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Medicine is inherently multimodal, with rich data modalities spanning text, imaging, genomics, and more. Generalist biomedical artificial intelligence (AI) systems that flexibly encode, integrate, and interpret this data at scale can…

Advancements in high-throughput technologies have led to a shift from traditional hypothesis-driven methodologies to data-driven approaches. Multi-omics refers to the integrative analysis of data derived from multiple 'omes', such as…

Genomics · Quantitative Biology 2024-10-17 Ahmad Hussein , Mukesh Prasad , Ali Braytee

The increasing demand for transparent and reliable models, particularly in high-stakes decision-making areas such as medical image analysis, has led to the emergence of eXplainable Artificial Intelligence (XAI). Post-hoc XAI techniques,…

Computer Vision and Pattern Recognition · Computer Science 2024-11-18 Junlin Hou , Sicen Liu , Yequan Bie , Hongmei Wang , Andong Tan , Luyang Luo , Hao Chen

The escalating integration of machine learning in high-stakes fields such as healthcare raises substantial concerns about model fairness. We propose an interpretable framework - Fairness-Aware Interpretable Modeling (FAIM), to improve model…

Machine Learning · Computer Science 2024-03-11 Mingxuan Liu , Yilin Ning , Yuhe Ke , Yuqing Shang , Bibhas Chakraborty , Marcus Eng Hock Ong , Roger Vaughan , Nan Liu

The recent boom of large language models (LLMs) has re-ignited the hope that artificial intelligence (AI) systems could aid medical diagnosis. Yet despite dazzling benchmark scores, LLM assistants have yet to deliver measurable improvements…

Artificial Intelligence · Computer Science 2025-07-03 Matthew JY Kang , Wenli Yang , Monica R Roberts , Byeong Ho Kang , Charles B Malpas

Artificial intelligence (AI) provides considerable opportunities to assist human work. However, one crucial challenge of human-AI collaboration is that many AI algorithms operate in a black-box manner where the way how the AI makes…

Human-Computer Interaction · Computer Science 2024-06-13 Julian Senoner , Simon Schallmoser , Bernhard Kratzwald , Stefan Feuerriegel , Torbjørn Netland

Generalist Medical AI (GMAI) systems have demonstrated expert-level performance in biomedical perception tasks, yet their clinical utility remains limited by inadequate multi-modal explainability and suboptimal prognostic capabilities.…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Honglong Yang , Shanshan Song , Yi Qin , Lehan Wang , Haonan Wang , Xinpeng Ding , Qixiang Zhang , Bodong Du , Xiaomeng Li

Explainable artificial intelligence (XAI) is an emerging new domain in which a set of processes and tools allow humans to better comprehend the decisions generated by black box models. However, most of the available XAI tools are often…

Machine Learning · Computer Science 2021-07-22 Zoumpolia Dikopoulou , Serafeim Moustakidis , Patrik Karlsson

The use of deep learning in computer vision tasks such as image classification has led to a rapid increase in the performance of such systems. Due to this substantial increment in the utility of these systems, the use of artificial…

Image and Video Processing · Electrical Eng. & Systems 2023-04-05 Vinay Jogani , Joy Purohit , Ishaan Shivhare , Seema C Shrawne

The use of wearables in medicine and wellness, enabled by AI-based models, offers tremendous potential for real-time monitoring and interpretable event detection. Explainable AI (XAI) is required to assess what models have learned and build…

Signal Processing · Electrical Eng. & Systems 2026-03-16 Maurice Kuschel , Solveig Vieluf , Claus Reinsberger , Tobias Loddenkemper , Tanuj Hasija

Explainable artificial intelligence (XAI) is essential for enabling clinical users to get informed decision support from AI and comply with evidence-based medical practice. Applying XAI in clinical settings requires proper evaluation…

Machine Learning · Computer Science 2022-12-09 Weina Jin , Xiaoxiao Li , Mostafa Fatehi , Ghassan Hamarneh

Artificial intelligence has become pervasive across disciplines and fields, and biomedical image and signal processing is no exception. The growing and widespread interest on the topic has triggered a vast research activity that is…

Machine Learning · Computer Science 2022-07-12 Guang Yang , Arvind Rao , Christine Fernandez-Maloigne , Vince Calhoun , Gloria Menegaz

Developing safe, effective, and practically useful clinical prediction models (CPMs) traditionally requires iterative collaboration between clinical experts, data scientists, and informaticists. This process refines the often small but…

Artificial Intelligence · Computer Science 2026-01-15 Jean Feng , Avni Kothari , Patrick Vossler , Andrew Bishara , Lucas Zier , Newton Addo , Aaron Kornblith , Yan Shuo Tan , Chandan Singh

Recent advancements in artificial intelligence (AI) have facilitated its widespread adoption in primary medical services, addressing the demand-supply imbalance in healthcare. Vision Transformers (ViT) have emerged as state-of-the-art…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Tin Lai

In recent years, AI systems in the medical domain have advanced significantly. However, despite outperforming humans, they are rarely used in practice since it is often not clear how they make their decisions. Optimal explanation and…

Human-Computer Interaction · Computer Science 2026-05-06 Julia Wagner , Tim Schlippe

Nowadays Artificial Intelligence (AI) has become a fundamental component of healthcare applications, both clinical and remote, but the best performing AI systems are often too complex to be self-explaining. Explainable AI (XAI) techniques…

Machine Learning · Computer Science 2022-09-15 Flavio Di Martino , Franca Delmastro

The adoption of intelligent systems creates opportunities as well as challenges for medical work. On the positive side, intelligent systems have the potential to compute complex data from patients and generate automated diagnosis…

Human-Computer Interaction · Computer Science 2019-02-19 Yao Xie , Ge Gao , Xiang 'Anthony' Chen

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

The recent development of data-driven AI promises to automate medical diagnosis; however, most AI functions as 'black boxes' to physicians with limited computational knowledge. Using medical imaging as a point of departure, we conducted…

Human-Computer Interaction · Computer Science 2020-01-22 Yao Xie , Melody Chen , David Kao , Ge Gao , Xiang 'Anthony' Chen