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We introduce Spectral Guidance, a framework for controlling diffusion models by leveraging the intrinsic geometry of the generative process. As data is progressively corrupted by noise, only a small number of features remain informative for…

Machine Learning · Computer Science 2026-05-29 Gabriel Moreira , Manuel Marques , João Paulo Costeira , Chenyan Xiong

Deep neural networks have brought remarkable breakthroughs in medical image analysis. However, due to their data-hungry nature, the modest dataset sizes in medical imaging projects might be hindering their full potential. Generating…

Diffusion MRI (dMRI) is an advanced imaging technique characterizing tissue microstructure and white matter structural connectivity of the human brain. The demand for high-quality dMRI data is growing, driven by the need for better…

Image and Video Processing · Electrical Eng. & Systems 2024-08-26 Xi Zhu , Wei Zhang , Yijie Li , Lauren J. O'Donnell , Fan Zhang

Score-based diffusion modeling is a generative machine learning algorithm that can be used to sample from complex distributions. They achieve this by learning a score function, i.e., the gradient of the log-probability density of the data,…

Machine Learning · Computer Science 2025-12-17 Dibyajyoti Chakraborty , Haiwen Guan , Jason Stock , Troy Arcomano , Guido Cervone , Romit Maulik

Modern successes of diffusion models in learning complex, high-dimensional data distributions are attributed, in part, to their capability to construct diffusion processes with analytic transition kernels and score functions. The…

Machine Learning · Statistics 2024-03-01 Guan-Horng Liu , Tianrong Chen , Evangelos A. Theodorou , Molei Tao

In this paper we describe a novel framework for diffusion-based generative modeling on constrained spaces. In particular, we introduce manual bridges, a framework that expands the kinds of constraints that can be practically used to form…

Machine Learning · Computer Science 2025-02-28 Saeid Naderiparizi , Xiaoxuan Liang , Berend Zwartsenberg , Frank Wood

Diffusion Models represent a significant advancement in generative modeling, employing a dual-phase process that first degrades domain-specific information via Gaussian noise and restores it through a trainable model. This framework enables…

Neural and Evolutionary Computing · Computer Science 2024-11-21 Benedikt Hartl , Yanbo Zhang , Hananel Hazan , Michael Levin

Generative models have the potential to accelerate key steps in the discovery of novel molecular therapeutics and materials. Diffusion models have recently emerged as a powerful approach, excelling at unconditional sample generation and,…

Biomolecules · Quantitative Biology 2024-07-17 Leo Klarner , Tim G. J. Rudner , Garrett M. Morris , Charlotte M. Deane , Yee Whye Teh

Along with the prosperity of generative artificial intelligence (AI), its potential for solving conventional challenges in wireless communications has also surfaced. Inspired by this trend, we investigate the application of the advanced…

Information Theory · Computer Science 2026-03-10 Xingyu Zhou , Le Liang , Jing Zhang , Peiwen Jiang , Yong Li , Shi Jin

Variable selection for high-dimensional, highly correlated data has long been a challenging problem, often yielding unstable and unreliable models. We propose a resample-aggregate framework that exploits diffusion models' ability to…

Methodology · Statistics 2025-08-20 Minjie Wang , Xiaotong Shen , Wei Pan

Recent text-to-image generation favors various forms of spatial conditions, e.g., masks, bounding boxes, and key points. However, the majority of the prior art requires form-specific annotations to fine-tune the original model, leading to…

Computer Vision and Pattern Recognition · Computer Science 2025-01-03 Z. Zhang , B. Liu , J. Bao , L. Chen , S. Zhu , J. Yu

Diffusion based generative models have achieved unprecedented fidelity in synthesizing high dimensional data, yet the theoretical mechanisms governing multimodal generation remain poorly understood. Here, we present a theoretical framework…

Machine Learning · Computer Science 2026-02-10 Emil Albrychiewicz , Andrés Franco Valiente , Li-Ching Chen

Diffusion models (DMs) represent state-of-the-art generative models for continuous inputs. DMs work by constructing a Stochastic Differential Equation (SDE) in the input space (ie, position space), and using a neural network to reverse it.…

Machine Learning · Computer Science 2024-05-14 Tianrong Chen , Jiatao Gu , Laurent Dinh , Evangelos A. Theodorou , Joshua Susskind , Shuangfei Zhai

The controllable generation of diffusion models aims to steer the model to generate samples that optimize some given objective functions. It is desirable for a variety of applications including image generation, molecule generation, and…

Machine Learning · Computer Science 2025-05-29 Owen Oertell , Shikun Sun , Yiding Chen , Jin Peng Zhou , Zhiyong Wang , Wen Sun

We present a data-driven method for learning to generate animations of 3D garments using a 2D image diffusion model. In contrast to existing methods, typically based on fully connected networks, graph neural networks, or generative…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Raquel Vidaurre , Elena Garces , Dan Casas

Beyond estimating parameters of interest from data, one of the key goals of statistical inference is to properly quantify uncertainty in these estimates. In Bayesian inference, this uncertainty is provided by the posterior distribution, the…

Machine Learning · Computer Science 2025-01-03 Daniela de Albuquerque , John Pearson

Incomplete data are common in real-world tabular applications, where numerical, categorical, and discrete attributes coexist within a single dataset. This heterogeneous structure presents significant challenges for existing diffusion-based…

Machine Learning · Computer Science 2025-11-19 Youran Zhou , Mohamed Reda Bouadjenek , Sunil Aryal

Conditional image synthesis based on user-specified requirements is a key component in creating complex visual content. In recent years, diffusion-based generative modeling has become a highly effective way for conditional image synthesis,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Zheyuan Zhan , Defang Chen , Jian-Ping Mei , Zhenghe Zhao , Jiawei Chen , Chun Chen , Siwei Lyu , Can Wang

This tutorial provides an in-depth guide on inference-time guidance and alignment methods for optimizing downstream reward functions in diffusion models. While diffusion models are renowned for their generative modeling capabilities,…

Artificial Intelligence · Computer Science 2025-01-22 Masatoshi Uehara , Yulai Zhao , Chenyu Wang , Xiner Li , Aviv Regev , Sergey Levine , Tommaso Biancalani

The emergence of generative models has revolutionized the field of remote sensing (RS) image generation. Despite generating high-quality images, existing methods are limited in relying mainly on text control conditions, and thus do not…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Datao Tang , Xiangyong Cao , Xingsong Hou , Zhongyuan Jiang , Junmin Liu , Deyu Meng
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