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Multimodal Large Language Models (MLLMs) have demonstrated remarkable potential in medical image analysis. However, their application in gastrointestinal endoscopy is currently hindered by two critical limitations: the misalignment between…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Huan Zheng , Yucheng Zhou , Tianyi Yan , Dubing Chen , Hongbo Lu , Wenlong Liao , Tao He , Pai Peng , Jianbing Shen

Large Language Models (LLMs) have transformed natural language processing and hold growing promise for advancing science, healthcare, and decision-making. Yet their training paradigms remain dominated by affirmation-based inference, akin to…

Artificial Intelligence · Computer Science 2025-12-05 Peter B. Walker , Hannah Davidson , Aiden Foster , Matthew Lienert , Thomas Pardue , Dale Russell

With the development of Deep Neural Networks (DNNs), many efforts have been made to handle medical image segmentation. Traditional methods such as nnUNet train specific segmentation models on the individual datasets. Plenty of recent…

Computer Vision and Pattern Recognition · Computer Science 2024-07-12 Xiaobao Wei , Jiajun Cao , Yizhu Jin , Ming Lu , Guangyu Wang , Shanghang Zhang

Automated segmentation is a fundamental medical image analysis task, which enjoys significant advances due to the advent of deep learning. While foundation models have been useful in natural language processing and some vision tasks for…

Computer Vision and Pattern Recognition · Computer Science 2025-05-12 Hanxue Gu , Haoyu Dong , Jichen Yang , Maciej A. Mazurowski

Causal reasoning capability is critical in advancing large language models (LLMs) toward strong artificial intelligence. While versatile LLMs appear to have demonstrated capabilities in understanding contextual causality and providing…

Artificial Intelligence · Computer Science 2025-06-30 Haoang Chi , He Li , Wenjing Yang , Feng Liu , Long Lan , Xiaoguang Ren , Tongliang Liu , Bo Han

Causal discovery aims to estimate causal structures among variables based on observational data. Large Language Models (LLMs) offer a fresh perspective to tackle the causal discovery problem by reasoning on the metadata associated with…

Computation and Language · Computer Science 2024-07-31 Yuni Susanti , Michael Färber

Vision-Language Models (VLMs) have enabled interpretable medical diagnosis by integrating visual perception with linguistic reasoning. Yet, existing medical chain-of-thought (CoT) models lack explicit mechanisms to represent and enforce…

Artificial Intelligence · Computer Science 2026-05-29 Jianxin Lin , Chunzheng Zhu , Peter J. Kneuertz , Yunfei Bai , Yuan Xue

Scaling laws have allowed Pre-trained Language Models (PLMs) into the field of causal reasoning. Causal reasoning of PLM relies solely on text-based descriptions, in contrast to causal discovery which aims to determine the causal…

This study evaluates causal reasoning in large language models (LLMs) using 99 clinically grounded laboratory test scenarios aligned with Pearl's Ladder of Causation: association, intervention, and counterfactual reasoning. We examined…

Artificial Intelligence · Computer Science 2025-09-23 Balu Bhasuran , Mattia Prosperi , Karim Hanna , John Petrilli , Caretia JeLayne Washington , Zhe He

Deep learning (DL) models for disease classification or segmentation from medical images are increasingly trained using transfer learning (TL) from unrelated natural world images. However, shortcomings and utility of TL for specialized…

Machine Learning · Statistics 2021-11-11 Sambuddha Ghosal , Pratik Shah

With the advancement of Large Language Model (LLM) for natural language processing, this paper presents an intriguing finding: a frozen pre-trained LLM layer can process visual tokens for medical image segmentation tasks. Specifically, we…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Fenghe Tang , Wenxin Ma , Zhiyang He , Xiaodong Tao , Zihang Jiang , S. Kevin Zhou

Large Language Models (LLMs) have emerged as powerful candidates to inform clinical decision-making processes. While these models play an increasingly prominent role in shaping the digital landscape, two growing concerns emerge in…

Computation and Language · Computer Science 2024-04-24 Raphael Poulain , Hamed Fayyaz , Rahmatollah Beheshti

Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models trained for a specific task. Training such models…

Image and Video Processing · Electrical Eng. & Systems 2025-12-18 Anwai Archit , Luca Freckmann , Constantin Pape

This work aligns deep learning (DL) with human reasoning capabilities and needs to enable more efficient, interpretable, and robust image classification. We approach this from three perspectives: explainability, causality, and biological…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Gianluca Carloni

Recent claims of strong performance by Large Language Models (LLMs) on causal discovery are undermined by a key flaw: many evaluations rely on benchmarks likely included in pretraining corpora. Thus, apparent success suggests that LLM-only…

The ability to robustly identify causal relationships is essential for autonomous decision-making and adaptation to novel scenarios. However, accurately inferring causal structure requires integrating both world knowledge and abstract…

Machine Learning · Computer Science 2025-06-17 Khurram Yamin , Shantanu Gupta , Gaurav R. Ghosal , Zachary C. Lipton , Bryan Wilder

Building causal graphs can be a laborious process. To ensure all relevant causal pathways have been captured, researchers often have to discuss with clinicians and experts while also reviewing extensive relevant medical literature. By…

Computation and Language · Computer Science 2024-02-26 Stephanie Long , Tibor Schuster , Alexandre Piché

Large Language Models (LLMs) have fundamentally reshaped Argument Mining (AM), shifting it from a pipeline of supervised, task-specific classifiers to a spectrum of prompt-driven, retrieval-augmented, and reasoning-oriented paradigms. Yet…

Computation and Language · Computer Science 2025-11-26 Hao Li , Viktor Schlegel , Yizheng Sun , Riza Batista-Navarro , Goran Nenadic

Structured data offers a sophisticated mechanism for the organization of information. Existing methodologies for the text-serialization of structured data in the context of large language models fail to adequately address the heterogeneity…

Computation and Language · Computer Science 2024-02-20 YiQiu Guo , Yuchen Yang , Ya Zhang , Yu Wang , Yanfeng Wang

Pre-trained language models based on masked language modeling (MLM) excel in natural language understanding (NLU) tasks. While fine-tuned MLM-based encoders consistently outperform causal language modeling decoders of comparable size,…

Computation and Language · Computer Science 2024-06-07 David Dukić , Jan Šnajder