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Living cells display a remarkable capacity to compartmentalize their functional biochemistry. A particularly fascinating example is the cell nucleus. Exchange of macromolecules between the nucleus and the surrounding cytoplasm does not…

Subcellular Processes · Quantitative Biology 2017-04-19 Ching-Hao Wang , Pankaj Mehta , Michael Elbaum

A distributed computing system is a collection of processors that communicate either by reading and writing from a shared memory or by sending messages over some communication network. Most prior biologically inspired distributed computing…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-05-15 Sabrina Rashid , Gadi Taubenfeld , Ziv Bar-Joseph

Constraint problems can be trivially solved in parallel by exploring different branches of the search tree concurrently. Previous approaches have focused on implementing this functionality in the solver, more or less transparently to the…

Artificial Intelligence · Computer Science 2010-08-26 Lars Kotthoff , Neil C. A. Moore

Mixed packing and covering problems are problems that can be formulated as linear programs using only non-negative coefficients. Examples include multicommodity network flow, the Held-Karp lower bound on TSP, fractional relaxations of set…

Data Structures and Algorithms · Computer Science 2016-01-19 Neal E. Young

We have developed a new programming framework, called Sieve, to support parallel numerical PDE algorithms operating over distributed meshes. We have also developed a reference implementation of Sieve in C++ as a library of generic…

Computational Engineering, Finance, and Science · Computer Science 2010-09-02 Matthew G. Knepley , Dmitry A. Karpeev

Whether P systems with only one catalyst can already be computationally complete, is still an open problem. Here we establish computational completeness by using specific variants of additional control mechanisms. At each step using only…

Formal Languages and Automata Theory · Computer Science 2013-09-06 Rudolf Freund , Gheorghe Păun

This paper introduces and studies a new model of computation called an Alternating Automatic Register Machine (AARM). An AARM possesses the basic features of a conventional register machine and an alternating Turing machine, but can carry…

Computational Complexity · Computer Science 2022-08-18 Ziyuan Gao , Sanjay Jain , Zeyong Li , Ammar Fathin Sabili , Frank Stephan

Building on our recent work on {\em neuromimetic control theory}, new results on resilience and neuro-inspired quantization are reported. The term neuromimetic refers to the models having features that are characteristic of the neurobiology…

Systems and Control · Electrical Eng. & Systems 2022-05-11 Zexin Sun , John Baillieul

We investigate sparse matrix bipartitioning -- a problem where we minimize the communication volume in parallel sparse matrix-vector multiplication. We prove, by reduction from graph bisection, that this problem is $\mathcal{NP}$-complete…

Data Structures and Algorithms · Computer Science 2020-05-08 Timon E. Knigge , Rob H. Bisseling

A novel theory for cell differentiation is proposed, based on simulations with interacting artificial cells which have metabolic networks within, and divide into two when the final product is accumulated. Results of simulations with coupled…

adap-org · Physics 2015-06-30 Kunihiko Kaneko , Tetsuya Yomo

Particle tracking has several important applications for solute transport studies in aquifer systems. Travel time distribution at observation points, particle coordinates in time and streamlines are some practical results providing…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-02-28 Rodrigo Pérez-Illanes , Daniel Fernàndez-Garcia

NP complete problem is one of the most challenging issues. The question of whether all problems in NP are also in P is generally considered one of the most important open questions in mathematics and theoretical computer science as it has…

Computational Complexity · Computer Science 2015-05-04 Wenhong Tian , GuoZhong Li , Xinyang Wang , Qin Xiong , Yaqiu Jiang

A neuromorphic metasurface embodies mechanical intelligence by realizing physical neural architectures. It exploits guided wave scattering to conduct computations in an analog manner. Through multiple tuned waveguides, the neuromorphic…

Applied Physics · Physics 2025-10-22 M. Mousa , M. Moghaddaszadeh , M. Nouh

In the mammalian nervous system, various synaptic plasticity rules act, either individually or synergistically, and over wide-ranging timescales to dictate the processes that enable learning and memory formation. To mimic biological…

Disordered Systems and Neural Networks · Physics 2021-06-11 Syed Ghazi Sarwat , Benedikt Kersting , Timoleon Moraitis , Vara Prasad Jonnalagadda , Abu Sebastian

With the rapid advent of biomedical and biotechnological innovations, a deep understanding of the nature of interaction between nanomaterials and cell membranes, tissues, and organs, has become increasingly important. Active penetration of…

Soft Condensed Matter · Physics 2019-09-26 Abdallah Daddi-Moussa-Ider , Benno Liebchen , Andreas M. Menzel , Hartmut Löwen

Kernelization is the standard framework to analyze preprocessing routines mathematically. Here, in terms of efficiency, we demand the preprocessing routine to run in time polynomial in the input size. However, today, various NP-complete…

Computational Complexity · Computer Science 2025-08-15 Hendrik Molter , Meirav Zehavi

Machine learning components commonly appear in larger decision-making pipelines; however, the model training process typically focuses only on a loss that measures accuracy between predicted values and ground truth values. Decision-focused…

Machine Learning · Computer Science 2019-07-19 Aaron Ferber , Bryan Wilder , Bistra Dilkina , Milind Tambe

Phase-change memory (PCM) devices have multiple banks to serve memory requests in parallel. Unfortunately, if two requests go to the same bank, they have to be served one after another, leading to lower system performance. We observe that a…

Hardware Architecture · Computer Science 2019-08-22 Shihao Song , Anup Das , Onur Mutlu , Nagarajan Kandasamy

Considering the issue of estimating small probabilities p, ie. measuring a rare domain F = {x | g(x) > q} with respect to the distribution of a random vector X, Multilevel Splitting strategies (also called Subset Simulation) aim at writing…

Computation · Statistics 2015-09-10 Clément Walter

We present a field theory to describe the composition of a surface spontaneously exchanging matter with its bulk environment. By only assuming matter conservation in the system, we show with extensive numerical simulations that, depending…

Biological Physics · Physics 2023-08-09 Nirvana Caballero , Karsten Kruse , Thierry Giamarchi