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Large language models (LLMs) have demonstrated impressive generative capabilities with the potential to innovate in medicine. However, the application of LLMs in real clinical settings remains challenging due to the lack of factual…

Computation and Language · Computer Science 2024-07-08 Rui Yang , Haoran Liu , Edison Marrese-Taylor , Qingcheng Zeng , Yu He Ke , Wanxin Li , Lechao Cheng , Qingyu Chen , James Caverlee , Yutaka Matsuo , Irene Li

Formulating a treatment plan is inherently a complex reasoning and refinement task rather than a simple generation problem. However, existing large language models (LLMs) mainly rely on one-shot output without explicit verification, which…

Artificial Intelligence · Computer Science 2026-05-08 Junkai Li , Yunghwei Lai , Tianyi Zhu , Zheng Long Lee , Weizhi Ma , Yang Liu

The rapid growth of biomedical knowledge has outpaced our ability to efficiently extract insights and generate novel hypotheses. Large language models (LLMs) have emerged as a promising tool to revolutionize knowledge interaction and…

Computation and Language · Computer Science 2024-07-16 Biqing Qi , Kaiyan Zhang , Kai Tian , Haoxiang Li , Zhang-Ren Chen , Sihang Zeng , Ermo Hua , Hu Jinfang , Bowen Zhou

Machine learning for tabular data remains constrained by poor schema generalization, a challenge rooted in the lack of semantic understanding of structured variables. This challenge is particularly acute in domains like clinical medicine,…

Machine Learning · Computer Science 2026-05-05 Hongxi Mao , Wei Zhou , Mengting Jia , Tao Fang , Huan Gao , Bin Zhang , Shangyang Li

Large Language Models (LLMs) have demonstrated remarkable capabilities in text generation and understanding, yet their reliance on implicit, unstructured knowledge often leads to factual inaccuracies and limited interpretability. Knowledge…

Computation and Language · Computer Science 2025-06-17 Qinggang Zhang

Clinical antimicrobial therapy requires the dynamic integration of pathogen profiles,host factors, pharmacological properties of antimicrobials,and the severity of infection. This complexity imposes fundamental limitations on the…

Artificial Intelligence · Computer Science 2025-11-27 Zhe Li , Yehan Qiu , Yujie Chen , Xiang Zhou

Large language models (LLMs) constitute a breakthrough state-of-the-art Artificial Intelligence technology which is rapidly evolving and promises to aid in medical diagnosis. However, the correctness and the accuracy of their returns has…

Computation and Language · Computer Science 2024-02-07 Dimitrios P. Panagoulias , Maria Virvou , George A. Tsihrintzis

Clinical decision-making depends on expert reasoning, which is guided by standardized, evidence-based guidelines. However, translating these guidelines into automated clinical decision support systems risks inaccuracy and importantly, loss…

Dermatological diagnosis requires integrating fine-grained visual perception with expert clinical knowledge. Although Multimodal Large Language Models (MLLMs) facilitate interactive medical image analysis, their application in dermatology…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Yize Liu , Siyuan Yan , Ming Hu , Lie Ju , Xieji Li , Feilong Tang , Wei Feng , Zongyuan Ge

Leveraging Large Language Models (LLMs) with Retrieval-Augmented Generation (RAG) for analyzing medical data, particularly Electrocardiogram (ECG), offers high accuracy and convenience. However, generating reliable, evidence-based results…

Machine Learning · Computer Science 2025-05-08 Jin Yu , JaeHo Park , TaeJun Park , Gyurin Kim , JiHyun Lee , Min Sung Lee , Joon-myoung Kwon , Jeong Min Son , Yong-Yeon Jo

Zero-shot reasoning methods with Large Language Models (LLMs) offer significant advantages including great generalization to novel tasks and reduced dependency on human-crafted examples. However, the current zero-shot methods still have…

Machine Learning · Computer Science 2024-10-28 Pengfei He , Zitao Li , Yue Xing , Yaling Li , Jiliang Tang , Bolin Ding

Answering complex medical questions requires not only domain expertise and patient-specific information, but also structured and multi-perspective reasoning. Existing multi-agent approaches often rely on fixed roles or shallow interaction…

Artificial Intelligence · Computer Science 2026-03-04 Siqi Ma , Jiajie Huang , Fan Zhang , Yue Shen , Jinlin Wu , Guohui Fan , Zhu Zhang , Zelin Zang

Large language models (LLMs) face challenges in solving complex mathematical problems that require comprehensive capacities to parse the statements, associate domain knowledge, perform compound logical reasoning, and integrate the…

Artificial Intelligence · Computer Science 2023-12-19 Haoran Liao , Qinyi Du , Shaohua Hu , Hao He , Yanyan Xu , Jidong Tian , Yaohui Jin

Large Language Models (LLMs) have demonstrated remarkable capabilities in natural language understanding and generation. However, they often struggle with complex reasoning tasks and are prone to hallucination. Recent research has shown…

Computation and Language · Computer Science 2024-12-17 Xue Wu , Kostas Tsioutsiouliklis

Large Language Models (LLMs) have exhibited impressive proficiency in various natural language processing (NLP) tasks, which involve increasingly complex reasoning. Knowledge reasoning, a primary type of reasoning, aims at deriving new…

Computation and Language · Computer Science 2024-07-02 Yifei Zhang , Xintao Wang , Jiaqing Liang , Sirui Xia , Lida Chen , Yanghua Xiao

Multi-hop reasoning is an effective approach for query answering (QA) over incomplete knowledge graphs (KGs). The problem can be formulated in a reinforcement learning (RL) setup, where a policy-based agent sequentially extends its…

Artificial Intelligence · Computer Science 2018-09-13 Xi Victoria Lin , Richard Socher , Caiming Xiong

Learning analytics systems increasingly integrate large language models (LLMs) to provide adaptive scaffolding in complex learning environments, yet personalization is often driven by global instructional choices rather than principled…

Human-Computer Interaction · Computer Science 2026-05-07 Fatma Betul Gures , Tanya Nazaretsky , Tanja Kaser

API recommendation methods have evolved from literal and semantic keyword matching to query expansion and query clarification. The latest query clarification method is knowledge graph (KG)-based, but limitations include out-of-vocabulary…

Software Engineering · Computer Science 2023-09-29 Qing Huang , Zhenyu Wan , Zhenchang Xing , Changjing Wang , Jieshan Chen , Xiwei Xu , Qinghua Lu

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Objective: Clinical documentation contains factual, diagnostic, and management errors that can compromise patient safety. Large language models (LLMs) may help detect and correct such errors, but their behavior under different prompting…

Computation and Language · Computer Science 2025-11-27 Farzad Ahmed , Joniel Augustine Jerome , Meliha Yetisgen , Özlem Uzuner