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$\textbf{Objectives}$: Large Language Models (LLMs) such as ChatGPT and Med-PaLM have excelled in various medical question-answering tasks. However, these English-centric models encounter challenges in non-English clinical settings,…

Computation and Language · Computer Science 2024-01-31 Jiageng Wu , Xian Wu , Zhaopeng Qiu , Minghui Li , Yingying Zhang , Yefeng Zheng , Changzheng Yuan , Jie Yang

Matching patients to clinical trials is a key unsolved challenge in bringing new drugs to market. Today, identifying patients who meet a trial's eligibility criteria is highly manual, taking up to 1 hour per patient. Automated screening is…

Computation and Language · Computer Science 2024-04-11 Michael Wornow , Alejandro Lozano , Dev Dash , Jenelle Jindal , Kenneth W. Mahaffey , Nigam H. Shah

Large language models (LLMs) have demonstrated remarkable capabilities in natural language understanding and generation across various domains, including medicine. We present a comprehensive evaluation of GPT-4, a state-of-the-art LLM, on…

Computation and Language · Computer Science 2023-04-13 Harsha Nori , Nicholas King , Scott Mayer McKinney , Dean Carignan , Eric Horvitz

In practice, clinicians achieve a diagnosis by following a sequence of steps, such as laboratory exams, observations, or imaging. The pathways to reach diagnosis decisions are documented by guidelines authored by expert organizations, which…

Computation and Language · Computer Science 2024-09-25 Elisa Castagnari , Lillian Muyama , Adrien Coulet

Biomedical literature often uses complex language and inaccessible professional terminologies. That is why simplification plays an important role in improving public health literacy. Applying Natural Language Processing (NLP) models to…

Computation and Language · Computer Science 2024-03-19 Zihao Li , Samuel Belkadi , Nicolo Micheletti , Lifeng Han , Matthew Shardlow , Goran Nenadic

Large language models (LLMs) are effective at capturing complex, valuable conceptual representations from textual data for a wide range of real-world applications. However, in fields like Intelligent Fault Diagnosis (IFD), incorporating…

Artificial Intelligence · Computer Science 2024-12-03 Hamzah A. A. M. Qaid , Bo Zhang , Dan Li , See-Kiong Ng , Wei Li

Data imputation is a cornerstone technique for handling missing values in real-world datasets, which are often plagued by missingness. Despite recent progress, prior studies on Large Language Models-based imputation remain limited by…

Machine Learning · Computer Science 2026-03-25 Arthur Dantas Mangussi , Ricardo Cardoso Pereira , Ana Carolina Lorena , Pedro Henriques Abreu

Multimodal large language models (MLLMs) represent an evolutionary expansion in the capabilities of traditional large language models, enabling them to tackle challenges that surpass the scope of purely text-based applications. It leverages…

Computation and Language · Computer Science 2025-01-17 Jinlong He , Pengfei Li , Gang Liu , Genrong He , Zhaolin Chen , Shenjun Zhong

Clinical trial matching is a key process in health delivery and discovery. In practice, it is plagued by overwhelming unstructured data and unscalable manual processing. In this paper, we conduct a systematic study on scaling clinical trial…

This study evaluates the performance of large language models (LLMs) and the HINT model in predicting clinical trial outcomes, focusing on metrics including Balanced Accuracy, Matthews Correlation Coefficient (MCC), Recall, and Specificity.…

Machine Learning · Computer Science 2025-03-19 Shuyi Jin , Lu Chen , Hongru Ding , Meijie Wang , Lun Yu

Large Language Models (LLMs) pre-trained on multilingual data have revolutionized natural language processing research, by transitioning from languages and task specific model pipelines to a single model adapted on a variety of tasks.…

Computation and Language · Computer Science 2025-01-31 Munief Hassan Tahir , Sana Shams , Layba Fiaz , Farah Adeeba , Sarmad Hussain

The immense computational cost of training Large Language Models (LLMs) presents a major barrier to innovation. While FP8 training offers a promising solution with significant theoretical efficiency gains, its widespread adoption has been…

Computation and Language · Computer Science 2025-10-20 Wenjun Wang , Shuo Cai , Congkai Xie , Mingfa Feng , Yiming Zhang , Zhen Li , Kejing Yang , Ming Li , Jiannong Cao , Hongxia Yang

The implementation of Artificial Intelligence (AI) in the healthcare industry has garnered considerable attention, attributable to its prospective enhancement of clinical outcomes, expansion of access to superior healthcare, cost reduction,…

Computation and Language · Computer Science 2024-08-23 Arindam Sett , Somaye Hashemifar , Mrunal Yadav , Yogesh Pandit , Mohsen Hejrati

Large Language Models (LLMs) recently achieved great success in medical text summarization by simply using in-context learning. However, these recent efforts do not perform fine-grained evaluations under difficult settings where LLMs might…

Computation and Language · Computer Science 2026-04-22 Gunjan Balde , Soumyadeep Roy , Mainack Mondal , Niloy Ganguly

The performance of deep learning-based natural language processing systems is based on large amounts of labeled training data which, in the clinical domain, are not easily available or affordable. Weak supervision and in-context learning…

Computation and Language · Computer Science 2025-04-02 Enshuo Hsu , Kirk Roberts

Large language models (LLMs) have shown remarkable capabilities in Natural Language Processing (NLP), especially in domains where labeled data is scarce or expensive, such as clinical domain. However, to unlock the clinical knowledge hidden…

Computation and Language · Computer Science 2023-09-18 Sonish Sivarajkumar , Mark Kelley , Alyssa Samolyk-Mazzanti , Shyam Visweswaran , Yanshan Wang

Instruction-finetuning (IFT) has become crucial in aligning Large Language Models (LLMs) with diverse human needs and has shown great potential in medical applications. However, previous studies mainly fine-tune LLMs on biomedical datasets…

Computation and Language · Computer Science 2025-04-02 Xinlu Zhang , Chenxin Tian , Xianjun Yang , Lichang Chen , Zekun Li , Linda Ruth Petzold

Improving the accuracy and reliability of medical coding reduces clinician burnout and supports revenue cycle processes, freeing providers to focus more on patient care. However, automating the assignment of ICD-10-CM and CPT codes from…

Mental health disorders pose a growing public health concern in the Arab world, emphasizing the need for accessible diagnostic and intervention tools. Large language models (LLMs) offer a promising approach, but their application in Arabic…

Computation and Language · Computer Science 2025-01-14 Noureldin Zahran , Aya E. Fouda , Radwa J. Hanafy , Mohammed E. Fouda
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