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Multiplexed imaging data are revolutionizing our understanding of the composition and organization of tissues and tumors. A critical aspect of such tissue profiling is quantifying the spatial relationship relationships among cells at…

Quantitative Methods · Quantitative Biology 2024-05-06 Ajit J. Nirmal , Peter K. Sorger

Feature pyramids have been widely adopted in convolutional neural networks and transformers for tasks in medical image segmentation. However, existing models generally focus on the Encoder-side Transformer for feature extraction. We further…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Hongyi Cai , Mohammad Mahdinur Rahman , Wenzhen Dong , Jingyu Wu

Image-based or morphological profiling is a rapidly expanding field wherein cells are "profiled" by extracting hundreds to thousands of unbiased, quantitative features from images of cells that have been perturbed by genetic or chemical…

Quantitative Methods · Quantitative Biology 2024-11-07 Erin Weisbart , Ankur Kumar , John Arevalo , Anne E. Carpenter , Beth A. Cimini , Shantanu Singh

Modern single-cell flow and mass cytometry technologies measure the expression of several proteins of the individual cells within a blood or tissue sample. Each profiled biological sample is thus represented by a set of hundreds of…

Machine Learning · Computer Science 2022-06-29 Siyuan Shan , Vishal Baskaran , Haidong Yi , Jolene Ranek , Natalie Stanley , Junier Oliva

Image registration is a key component of various image processing operations which involve the analysis of different image data sets. Automatic image registration domains have witnessed the application of many intelligent methodologies over…

Computer Vision and Pattern Recognition · Computer Science 2014-05-26 P. V. Arun , S. K. Katiyar

Live-cell imaging (LCI) technology enables the detailed spatio-temporal characterization of living cells at the single-cell level, which is critical for advancing research in the life sciences, from biomedical applications to bioprocessing.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Johannes Seiffarth , Keitaro Kasahara , Michelle Bund , Benita Lückel , Richard D. Paul , Matthias Pesch , Lennart Witting , Michael Bott , Dietrich Kohlheyer , Katharina Nöh

De-identification of medical images is a critical step to ensure privacy during data sharing in research and clinical settings. The initial step in this process involves detecting Protected Health Information (PHI), which can be found in…

Computer Vision and Pattern Recognition · Computer Science 2025-06-26 Tuan Truong , Ivo M. Baltruschat , Mark Klemens , Grit Werner , Matthias Lenga

Recent breakthroughs in self-supervised learning have enabled the use of large unlabeled datasets to train visual foundation models that can generalize to a variety of downstream tasks. While this training paradigm is well suited for the…

As a fundamental visual attribute, image complexity significantly influences both human perception and the performance of computer vision models. However, accurately assessing and quantifying image complexity remains a challenging task. (1)…

Computer Vision and Pattern Recognition · Computer Science 2025-04-28 Shipeng Liu , Liang Zhao , Dengfeng Chen

Recently, the computer vision and machine learning community has been in favor of feature extraction pipelines that rely on a coding step followed by a linear classifier, due to their overall simplicity, well understood properties of linear…

Machine Learning · Computer Science 2013-04-17 Oriol Vinyals , Yangqing Jia , Trevor Darrell

Feature extraction is a critical component of many applied data science workflows. In recent years, rapid advances in artificial intelligence and machine learning have led to an explosion of feature extraction tools and services that allow…

Computer Vision and Pattern Recognition · Computer Science 2017-02-22 Quinten McNamara , Alejandro de la Vega , Tal Yarkoni

Bright-field microscopy, a cost-effective solution for live-cell culture, is often the only resource available, along with standard CPUs, for many low-budget labs. The inherent challenges of bright-field images -- their noisiness, low…

Quantitative Methods · Quantitative Biology 2025-11-03 Surajit Das , Pavel Zun

Iterative prompt refinement is central to reproducing target images with text to image generative models. Previous studies have incorporated image similarity metrics (ISMs) as additional feedback to human users. Existing ISMs such as LPIPS…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Khoi Trinh , Jay Rothenberger , Scott Seidenberger , Dimitrios Diochnos , Anindya Maiti

Nowadays, the amount of heterogeneous biomedical data is increasing more and more thanks to novel sensing techniques and high-throughput technologies. In reference to biomedical image analysis, the advances in image acquisition modalities…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Leonardo Rundo

We propose a novel Coupled Projection multi-task Metric Learning (CP-mtML) method for large scale face retrieval. In contrast to previous works which were limited to low dimensional features and small datasets, the proposed method scales to…

Computer Vision and Pattern Recognition · Computer Science 2016-04-12 Binod Bhattarai , Gaurav Sharma , Frederic Jurie

Liquid chromatography with tandem mass spectrometry (LC-MS/MS) based proteomics is a well-established research field with major applications such as identification of disease biomarkers, drug discovery, drug design and development. In…

Quantitative Methods · Quantitative Biology 2018-01-08 Fatema Tuz Zohora , Ngoc Hieu Tran , Xianglilan Zhang , Lei Xin , Baozhen Shan , Ming Li

Background and Objective: Deep learning enables tremendous progress in medical image analysis. One driving force of this progress are open-source frameworks like TensorFlow and PyTorch. However, these frameworks rarely address issues…

Image and Video Processing · Electrical Eng. & Systems 2021-04-29 Alain Jungo , Olivier Scheidegger , Mauricio Reyes , Fabian Balsiger

Radiomics enables the extraction of quantitative biomarkers from medical images for precision modeling, but reproducibility and scalability remain limited due to heterogeneous software implementations and incomplete adherence to standards.…

Diffusion models have a tendency to exactly replicate their training data, especially when trained on small datasets. Most prior work has sought to mitigate this problem by imposing differential privacy constraints or masking parts of the…

Machine Learning · Computer Science 2024-09-12 Joshua Kazdan , Hao Sun , Jiaqi Han , Felix Petersen , Stefano Ermon

Feature extraction and matching are among central problems of computer vision. It is inefficent to search features over all locations and scales. Neurophysiological evidence shows that to locate objects in a digital image the human visual…

Computer Vision and Pattern Recognition · Computer Science 2007-05-23 Liang Wu