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Over the past decade, the use of machine learning (ML) models in healthcare applications has rapidly increased. Despite high performance, modern ML models do not always capture patterns the end user requires. For example, a model may…

The generalization performance of a risk prediction model can be evaluated by its calibration, which measures the agreement between predicted and observed outcomes on external validation data. Here, methods for assessing the calibration of…

Methodology · Statistics 2020-01-31 Moritz Berger , Matthias Schmid

Covariate adjustment aims to improve the statistical efficiency of randomized trials by incorporating information from baseline covariates. Popular methods for covariate adjustment include analysis of covariance for continuous endpoints and…

Methodology · Statistics 2025-05-09 Zhiwei Zhang , Ya Wang , Dong Xi

Survival models are a popular tool for the analysis of time to event data with applications in medicine, engineering, economics, and many more. Advances like the Cox proportional hazard model have enabled researchers to better describe…

Machine Learning · Statistics 2021-02-16 Stefan Groha , Sebastian M Schmon , Alexander Gusev

Optimization in machine learning typically deals with the minimization of empirical objectives defined by training data. However, the ultimate goal of learning is to minimize the error on future data (test error), for which the training…

Machine Learning · Statistics 2021-11-08 Bernhard Stankewitz , Nicole Mücke , Lorenzo Rosasco

Continual Learning (CL) focuses on maximizing the predictive performance of a model across a non-stationary stream of data. Unfortunately, CL models tend to forget previous knowledge, thus often underperforming when compared with an offline…

Machine Learning · Computer Science 2024-04-15 Lanpei Li , Elia Piccoli , Andrea Cossu , Davide Bacciu , Vincenzo Lomonaco

In this paper, we present a new way of matching in observational studies that overcomes three limitations of existing matching approaches. First, it directly balances covariates with multi-valued treatments without requiring the generalized…

Applications · Statistics 2019-07-11 Magdalena Bennett , Juan Pablo Vielma , Jose R. Zubizarreta

Model regularization requires extensive manual tuning to balance complexity against overfitting. Cross-regularization resolves this tradeoff by directly adapting regularization parameters through validation gradients during training. The…

Machine Learning · Computer Science 2025-06-25 Carlos Stein Brito

Multilingual models are parameter-efficient and especially effective in improving low-resource languages by leveraging crosslingual transfer. Despite recent advance in massive multilingual translation with ever-growing model and data, how…

Computation and Language · Computer Science 2021-12-01 Xian Li , Hongyu Gong

The decision to incorporate cross-validation into validation processes of mathematical models raises an immediate question - how should one partition the data into calibration and validation sets? We answer this question systematically: we…

Data Analysis, Statistics and Probability · Physics 2011-08-31 Rebecca Morrison , Corey Bryant , Gabriel Terejanu , Kenji Miki , Serge Prudhomme

Survival analysis is crucial for many medical applications, but remains challenging for modern machine learning due to limited data, censoring, and the heterogeneity of tabular covariates. While the prior-fitted paradigm, which relies on…

Machine Learning · Computer Science 2026-05-14 Dmitrii Seletkov , Paul Hager , Georgios Kaissis , Rickmer Braren , Daniel Rueckert , Raphael Rehms

Purpose: To describe and mathematically validate the superiorization methodology, which is a recently-developed heuristic approach to optimization, and to discuss its applicability to medical physics problem formulations that specify the…

Optimization and Control · Mathematics 2015-06-11 G. T. Herman , E. Garduño , R. Davidi , Y. Censor

We present a novel regularization approach to train neural networks that enjoys better generalization and test error than standard stochastic gradient descent. Our approach is based on the principles of cross-validation, where a validation…

Computer Vision and Pattern Recognition · Computer Science 2018-09-06 Simon Jenni , Paolo Favaro

Reliable confidence estimation for the predictions is important in many safety-critical applications. However, modern deep neural networks are often overconfident for their incorrect predictions. Recently, many calibration methods have been…

Machine Learning · Computer Science 2023-03-07 Fei Zhu , Zhen Cheng , Xu-Yao Zhang , Cheng-Lin Liu

A learning task, understood as the problem of fitting a parametric model from supervised data, fundamentally requires the dataset to be large enough to be representative of the underlying distribution of the source. When data is limited,…

Machine Learning · Computer Science 2025-11-18 Leopoldo Agorio , Juan Cerviño , Miguel Calvo-Fullana , Alejandro Ribeiro , Juan Andrés Bazerque

Survival analysis is a critical tool for modeling time-to-event data. Recent deep learning-based models have reduced various modeling assumptions including proportional hazard and linearity. However, a persistent challenge remains in…

Machine Learning · Computer Science 2025-12-30 Maxmillan Ries , Sohan Seth

Constrained clustering allows the training of classification models using pairwise constraints only, which are weak and relatively easy to mine, while still yielding full-supervision-level model performance. While they perform well even in…

Machine Learning · Computer Science 2023-11-28 Jann Goschenhofer , Bernd Bischl , Zsolt Kira

Multi-calibration is a powerful and evolving concept originating in the field of algorithmic fairness. For a predictor $f$ that estimates the outcome $y$ given covariates $x$, and for a function class $\mathcal{C}$, multi-calibration…

Machine Learning · Computer Science 2023-03-09 Zhun Deng , Cynthia Dwork , Linjun Zhang

Probabilistic survival predictions from models trained with Maximum Likelihood Estimation (MLE) can have high, and sometimes unacceptably high variance. The field of meteorology, where the paradigm of maximizing sharpness subject to…

Machine Learning · Computer Science 2019-06-20 Anand Avati , Tony Duan , Sharon Zhou , Kenneth Jung , Nigam H. Shah , Andrew Ng

Overconfidence and underconfidence in machine learning classifiers is measured by calibration: the degree to which the probabilities predicted for each class match the accuracy of the classifier on that prediction. How one measures…

Machine Learning · Computer Science 2020-08-11 Jeremy Nixon , Mike Dusenberry , Ghassen Jerfel , Timothy Nguyen , Jeremiah Liu , Linchuan Zhang , Dustin Tran