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In genomics, differential abundance and expression analyses are complicated by the compositional nature of sequence count data, which reflect only relative-not absolute-abundances or expression levels. Many existing methods attempt to…

Methodology · Statistics 2025-12-16 Won Gu , Francesca Chiaromonte , Justin D. Silverman

In recent years, diffusion models trained on equilibrium molecular distributions have proven effective for sampling biomolecules. Beyond direct sampling, the score of such a model can also be used to derive the forces that act on molecular…

Machine Learning · Computer Science 2026-01-15 Michael Plainer , Hao Wu , Leon Klein , Stephan Günnemann , Frank Noé

We present FlowSN, a statistical framework using simulation-based inference (SBI) with normalising flows to account for selection effects in observational astronomy. Failure to account for selection effects can lead to biased inference on…

We study the s-process abundances at the epoch of the Solar-system formation as the outcome of nucleosynthesis occurring in AGB stars of various masses and metallicities. The calculations have been performed with the Galactic chemical…

Solar and Stellar Astrophysics · Physics 2013-11-22 S. Bisterzo , C. Travaglio , M. Wiescher , R. Gallino , F. Kaeppeler , O. Straniero , S. Cristallo , G. Imbriani , J. Goerres , R. J. deBoer

Measurements of the Ly$\alpha$ forest based on large numbers of quasar spectra from sky surveys such as SDSS/eBOSS accurately probe the distribution of matter on small scales and thus provide important constraints on several ingredients of…

Cosmology and Nongalactic Astrophysics · Physics 2021-04-22 Michael Walther , Eric Armengaud , Corentin Ravoux , Nathalie Palanque-Delabrouille , Christophe Yèche , Zarija Lukić

Inferring dependencies between complex biological traits while accounting for evolutionary relationships between specimens is of great scientific interest yet remains infeasible when trait and specimen counts grow large. The…

We test the robustness of simulation-based inference (SBI) in the context of cosmological parameter estimation from galaxy cluster counts and masses in simulated optical datasets. We construct ``simulations'' using analytical models for the…

Cosmology and Nongalactic Astrophysics · Physics 2024-10-01 Moonzarin Reza , Yuanyuan Zhang , Camille Avestruz , Louis E. Strigari , Simone Shevchuk , Francisco Villaescusa-Navarro

Aims. We aim to perform consistent comparisons between observations and simulations on the mass dependence of the galaxy major merger fraction at low redshift over an unprecedentedly wide range of stellar masses (10^9 to 10^12 solar…

Astrophysics of Galaxies · Physics 2021-01-04 L. Wang , W. J. Pearson , V. Rodriguez-Gomez

Interactive composition simulations in Earth System Models (ESMs) are computationally expensive as they transport numerous gaseous and aerosol tracers at each timestep. This limits higher-resolution transient climate simulations with…

Atmospheric and Oceanic Physics · Physics 2025-10-14 Seyed Mohammad Hassan Erfani , Kara Lamb , Susanne Bauer , Kostas Tsigaridis , Marcus van Lier-Walqui , Gavin Schmidt

Many scientific models are composed of multiple discrete components, and scientists often make heuristic decisions about which components to include. Bayesian inference provides a mathematical framework for systematically selecting model…

Machine Learning · Computer Science 2024-05-31 Cornelius Schröder , Jakob H. Macke

It has become increasingly common to collect high-dimensional binary response data; for example, with the emergence of new sampling techniques in ecology. In smaller dimensions, multivariate probit (MVP) models are routinely used for…

Methodology · Statistics 2022-10-26 Antik Chakraborty , Rihui Ou , David B. Dunson

We introduce a Bayesian solution to the problem of inferring the density profile of strong gravitational lenses when the lens galaxy may contain multiple dark or faint substructures. The source and lens models are based on a superposition…

Instrumentation and Methods for Astrophysics · Physics 2015-10-12 Brendon J. Brewer , David Huijser , Geraint F. Lewis

Generative models are a promising tool to produce cosmological simulations but face significant challenges in scalability, physical consistency, and adherence to domain symmetries, limiting their utility as alternatives to $N$-body…

Cosmology and Nongalactic Astrophysics · Physics 2025-08-26 Diana-Alexandra Onutu , Yue Zhao , Joaquin Vanschoren , Vlado Menkovski

This work describes the implementation and application of a correlation determination method based on Self Organizing Maps and Bayesian Inference (SOMBI). SOMBI aims to automatically identify relations between different observed parameters…

Cosmology and Nongalactic Astrophysics · Physics 2016-11-02 Philipp Frank , Jens Jasche , Torsten A. Enßlin

In this work, we compare large scale structure observables for stellar mass selected samples at $z=0$, as predicted by two galaxy models, the hydrodynamical simulation IllustrisTNG and the Santa-Cruz semi-analytic model (SC-SAM). Although…

Cosmology and Nongalactic Astrophysics · Physics 2021-09-22 Boryana Hadzhiyska , Sonya Liu , Rachel S. Somerville , Austen Gabrielpillai , Sownak Bose , Daniel Eisenstein , Lars Hernquist

Diffusion models benefit from instillation of task-specific information into the score function to steer the sample generation towards desired properties. Such information is coined as guidance. For example, in text-to-image synthesis, text…

Machine Learning · Computer Science 2024-03-05 Yuchen Wu , Minshuo Chen , Zihao Li , Mengdi Wang , Yuting Wei

The abundance of galaxy clusters as a function of mass and redshift is a well-established and powerful cosmological probe. Cosmological analyses based on galaxy cluster number counts have traditionally relied on explicitly computed…

Cosmology and Nongalactic Astrophysics · Physics 2025-04-15 Íñigo Zubeldia , Boris Bolliet , Anthony Challinor , William Handley

Phylogenetic methods, traditionally used in biology to trace the evolutionary relationships among species, are emerging as a powerful framework to reconstruct evolutionary processes in galaxies from chemical information. We apply galactic…

Mechanistic simulation models are inverted against observations in order to gain inference on modeled processes. However, with the increasing ability to collect high resolution observations, these observations represent more patterns of…

Computation · Statistics 2018-12-20 Thomas Wutzler

This paper deals with Gibbs samplers that include high dimensional conditional Gaussian distributions. It proposes an efficient algorithm that avoids the high dimensional Gaussian sampling and relies on a random excursion along a small set…

Computation · Statistics 2016-04-20 Olivier Féron , François Orieux , Jean-François Giovannelli
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