Related papers: A Multi-Scale Finite Element Method for Investigat…
Quantifying fiber disarray, which is a prominent maladaptation associated with hypertrophic cardiomyopathy, remains critical to understanding the disease's complex pathophysiology. This study investigates the role of heterogeneous…
A major challenge in computational models of cardiac electromechanics is the reconstruction of myocardial fiber architecture, as direct in vivo measurements of fiber orientation are not feasible. Consequently, rule-based methods are…
Atrial fibrillation (AF) increases the risk of stroke by a factor of four to five and is the most common abnormal heart rhythm. The progression of AF with age, from short self-terminating episodes to persistence, varies between individuals…
The structural and functional maturation of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is essential for application to pharmaceutical testing, disease modeling, and ultimately therapeutic use. Multicellular…
Hypertrophic cardiomyopathy (HCM) patients have a high incidence of atrial fibrillation (AF) and increased stroke risk, even with low risk of congestive heart failure, hypertension, age, diabetes, previous stroke/transient ischemic attack…
Deformation modeling of cardiac muscle is an important issue in the field of cardiac analysis. Many approaches have been developed to better estimate the cardiac muscle deformation, and to obtain a practical model to be used in diagnostic…
In cardiac cells, structural organization is an important indicator of cell maturity and healthy function. Healthy cardiomyocytes exhibit well-aligned morphology with densely packed and organized sarcomeres. Immature or diseased…
Deformation modeling of cardiac muscle is an important issue in the field of cardiac analysis. For this reason, many approaches have been developed to best estimate the cardiac muscle deformation, and to obtain a practical model to use in…
Cardiac deformation is a crucial biomarker for the evaluation of cardiac function. Current methods for estimating cardiac strain might underestimate local deformation due to through-plane motion and segmental averaging. Mesh-based mapping…
One of the challenges in the development of patient-specific models of cardiac arrhythmias for clinical applications has been accounting for myocardial fiber organization. The fiber varies significantly from heart to heart, but cannot be…
As the number of patients with heart failure increases, machine learning (ML) has garnered attention in cardiomyopathy diagnosis, driven by the shortage of pathologists. However, endomyocardial biopsy specimens are often small sample size…
Computational models in cardiac electrophysiology are notorious for long runtimes, restricting the numbers of nodes and mesh elements in the numerical discretisations used for their solution. This makes it particularly challenging to…
The contractile motion of the heart is strongly determined by the distribution of the fibers that constitute cardiac tissue. Strain analysis informed with the orientation of fibers allows to describe several pathologies that are typically…
The study of pathological cardiac conditions such as arrhythmias, a major cause of mortality in heart failure, is becoming increasingly informed by computational simulation, numerically modelling the governing equations. This can provide…
Understanding the biomechanics of the heart in health and disease plays an important role in the diagnosis and treatment of heart failure. The use of computational biomechanical models for therapy assessment is paving the way for…
Cardiopulmonary resuscitation (CPR) is an emergency procedure performed on patients during cardiac and respiratory arrest. This procedure externally activates the cardiac and respiratory systems via the delivery of chest compression and…
Cardiac growth and remodeling (G&R) patterns change ventricular size, shape, and function both globally and locally. Biomechanical, neurohormonal, and genetic stimuli drive these patterns through changes in myocyte dimension and fibrosis.…
In this paper we propose a novel coupled poroelasticity-diffusion model for the formation of extracellular oedema and infectious myocarditis valid in large deformations, manifested as an interaction between interstitial flow and the…
In the present paper, a new three-scale asymptotic homogenization method is proposed to study the electrical behavior of the cardiac tissue structure with multiple heterogeneities at two different levels. The first level is associated with…
Arterial tissue failures lead to a number of clinical conditions that develop rapidly and unpredictably in vivo. Structural components and their interfacial mechanical strength of arterial tissue play a critical role in the process of…