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A vast array of transformative technologies developed over the past decade has enabled measurement and perturbation at ever increasing scale, yet our understanding of many systems remains limited by experimental capacity. Overcoming this…

Quantitative Methods · Quantitative Biology 2020-12-25 Brian Cleary , Aviv Regev

Data Science and Machine learning have been growing strong for the past decade. We argue that to make the most of this exciting field we should resist the temptation of assuming that forecasting can be reduced to brute-force data analytics.…

Artificial Intelligence · Computer Science 2020-05-12 Hykel Hosni , Angelo Vulpiani

Biological intelligence is remarkable in its ability to produce complex behaviour in many diverse situations through data efficient, generalisable and transferable skill acquisition. It is believed that learning "good" sensory…

Neurons and Cognition · Quantitative Biology 2022-03-18 Irina Higgins , Sébastien Racanière , Danilo Rezende

Inferring from inconsistency and making decisions are two problems which have always been treated separately by researchers in Artificial Intelligence. Consequently, different models have been proposed for each category. Different…

Artificial Intelligence · Computer Science 2012-07-09 Leila Amgoud

While Moore's law has driven exponential computing power expectations, its nearing end calls for new avenues for improving the overall system performance. One of these avenues is the exploration of alternative brain-inspired computing…

Neural and Evolutionary Computing · Computer Science 2023-05-16 Charlotte Frenkel , David Bol , Giacomo Indiveri

Community and core-periphery are two widely studied graph structures, with their coexistence observed in real-world graphs (Rombach, Porter, Fowler \& Mucha [SIAM J. App. Math. 2014, SIAM Review 2017]). However, the nature of this…

Machine Learning · Computer Science 2024-06-10 Chandra Sekhar Mukherjee , Jiapeng Zhang

Despite their widespread utility across domains, basic network models face fundamental limitations when applied to complex biological systems, particularly in neuroscience. This paper critically examines these limitations and explores…

Other Quantitative Biology · Quantitative Biology 2024-11-07 Luiz Pessoa

Principal Component Analysis and biplots are so well-established and readily implemented that it is just too tempting to give for granted their internal workings. In this note I get back to basics in comparing how PCA and biplots are…

Methodology · Statistics 2025-09-03 Ettore Settanni

The concept of autonomy is key to the IoT vision promising increasing integration of smart services and systems minimizing human intervention. This vision challenges our capability to build complex open trustworthy autonomous systems. We…

Systems and Control · Computer Science 2018-11-27 Joseph Sifakis

The Blackboard Architecture provides a mechanism for embodying data, decision making and actuation. Its versatility has been demonstrated across a wide number of application areas. However, it lacks the capability to directly model…

Artificial Intelligence · Computer Science 2023-06-08 Jonathan Rivard , Jeremy Straub

Determining whether another system, biological or artificial, possesses phenomenal consciousness has long been a central challenge in consciousness studies. This attribution problem has become especially pressing with the rise of large…

Artificial Intelligence · Computer Science 2025-09-23 Fangfang Li , Xiaojie Zhang

The rapid evolution of artificial intelligence has led to expectations of transformative impact on science, yet current systems remain fundamentally limited in enabling genuine scientific discovery. This perspective contends that progress…

Artificial Intelligence · Computer Science 2025-12-16 Karthik Duraisamy

We have designed a machine that becomes increasingly better at behaving in underspecified circumstances, in a goal-directed way, on the job, by modeling itself and its environment as experience accumulates. Based on principles of…

We study core-periphery structure in networks using inference methods based on a flexible network model that allows for traditional onion-like cores within cores, but also for hierarchical tree-like structures and more general non-nested…

Social and Information Networks · Computer Science 2023-08-25 Austin Polanco , M. E. J. Newman

Within the limited scope of this paper, we argue that artificial general intelligence cannot emerge from current neural network paradigms regardless of scale, nor is such an approach healthy for the field at present. Drawing on various…

Artificial Intelligence · Computer Science 2025-11-25 Khanh Gia Bui

Many real-world networks are theorized to have core-periphery structure consisting of a densely-connected core and a loosely-connected periphery. While this phenomenon has been extensively studied in a range of scientific disciplines, it…

Methodology · Statistics 2023-02-21 Eric Yanchenko , Srijan Sengupta

The introduction of large language models has significantly expanded global demand for computing; addressing this growing demand requires novel approaches that introduce new capabilities while addressing extant needs. Although inspiration…

Neural and Evolutionary Computing · Computer Science 2026-02-04 Wilkie Olin-Ammentorp

Real-world generalization, e.g., deciding to approach a never-seen-before animal, relies on contextual information as well as previous experiences. Such a seemingly easy behavioral choice requires the interplay of multiple neural…

Neurons and Cognition · Quantitative Biology 2022-01-17 Peer Herholz , Eddy Fortier , Mariya Toneva , Nicolas Farrugia , Leila Wehbe , Valentina Borghesani

Neuromorphic computing seeks to replicate the remarkable efficiency, flexibility, and adaptability of the human brain in artificial systems. Unlike conventional digital approaches, which suffer from the Von Neumann bottleneck and depend on…

Artificial Intelligence · Computer Science 2025-11-04 Marcel van Gerven

Constraint-based causal discovery is widely used for learning causal structures, but heavy reliance on conditional independence (CI) testing makes it computationally expensive in high-dimensional settings. To mitigate this limitation, many…

Machine Learning · Computer Science 2026-05-12 Zheng Li , Feng Xie , Shenglan Nie , Xichen Guo , Ruxin Wang , Hao Zhang