmentation is a laborious and time-intensive task, often requiring analysis from experienced pathologists for accurate examinations. To reduce this burden, supervised machine-learning approaches have been adopted…

Computer Vision and Pattern Recognition · Computer Science 2024-09-12 Vishnuvardhan Purma , Suhas Srinath , Seshan Srirangarajan , Aanchal Kakkar , Prathosh A. P

While Whole Slide Imaging (WSI) scanners remain the gold standard for digitizing pathology samples, their high cost limits accessibility in many healthcare settings. Other low-cost solutions also face critical limitations: automated…

Computer Vision and Pattern Recognition · Computer Science 2025-10-08 Yousef Yeganeh , Maximilian Frantzen , Michael Lee , Kun-Hsing Yu , Nassir Navab , Azade Farshad

Building accurate and robust artificial intelligence systems for medical image assessment requires not only the research and design of advanced deep learning models but also the creation of large and curated sets of annotated training…

Computer Vision and Pattern Recognition · Computer Science 2022-01-05 Florin C. Ghesu , Bogdan Georgescu , Awais Mansoor , Youngjin Yoo , Dominik Neumann , Pragneshkumar Patel , R. S. Vishwanath , James M. Balter , Yue Cao , Sasa Grbic , Dorin Comaniciu

Multiple instance learning is an ideal mode of analysis for histopathology data, where vast whole slide images are typically annotated with a single global label. In such cases, a whole slide image is modelled as a collection of tissue…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Leo Fillioux , Joseph Boyd , Maria Vakalopoulou , Paul-Henry Cournède , Stergios Christodoulidis

We present a pioneering investigation into the application of deep learning techniques to analyze histopathological images for addressing the substantial challenge of automated prognostic prediction. Prognostic prediction poses a unique…

Chen et al. [Chen2022] recently published the article 'Fast and scalable search of whole-slide images via self-supervised deep learning' in Nature Biomedical Engineering. The authors call their method 'self-supervised image search for…

Image and Video Processing · Electrical Eng. & Systems 2023-06-16 Milad Sikaroudi , Mehdi Afshari , Abubakr Shafique , Shivam Kalra , H. R. Tizhoosh

Ensuring diagnostic performance of AI models before clinical use is key to the safe and successful adoption of these technologies. Studies reporting AI applied to digital pathology images for diagnostic purposes have rapidly increased in…

Although the Segment Anything Model (SAM) is highly effective in natural image segmentation, it requires dependencies on prompts, which limits its applicability to medical imaging where manual prompts are often unavailable. Existing efforts…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Mengmeng Zhang , Xingyuan Dai , Yicheng Sun , Jing Wang , Yueyang Yao , Xiaoyan Gong , Fuze Cong , Feiyue Wang , Yisheng Lv

Current multi-instance learning algorithms for pathology image analysis often require a substantial number of Whole Slide Images for effective training but exhibit suboptimal performance in scenarios with limited learning data. In clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Linhao Qu , Dingkang Yang , Dan Huang , Qinhao Guo , Rongkui Luo , Shaoting Zhang , Xiaosong Wang

We present a novel weakly-supervised framework for classifying whole slide images (WSIs). WSIs, due to their gigapixel resolution, are commonly processed by patch-wise classification with patch-level labels. However, patch-level labels…

Computer Vision and Pattern Recognition · Computer Science 2022-03-10 Tiange Xiang , Yang Song , Chaoyi Zhang , Dongnan Liu , Mei Chen , Fan Zhang , Heng Huang , Lauren O'Donnell , Weidong Cai

A Whole Slide Image (WSI) is a high-resolution digital image created by scanning an entire glass slide containing a biological specimen, such as tissue sections or cell samples, at multiple magnifications. These images are digitally…

Annotating cancerous regions in whole-slide images (WSIs) of pathology samples plays a critical role in clinical diagnosis, biomedical research, and machine learning algorithms development. However, generating exhaustive and accurate…

Computer Vision and Pattern Recognition · Computer Science 2022-06-09 Zhenzhen Wang , Carla Saoud , Sintawat Wangsiricharoen , Aaron W. James , Aleksander S. Popel , Jeremias Sulam

We propose an exhaustive methodology that leverages all levels of feature abstraction, targeting an enhancement in the generalizability of image classification to unobserved hospitals. Our approach incorporates augmentation-based…

Computer Vision and Pattern Recognition · Computer Science 2023-08-10 Milad Sikaroudi , Maryam Hosseini , Shahryar Rahnamayan , H. R. Tizhoosh
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