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Hippocampal place and time cells encode spatial and temporal aspects of experience. Both have the same neural substrate, but have been modeled as having different functions and mechanistic origins, place cells as continuous attractors, and…

Neurons and Cognition · Quantitative Biology 2026-04-02 Qiaorong S. Yu , Zhaoze Wang , Vijay Balasubramanian

Deep reinforcement learning agents are often fragile while humans remain adaptive and flexible to varying scenarios. To bridge this gap, we present EDEN, a biologically inspired navigation framework that integrates learned entorhinal-like…

The entorhinal-hippocampal formation is the mammalian brain's navigation system, encoding both physical and abstract spaces via grid cells. This system is well-studied in neuroscience, and its efficiency and versatility make it attractive…

Neural and Evolutionary Computing · Computer Science 2025-03-12 Sven Krausse , Emre Neftci , Friedrich T. Sommer , Alpha Renner

Behavioral flexibility is learning from previous experiences and planning appropriate actions in a changing or novel environment. Successful behavioral adaptation depends on internal models the brain builds to represent the relational…

Neurons and Cognition · Quantitative Biology 2021-07-01 Linda Q. Yu , Seongmin A. Park , Sarah C. Sweigart , Erie D. Boorman , Matthew R. Nassar

The human brain possesses the extraordinary capability to contextualize the information it receives from our environment. The entorhinal-hippocampal plays a critical role in this function, as it is deeply engaged in memory processing and…

Artificial Intelligence · Computer Science 2023-07-06 Paul Stoewer , Achim Schilling , Andreas Maier , Patrick Krauss

Grid cells in the entorhinal cortex are believed to establish their regular, spatially correlated firing patterns by path integration of the animal's motion. Mechanisms for path integration, e.g. in attractor network models, predict…

Neurons and Cognition · Quantitative Biology 2018-08-07 Eli Pollock , Niral Desai , Xue-Xin Wei , Vijay Balasubramanian

Grid cells enable the brain to model the physical space of the world and navigate effectively via path integration, updating self-position using information from self-movement. Recent proposals suggest that the brain might use similar…

Artificial Intelligence · Computer Science 2021-02-19 Niels Leadholm , Marcus Lewis , Subutai Ahmad

We introduce a novel approach to endowing neural networks with emergent, long-term, large-scale memory. Distinct from strategies that connect neural networks to external memory banks via intricately crafted controllers and hand-designed…

Machine Learning · Computer Science 2020-08-18 Tri Huynh , Michael Maire , Matthew R. Walter

To solve a navigation task based on experiences, we need a mechanism to associate places with objects and to recall them along the course of action. In a reward-oriented task, if the route to a reward location is simulated in mind after…

Neurons and Cognition · Quantitative Biology 2024-10-28 Hiroki Nakagawa , Katsumi Tateno , Kensuke Takada , Takashi Morie

To navigate a space, the brain makes an internal representation of the environment using different cells such as place cells, grid cells, head direction cells, border cells, and speed cells. All these cells, along with sensory inputs,…

Robotics · Computer Science 2026-04-17 Hibatallah Meliani , Khadija Slimani , Samira Khoulji

Memory is inherently entangled with prediction and planning. Flexible behavior in biological and artificial agents depends on the interplay of learning from the past and predicting the future in ever-changing environments. This chapter…

Artificial Intelligence · Computer Science 2024-02-21 Ida Momennejad

Sequential firing of hippocampal place cells is often attributed to sequential sensory drive along a trajectory, and has also been attributed to planning and other cognitive functions. Here, we propose a mechanistic and parsimonious…

Neurons and Cognition · Quantitative Biology 2026-03-03 Xiao-Xiong Lin , Yuk-Hoi Yiu , Christian Leibold

How does the mind organize thoughts? The hippocampal-entorhinal complex is thought to support domain-general representation and processing of structural knowledge of arbitrary state, feature and concept spaces. In particular, it enables the…

Artificial Intelligence · Computer Science 2022-02-24 Paul Stoewer , Christian Schlieker , Achim Schilling , Claus Metzner , Andreas Maier , Patrick Krauss

The brain's spatial orientation system uses different neuron ensembles to aid in environment-based navigation. Two of the ways brains encode spatial information is through head direction cells and grid cells. Brains use head direction cells…

Neural and Evolutionary Computing · Computer Science 2023-09-07 Edward C. Mitchell , Brittany Story , David Boothe , Piotr J. Franaszczuk , Vasileios Maroulas

Modeling and understanding the environment is an essential task for autonomous driving. In addition to the detection of objects, in complex traffic scenarios the motion of other road participants is of special interest. Therefore, we…

Robotics · Computer Science 2022-05-06 Marcel Schreiber , Vasileios Belagiannis , Claudius Gläser , Klaus Dietmayer

Recent experimental observations have shown that the reactivation of hippocampal place cells (PC) during sleep or immobility depicts trajectories that can go around barriers and can flexibly adapt to a changing maze layout. Such…

Neurons and Cognition · Quantitative Biology 2022-09-20 Yuanxiang Gao

High-dimensional neural activity often reside in a low-dimensional subspace, referred to as neural manifolds. Grid cells in the medial entorhinal cortex provide a periodic spatial code that are organized near a toroidal manifold,…

Neurons and Cognition · Quantitative Biology 2025-10-22 Yuxing Jared Yao , Iris H. R. Yoon

Grid cells in the entorhinal cortex of mammalian brains exhibit striking hexagon grid firing patterns in their response maps as the animal (e.g., a rat) navigates in a 2D open environment. In this paper, we study the emergence of the…

Neurons and Cognition · Quantitative Biology 2024-02-21 Dehong Xu , Ruiqi Gao , Wen-Hao Zhang , Xue-Xin Wei , Ying Nian Wu

About a decade ago grid cells were discovered in the medial entorhinal cortex of rat. Their peculiar firing patterns, which correlate with periodic locations in the environment, led to early hypothesis that grid cells may provide some form…

Neurons and Cognition · Quantitative Biology 2018-10-18 Jochen Kerdels , Gabriele Peters

Grid cells are believed to play an important role in both spatial and non-spatial cognition tasks. A recent study observed the emergence of grid cells in an LSTM for path integration. The connection between biological and artificial neural…

Neurons and Cognition · Quantitative Biology 2020-09-10 Li Songlin , Deng Yangdong , Wang Zhihua