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With the increasing incidence of neurodegenerative diseases such as Alzheimer's Disease (AD), there is a need for further research that enhances detection and monitoring of the diseases. We present MORPHADE (Morphological Autoencoders for…

Image and Video Processing · Electrical Eng. & Systems 2024-07-08 Mehmet Yigit Avci , Emily Chan , Veronika Zimmer , Daniel Rueckert , Benedikt Wiestler , Julia A. Schnabel , Cosmin I. Bercea

Alzheimer's dementia (AD) is a neurodegenerative disorder with cognitive decline that commonly impacts language ability. This work extends the paired perplexity approach to detecting AD by using a recent large language model (LLM), the…

Computation and Language · Computer Science 2025-06-12 Yao Xiao , Heidi Christensen , Stefan Goetze

Alzheimer's disease (AD) stands as the predominant cause of dementia, characterized by a gradual decline in speech and language capabilities. Recent deep-learning advancements have facilitated automated AD detection through spontaneous…

Computation and Language · Computer Science 2024-09-20 Chin-Po Chen , Jeng-Lin Li

Positron Emission Tomography (PET) is now regarded as the gold standard for the diagnosis of Alzheimer's Disease (AD). However, PET imaging can be prohibitive in terms of cost and planning, and is also among the imaging techniques with the…

The rapid global aging trend has led to an increase in dementia cases, including Alzheimer's disease, underscoring the urgent need for early and accurate diagnostic methods. Traditional diagnostic techniques, such as cognitive tests,…

Machine Learning · Computer Science 2024-09-06 Juan A. Berrios Moya

There is a need for automatic diagnosis of certain diseases from medical images that could help medical practitioners for further assessment towards treating the illness. Alzheimers disease is a good example of a disease that is often…

Image and Video Processing · Electrical Eng. & Systems 2019-01-30 GuruRaj Awate

Alzheimer's disease is one of the diseases that mostly affects older people without being a part of aging. The most common symptoms include problems with communicating and abstract thinking, as well as disorientation. It is important to…

Image and Video Processing · Electrical Eng. & Systems 2020-12-01 Fatih Altay , Guillermo Ramon Sanchez , Yanli James , Stephen V. Faraone , Senem Velipasalar , Asif Salekin

Existing research has shown the potential of classifying Alzheimers Disease (AD) from eye-tracking (ET) data with classifiers that rely on task-specific engineered features. In this paper, we investigate whether we can improve on existing…

Computer Vision and Pattern Recognition · Computer Science 2023-09-25 Harshinee Sriram , Cristina Conati , Thalia Field

The current state-of-the-art deep neural networks (DNNs) for Alzheimer's Disease diagnosis use different biomarker combinations to classify patients, but do not allow extracting knowledge about the interactions of biomarkers. However, to…

Machine Learning · Computer Science 2021-09-28 Raphael Ronge , Kwangsik Nho , Christian Wachinger , Sebastian Pölsterl

Alzheimer's Disease and normal aging are both characterized by brain atrophy. The question of whether AD-related brain atrophy represents accelerated aging or a neurodegeneration process distinct from that in normal aging remains…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Jingru Fu , Daniel Ferreira , Örjan Smedby , Rodrigo Moreno

Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects cognitive functions such as memory, thinking, and behavior. In this disease, there is a critical phase, mild cognitive impairment, that is really…

Signal Processing · Electrical Eng. & Systems 2024-04-02 Arezoo Borji , Taha-Hossein Hejazi , Abbas Seifi

Objective: This paper presents an Alzheimer's disease (AD) detection method based on learning structural similarity between Magnetic Resonance Images (MRIs) and representing this similarity as a graph. Methods: We construct the similarity…

Computer Vision and Pattern Recognition · Computer Science 2021-03-01 Kuo Yang , Emad A. Mohammed , Behrouz H. Far

The current methods for diagnosing Alzheimer Disease using Magnetic Resonance Imaging (MRI) have significant limitations. Many previous studies used 2D Transformers to analyze individual brain slices independently, potentially losing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Juan A. Castro-Silva , Maria N. Moreno Garcia , Diego H. Peluffo-Ordoñez

Current neuroimaging techniques provide paths to investigate the structure and function of the brain in vivo and have made great advances in understanding Alzheimer's disease (AD). However, the group-level analyses prevalently used for…

Quantitative Methods · Quantitative Biology 2021-05-31 Nanyan Zhu , Chen Liu , Xinyang Feng , Dipika Sikka , Sabrina Gjerswold-Selleck , Scott A. Small , Jia Guo

Early and accurate diagnosis of Alzheimer's disease (AD) and its prodromal period mild cognitive impairment (MCI) is essential for the delayed disease progression and the improved quality of patients'life. The emerging computer-aided…

Image and Video Processing · Electrical Eng. & Systems 2021-07-29 Fan Zhang , Bo Pan , Pengfei Shao , Peng Liu , Shuwei Shen , Peng Yao , Ronald X. Xu

Dementia, a prevalent neurodegenerative condition, is a major manifestation of Alzheimer's disease (AD). As the condition progresses from mild to severe, it significantly impairs the individual's ability to perform daily tasks…

Machine Learning · Computer Science 2023-11-06 Md Gulzar Hussain , Ye Shiren

Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to…

Alzheimer's Disease (AD) causes a continuous decline in memory, thinking, and judgment. Traditional diagnoses are usually based on clinical experience, which is limited by some realistic factors. In this paper, we focus on exploiting deep…

Image and Video Processing · Electrical Eng. & Systems 2023-03-14 Fangyu Zuo , Peiguang Jing , Jinglin Sun , Jizhong , Duan , Yong Ji , Yu Liu

Alzheimer's disease (AD) has a complex and multifactorial etiology, which requires integrating information about neuroanatomy, genetics, and cerebrospinal fluid biomarkers for accurate diagnosis. Hence, recent deep learning approaches…

Machine Learning · Computer Science 2023-03-15 Tom Nuno Wolf , Sebastian Pölsterl , Christian Wachinger

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, structural brain changes, and genetic predispositions. This study leverages machine-learning and statistical techniques to investigate…

Applications · Statistics 2025-10-29 Riddhik Basu , Arkaprava Roy