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The central challenge of AI for Science is not reasoning alone, but the ability to create computational methods in an open-ended scientific world. Existing LLM-based agents rely on static, pre-defined tool libraries, a paradigm that…

Artificial Intelligence · Computer Science 2026-01-13 Jiaxuan Lu , Ziyu Kong , Yemin Wang , Rong Fu , Haiyuan Wan , Cheng Yang , Wenjie Lou , Haoran Sun , Lilong Wang , Yankai Jiang , Xiaosong Wang , Xiao Sun , Dongzhan Zhou

AI agents deployed as persistent assistants must maintain correct beliefs as their information environment evolves. In practice, evidence is scattered across heterogeneous sources that often contradict one another, new information can…

Machine Learning · Computer Science 2026-05-19 Haonian Ji , Kaiwen Xiong , Siwei Han , Peng Xia , Shi Qiu , Yiyang Zhou , Jiaqi Liu , Jinlong Li , Bingzhou Li , Zeyu Zheng , Cihang Xie , Huaxiu Yao

Understanding the intricate interplay among sequence, structure, and function remains a fundamental challenge in proteomics. The sequence-structure-function paradigm posits that biological roles are governed by the tertiary geometric…

Biomolecules · Quantitative Biology 2026-05-14 Hongwang Xiao , Wenjun Lin , Xi Chen , Hui Wang , Kai Chen , Jiashan Li , Yuancheng Sun , Sicheng Dai , Boya Wu , Qiwei Ye

This paper presents an innovative large language model (LLM) agent framework for enhancing diagnostic accuracy in simulated clinical environments using the AgentClinic benchmark. The proposed automatic correction enables doctor agents to…

Artificial Intelligence · Computer Science 2024-10-15 Abhishek Dutta , Yen-Che Hsiao

Artificial intelligence has shown promise in medical imaging, yet most existing systems lack flexibility, interpretability, and adaptability - challenges especially pronounced in ophthalmology, where diverse imaging modalities are…

Current LLM-based agents demonstrate strong performance in episodic task execution but remain constrained by static toolsets and episodic amnesia, failing to accumulate experience across task boundaries. This paper formalizes the…

Artificial Intelligence · Computer Science 2026-05-26 Sihang Jiang , Lipeng Ma , Zhonghua Hong , Keyi Wang , Zhiyu Lu , Tengfei Wang , Shisong Chen , Jinghao Zhang , Tianjun Pan , Weijia Li , Jiaqing Liang , Yanghua Xiao

Recent advancements in Large Language Models (LLMs) have spurred interest in deploying LLM agents to undertake tasks in the world. LLMs are often deployed in agent systems: code that orchestrates LLM calls and provides them with tools. We…

Artificial Intelligence · Computer Science 2025-05-20 Maxime Robeyns , Martin Szummer , Laurence Aitchison

The current paper presents the development and validation of SelfScore, a novel benchmark designed to assess the performance of automated Large Language Model (LLM) agents on help desk and professional consultation tasks. Given the…

Computers and Society · Computer Science 2024-10-23 John Mavi , Nathan Summers , Sergio Coronado

Agents based on Large Language Models (LLMs) are increasingly permeating various domains of human production and life, highlighting the importance of aligning them with human values. The current alignment of AI systems primarily focuses on…

Computation and Language · Computer Science 2024-02-21 Shimin Li , Tianxiang Sun , Qinyuan Cheng , Xipeng Qiu

AI agents are an exciting new research direction, and agent development is driven by benchmarks. Our analysis of current agent benchmarks and evaluation practices reveals several shortcomings that hinder their usefulness in real-world…

Machine Learning · Computer Science 2024-07-02 Sayash Kapoor , Benedikt Stroebl , Zachary S. Siegel , Nitya Nadgir , Arvind Narayanan

Answering complex natural language questions often necessitates multi-step reasoning and integrating external information. Several systems have combined knowledge retrieval with a large language model (LLM) to answer such questions. These…

Personalized AI agents are becoming central to modern information retrieval, yet most evaluation methodologies remain static, relying on fixed benchmarks and one-off metrics that fail to reflect how users' needs evolve over time. These…

Information Retrieval · Computer Science 2025-10-07 Kirandeep Kaur , Preetam Prabhu Srikar Dammu , Hideo Joho , Chirag Shah

AI compliance is becoming increasingly critical as AI systems grow more powerful and pervasive. Yet the rapid expansion of AI policies creates substantial burdens for resource-constrained practitioners lacking policy expertise. Existing…

Human-Computer Interaction · Computer Science 2026-03-26 Yu Yang , Ig-Jae Kim , Dongwook Yoon

Answering complex medical questions requires not only domain expertise and patient-specific information, but also structured and multi-perspective reasoning. Existing multi-agent approaches often rely on fixed roles or shallow interaction…

Artificial Intelligence · Computer Science 2026-03-04 Siqi Ma , Jiajie Huang , Fan Zhang , Yue Shen , Jinlin Wu , Guohui Fan , Zhu Zhang , Zelin Zang

Recent advances in artificial intelligence (AI) agents are pushing AI beyond tools toward autonomous scientific discovery. We discuss two complementary agentic systems for cosmology: \texttt{CMBEvolve}, which targets tasks with explicit…

Instrumentation and Methods for Astrophysics · Physics 2026-05-15 Licong Xu , Thomas Borrett

Background: The surge in single-cell omics data exposes limitations in traditional, manually defined analysis workflows. AI agents offer a paradigm shift, enabling adaptive planning, executable code generation, traceable decisions, and…

Genomics · Quantitative Biology 2026-03-17 Yang Liu , Lu Zhou , Xiawei Du , Ruikun He , Xuguang Zhang , Rongbo Shen , Yixue Li

We envision "AI scientists" as systems capable of skeptical learning and reasoning that empower biomedical research through collaborative agents that integrate AI models and biomedical tools with experimental platforms. Rather than taking…

Intelligent personal assistants (IPAs) such as Siri and Google Assistant are designed to enhance human capabilities and perform tasks on behalf of users. The emergence of LLM agents brings new opportunities for the development of IPAs.…

Artificial Intelligence · Computer Science 2025-08-07 Chongyu Bao , Ruimin Dai , Yangbo Shen , Runyang Jian , Jinghan Zhang , Xiaolan Liu , Kunpeng Liu

Creating agents that can interact naturally with humans is a common goal in artificial intelligence (AI) research. However, evaluating these interactions is challenging: collecting online human-agent interactions is slow and expensive, yet…

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