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The ocean is filled with microscopic microalgae called phytoplankton, which together are responsible for as much photosynthesis as all plants on land combined. Our ability to predict their response to the warming ocean relies on…

Applications · Statistics 2022-08-05 Sangwon Hyun , Mattias Rolf Cape , Francois Ribalet , Jacob Bien

Ocean microbes are critical to both ocean ecosystems and the global climate. Flow cytometry, which measures cell optical properties in fluid samples, is routinely used in oceanographic research. Despite decades of accumulated data,…

Methodology · Statistics 2025-04-17 Sangwon Hyun , Tim Coleman , Francois Ribalet , Jacob Bien

The ocean is filled with phytoplankton that contribute as much photosynthesis as all land plants combined, making them vital to the carbon cycle and climate system. Recent advances in flow cytometry allow oceanographers to measure the…

Methodology · Statistics 2026-03-09 Yik Lun Kei , Qi Wang , Paul Parker , Francois Ribalet , Sangwon Hyun

Flow cytometry mainly used for detecting the characteristics of a number of biochemical substances based on the expression of specific markers in cells. It is particularly useful for detecting membrane surface receptors, antigens, ions, or…

Machine Learning · Computer Science 2023-03-17 Yanhua Xu

Flow cytometry is a technology that rapidly measures antigen-based markers associated to cells in a cell population. Although analysis of flow cytometry data has traditionally considered one or two markers at a time, there has been…

Applications · Statistics 2010-03-30 Gyemin Lee , William Finn , Clayton Scott

Marine chlorophyll which is present within phytoplankton are the basis of photosynthesis and they have a high significance in sustaining ecological balance as they highly contribute toward global primary productivity and comes under the…

Quantitative Methods · Quantitative Biology 2023-04-26 Subhrangshu Adhikary , Sudhir Kumar Chaturvedi , Saikat Banerjee , Sourav Basu

Phytoplankton are microscopic algae responsible for roughly half of the world's photosynthesis that play a critical role in global carbon cycles and oxygen production, and measuring the abundance of their subtypes across a wide range of…

Methodology · Statistics 2025-10-08 Farhad de Sousa , François Ribalet , Jacob Bien

Imaging flow cytometry systems aim to analyze a huge number of cells or micro-particles based on their physical characteristics. The vast majority of current systems acquire a large amount of images which are used to train deep artificial…

Neural and Evolutionary Computing · Computer Science 2023-03-21 Muhammed Gouda , Steven Abreu , Alessio Lugnan , Peter Bienstman

Flow cytometry is a widespread single-cell measurement technology with a multitude of clinical and research applications. Interpretation of flow cytometry data is hard; the instrumentation is delicate and can not render absolute…

Applications · Statistics 2015-02-16 Jonas Wallin , Kerstin Johnsson , Magnus Fontes

Flow cytometry (FCM) is the standard multi-parameter assay for measuring single cell phenotype and functionality. It is commonly used for quantifying the relative frequencies of cell subsets in blood and disaggregated tissues. A typical…

Applications · Statistics 2020-09-01 Shai Gorsky , Cliburn Chan , Li Ma

Flow cytometry (FC) is a single-cell profiling platform for measuring the phenotypes of individual cells from millions of cells in biological samples. FC employs high-throughput technologies and generates high-dimensional data, and hence…

Quantitative Methods · Quantitative Biology 2015-01-16 Ariful Azad

Flow cytometry is a technique that measures multiple fluorescence and light scatter-associated parameters from individual cells as they flow a single file through an excitation light source. These cells are labeled with antibodies to detect…

Generating high-quality time-series data is challenging because real-world signals often exhibit multimodal patterns and multiscale dynamics, including oscillations and high-frequency variations. Flow Matching (FM) offers an efficient…

Machine Learning · Computer Science 2026-05-29 Junru Zhang , Lang Feng , Jinbo Wang , Xu Guo , Yucheng Wang , Han Yu , Min Wu , Yabo Dong , Duanqing Xu

Many biological systems evolve through continuous local dynamics while switching between latent regimes defined by learning, stimulus context, internal state, or developmental stage. These processes are often observed only as unpaired…

Machine Learning · Computer Science 2026-05-12 Josue Ortega Caro , Yongxu Zhang , Hannah M Batchelor , Sizhuang He , Jessica Cardin , Shreya Saxena

A mixture of experts models the conditional density of a response variable using a mixture of regression models with covariate-dependent mixture weights. We extend the finite mixture of experts model by allowing the parameters in both the…

Computation · Statistics 2022-10-14 Parfait Munezero , Mattias Villani , Robert Kohn

Simulating abundances of stable water isotopologues, i.e. molecules differing in their isotopic composition, within climate models allows for comparisons with proxy data and, thus, for testing hypotheses about past climate and validating…

Atmospheric and Oceanic Physics · Physics 2023-11-28 Jonathan Wider , Jakob Kruse , Nils Weitzel , Janica C. Bühler , Ullrich Köthe , Kira Rehfeld

Phytoplankton is the basis of marine food webs, driving both ecological processes and global biogeochemical cycles. Despite their ecological and climatic significance, accurately simulating phytoplankton dynamics remains a major challenge…

Machine Learning · Computer Science 2026-02-05 Mahima Lakra , Ronan Fablet , Lucas Drumetz , Etienne Pauthenet , Elodie Martinez

Flow cytometry is a powerful quantitative assay supporting high-throughput collection of single-cell data with a high dynamic range. For flow cytometry to yield reproducible data with a quantitative relationship to the underlying biology,…

Quantitative Methods · Quantitative Biology 2023-05-16 Jacob Beal

Flow cytometry measurements are widely used in diagnostics and medical decision making. Incomplete understanding of sources of measurement uncertainty can make it difficult to distinguish autofluorescence and background sources from signals…

Quantitative Methods · Quantitative Biology 2024-12-02 Prajakta Bedekar , Megan A. Catterton , Matthew DiSalvo , Gregory A. Cooksey , Anthony J. Kearsley , Paul N. Patrone

We present an experimental imaging flow cytometer using a 1 {\mu}s temporal resolution event-based CMOS camera, with data processed by adaptive feedforward and recurrent spiking neural networks. Our study classifies PMMA particles (12, 16,…

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