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Histological staining of tissue biopsies, especially hematoxylin and eosin (H&E) staining, serves as the benchmark for disease diagnosis and comprehensive clinical assessment of tissue. However, the process is laborious and time-consuming,…

The application of machine learning techniques to the medical domain is especially challenging due to the required level of precision and the incurrence of huge risks of minute errors. Employing these techniques to a more complex subdomain…

Computer Vision and Pattern Recognition · Computer Science 2021-10-19 Ekta Gavas , Kaustubh Olpadkar

Digital Pathology is a cornerstone in the diagnosis and treatment of diseases. A key task in this field is the identification and segmentation of cells in hematoxylin and eosin-stained images. Existing methods for cell segmentation often…

Computer Vision and Pattern Recognition · Computer Science 2025-01-10 Fabian Hörst , Moritz Rempe , Helmut Becker , Lukas Heine , Julius Keyl , Jens Kleesiek

Machine learning-based modeling of physical systems has experienced increased interest in recent years. Despite some impressive progress, there is still a lack of benchmarks for Scientific ML that are easy to use but still challenging and…

We introduce a unified benchmarking framework focused on evaluating EEG-based foundation models in clinical applications. The benchmark spans 11 well-defined diagnostic tasks across 14 publicly available EEG datasets, including epilepsy,…

Machine Learning · Computer Science 2025-12-11 Ard Kastrati , Josua Bürki , Jonas Lauer , Cheng Xuan , Raffaele Iaquinto , Roger Wattenhofer

The production of food, feed, fiber, and fuel is a key task of agriculture, which has to cope with many challenges in the upcoming decades, e.g., a higher demand, climate change, lack of workers, and the availability of arable land. Vision…

Computer Vision and Pattern Recognition · Computer Science 2024-07-25 Jan Weyler , Federico Magistri , Elias Marks , Yue Linn Chong , Matteo Sodano , Gianmarco Roggiolani , Nived Chebrolu , Cyrill Stachniss , Jens Behley

Cancer research is increasingly driven by the integration of diverse data modalities, spanning from genomics and proteomics to imaging and clinical factors. However, extracting actionable insights from these vast and heterogeneous datasets…

Deep learning models can generate virtual immunohistochemistry (IHC) stains from hematoxylin and eosin (H&E) images, offering a scalable and low-cost alternative to laboratory IHC. However, reliable evaluation of image quality remains a…

Computer Vision and Pattern Recognition · Computer Science 2025-11-07 Tushar Kataria , Shikha Dubey , Mary Bronner , Jolanta Jedrzkiewicz , Ben J. Brintz , Shireen Y. Elhabian , Beatrice S. Knudsen

Automatic detection of lymphocyte in H&E images is a necessary first step in lots of tissue image analysis algorithms. An accurate and robust automated lymphocyte detection approach is of great importance in both computer science and…

Computer Vision and Pattern Recognition · Computer Science 2016-12-13 Jianxu Chen , Chukka Srinivas

We present a method for automatic cell classification in tissue samples using an automated training set from multiplexed immunofluorescence images. The method utilizes multiple markers stained in situ on a single tissue section on a robust…

Image and Video Processing · Electrical Eng. & Systems 2020-07-21 Alberto Santamaria-Pang , Anup Sood , Dan Meyer , Aritra Chowdhury , Fiona Ginty

Whole slide image (WSI) analysis has emerged as an increasingly essential technique in computational pathology. Recent advances in the pathology foundation models (FMs) have demonstrated significant advantages in deriving meaningful…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Zhidong Yang , Xiuhui Shi , Wei Ba , Zhigang Song , Haijing Luan , Taiyuan Hu , Senlin Lin , Jiguang Wang , Shaohua Kevin Zhou , Rui Yan

Breast cancer is a leading cause of cancer-related mortality worldwide, and timely accurate diagnosis is critical to improving survival outcomes. While convolutional neural networks (CNNs) have demonstrated strong performance on…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Aditya Shribhagwan Khandelwal , Mohammad Samar Ansari , Asra Aslam

Hematoxylin and eosin (H&E) staining is the clinical standard for assessing tissue morphology, but it lacks molecular-level diagnostic information. In contrast, immunohistochemistry (IHC) provides crucial insights into biomarker expression,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Jingsong Liu , Xiaofeng Deng , Han Li , Azar Kazemi , Christian Grashei , Gesa Wilkens , Xin You , Tanja Groll , Nassir Navab , Carolin Mogler , Peter J. Schüffler

Progress in a research field can be hard to assess, in particular when many concurrent methods are proposed in a short period of time. This is the case in digital pathology, where many foundation models have been released recently to serve…

Computer Vision and Pattern Recognition · Computer Science 2026-02-18 Pierre Marza , Leo Fillioux , Sofiène Boutaj , Kunal Mahatha , Christian Desrosiers , Pablo Piantanida , Jose Dolz , Stergios Christodoulidis , Maria Vakalopoulou

Hematoxylin and eosin (H&E) staining visualizes histology but lacks specificity for diagnostic markers. Immunohistochemistry (IHC) staining provides protein-targeted staining but is restricted by tissue availability and antibody…

Image and Video Processing · Electrical Eng. & Systems 2025-07-01 Anran Liu , Xiaofei Wang , Jing Cai , Chao Li

Over the past decade, generative models have demonstrated success in enhancing fundus images. However, the evaluation of these models remains a challenge. A benchmark for fundus image enhancement is needed for three main reasons:(1)…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Xuanzhao Dong , Wenhui Zhu , Xiwen Chen , Hao Wang , Xin Li , Yujian Xiong , Jiajun Cheng , Zhipeng Wang , Shao Tang , Oana Dumitrascu , Yalin Wang

We present ASCENDgpt, a transformer-based model specifically designed for cardiovascular risk prediction from longitudinal electronic health records (EHRs). Our approach introduces a novel phenotype-aware tokenization scheme that maps…

Computation and Language · Computer Science 2025-09-08 Chris Sainsbury , Andreas Karwath

Immunohistochemistry (IHC) plays a crucial role in pathology as it detects the over-expression of protein in tissue samples. However, there are still fewer machine learning model studies on IHC's impact on accurate cancer grading. We…

Computer Vision and Pattern Recognition · Computer Science 2024-05-15 Jun Wang , Yu Mao , Yufei Cui , Nan Guan , Chun Jason Xue

Foundation models and vision-language pre-training have significantly advanced Vision-Language Models (VLMs), enabling multimodal processing of visual and linguistic data. However, their application in domain-specific agricultural tasks,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-23 Khang Nguyen Quoc , Phuong D. Dao , Luyl-Da Quach

Electronic Health Records are electronic data generated during or as a byproduct of routine patient care. Structured, semi-structured and unstructured EHR offer researchers unprecedented phenotypic breadth and depth and have the potential…

Artificial Intelligence · Computer Science 2017-07-26 Vaclav Papez , Spiros Denaxas , Harry Hemingway
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