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Drug discovery frequently loses momentum when data, expertise, and tools are scattered, slowing design cycles. To shorten this loop we built a hierarchical, tool using agent framework that automates molecular optimisation. A Principal…

Machine Learning · Computer Science 2025-08-06 Atabey Ünlü , Phil Rohr , Ahmet Celebi

Complex chemical space and limited knowledge scope with biases holds immense challenge for human scientists, yet in automated materials discovery. Existing intelligent methods relies more on numerical computation, leading to inefficient…

Machine Learning · Computer Science 2025-04-15 Zheyuan Lai , Yingming Pu

Tool-augmented large language model (LLM) agents promise to unify scientific reasoning with computation, yet their deployment in high-stakes domains like drug discovery is bottlenecked by two critical barriers: unconstrained tool-use…

Artificial Intelligence · Computer Science 2026-03-05 He Cao , Siyu Liu , Fan Zhang , Zijing Liu , Hao Li , Bin Feng , Shengyuan Bai , Leqing Chen , Kai Xie , Yu Li

Large language models (LLMs) can reshape information processing by handling data analysis, visualization, and interpretation in an interactive, context-aware dialogue with users, including voice interaction, while maintaining high…

Artificial Intelligence · Computer Science 2025-11-25 Mohammad Nour Al Awad , Sergey Ivanov , Olga Tikhonova , Ivan Khodnenko

Multi-agent systems built on large language models (LLMs) require many coordination choices that are difficult to fix a priori: which skill protocol to invoke, which agent role should perform a subtask, which model to bind to each role, how…

Multiagent Systems · Computer Science 2026-05-28 Nicole Koenigstein

Large language models (LLMs) have proven effective in artificial intelligence, where the multi-agent system (MAS) holds considerable promise for healthcare development by achieving the collaboration of LLMs. However, the absence of a…

Artificial Intelligence · Computer Science 2026-05-13 Zhihao Peng , Liuxin Bao , Yixuan Yuan

Automating scientific computing workflows requires more than generating executable code: autonomous systems must also select appropriate computational strategies, implement them faithfully, and ensure that the resulting outcomes remain…

Artificial Intelligence · Computer Science 2026-05-29 Geremy Loachamín-Suntaxi , Robert Lazar , Dimitrios G. Giovanis , Ioannis G. Kevrekidis , Eleni D. Koronaki

The training of large multimodal models fundamentally relies on massive image-text datasets, which inevitably incur prohibitive computational overhead. Dataset selection offers a promising paradigm by identifying a highly informative…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Boran Zhao , Hetian Liu , Zhenxian Hu , Yuqing Yuan , Yu Yan , Pengju Ren

A multi-agent AI model is used to automate the discovery of new metallic alloys, integrating multimodal data and external knowledge including insights from physics via atomistic simulations. Our multi-agent system features three key…

Materials Science · Physics 2024-10-18 Alireza Ghafarollahi , Markus J. Buehler

This paper presents a Large Language Model (LLM) based conversational agent system designed to enhance human-machine collaboration in Machine Learning Operations (MLOps). We introduce the Swarm Agent, an extensible architecture that…

Artificial Intelligence · Computer Science 2025-11-11 George Fatouros , Georgios Makridis , George Kousiouris , John Soldatos , Anargyros Tsadimas , Dimosthenis Kyriazis

Current document chunking methods for Retrieval-Augmented Generation (RAG) typically linearize text. This forced linearization strips away intrinsic topological hierarchies, creating ``semantic fragmentation'' that degrades downstream…

Computation and Language · Computer Science 2026-03-20 Xiaoyu Liu

Multi-agent systems (MAS) based on large language models (LLMs) have demonstrated significant potential in collaborative problem-solving. However, they still face substantial challenges of low communication efficiency and suboptimal task…

Computation and Language · Computer Science 2025-03-25 Zhexuan Wang , Yutong Wang , Xuebo Liu , Liang Ding , Miao Zhang , Jie Liu , Min Zhang

High-quality quadrilateral mesh generation is a fundamental challenge in computer graphics. Traditional optimization-based methods are often constrained by the topological quality of input meshes and suffer from severe efficiency…

Graphics · Computer Science 2026-03-12 Yuguang Chen , Xinhai Liu , Xiangyu Zhu , Yiling Zhu , Zhuo Chen , Dongyu Zhang , Chunchao Guo

Large-scale electrification is vital to addressing the climate crisis, but several scientific and technological challenges remain to fully electrify both the chemical industry and transportation. In both of these areas, new electrochemical…

The synthesis of inorganic crystalline materials is essential for modern technology, especially in quantum materials development. However, designing efficient synthesis workflows remains a significant challenge due to the precise…

The advent of material databases provides an unprecedented opportunity to uncover predictive descriptors for emergent material properties from vast data space. However, common reliance on high-throughput ab initio data necessarily inherits…

To fully expedite AI-powered chemical research, high-quality chemical databases are the foundation. Automatic extraction of chemical information from the literature is essential for constructing reaction databases, but it is currently…

Artificial Intelligence · Computer Science 2026-03-09 Yufan Chen , Ching Ting Leung , Bowen Yu , Jianwei Sun , Yong Huang , Linyan Li , Hao Chen , Hanyu Gao

High-fidelity 3D head generation plays a crucial role in the film, animation and video game industries. In industrial pipelines, studios typically enforce a fixed reference topology across all head assets, as such a clean and uniform…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Bojun Xiong , Zoubin Bi , Xinghui Peng , Yunmu Wang , Junchen Deng , Jun Liang , Jing Li , Bowen Cai , Huan Fu

In enterprise datasets, documents are rarely pure. They are not just text, nor just numbers; they are a complex amalgam of narrative and structure. Current Retrieval-Augmented Generation (RAG) systems have attempted to address this…

Artificial Intelligence · Computer Science 2026-01-16 Alex Dantart , Marco Kóvacs-Navarro

The theory of symmetry indicators has enabled database searches for topological materials in normal conducting phases, which has led to several encyclopedic topological material databases. To date, such a database for topological…

Superconductivity · Physics 2022-07-07 Feng Tang , Seishiro Ono , Xiangang Wan , Haruki Watanabe